Polymer-based nanosystems and their applications in bone anticancer therapy
The mortality rate of bone cancer has witnessed a substantial reduction in recent years, all thanks to the advent of advanced cancer treatment modalities such as surgical intervention, radiation, and chemotherapy. Nevertheless, these popular modalities come with a set of clinical challenges, includi...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1218511/full |
| _version_ | 1827906485113323520 |
|---|---|
| author | Wanis Nafo |
| author_facet | Wanis Nafo |
| author_sort | Wanis Nafo |
| collection | DOAJ |
| description | The mortality rate of bone cancer has witnessed a substantial reduction in recent years, all thanks to the advent of advanced cancer treatment modalities such as surgical intervention, radiation, and chemotherapy. Nevertheless, these popular modalities come with a set of clinical challenges, including non-specificity, side effects, and drug intolerance. In recent years, polymer-based nanosystems have emerged as a promising solution in bone anti-cancer therapy by virtue of their unique physical and chemical properties. These nanosystems can be tailored for use in different drug release mechanisms for therapeutic implementations. This review delves into the efficacy of these therapy applications in bone cancer (with a focus on one of the most common types of cancers, Osteosarcoma) treatment and their correlation with the properties of polymer-based nanosystems, in addition to their interaction with the tumor microenvironment and the biological milieu. |
| first_indexed | 2024-03-13T00:57:15Z |
| format | Article |
| id | doaj.art-9060dab43a4b460fb2acdeb95f198889 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-13T00:57:15Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-9060dab43a4b460fb2acdeb95f1988892023-07-06T16:30:32ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-07-011110.3389/fchem.2023.12185111218511Polymer-based nanosystems and their applications in bone anticancer therapyWanis NafoThe mortality rate of bone cancer has witnessed a substantial reduction in recent years, all thanks to the advent of advanced cancer treatment modalities such as surgical intervention, radiation, and chemotherapy. Nevertheless, these popular modalities come with a set of clinical challenges, including non-specificity, side effects, and drug intolerance. In recent years, polymer-based nanosystems have emerged as a promising solution in bone anti-cancer therapy by virtue of their unique physical and chemical properties. These nanosystems can be tailored for use in different drug release mechanisms for therapeutic implementations. This review delves into the efficacy of these therapy applications in bone cancer (with a focus on one of the most common types of cancers, Osteosarcoma) treatment and their correlation with the properties of polymer-based nanosystems, in addition to their interaction with the tumor microenvironment and the biological milieu.https://www.frontiersin.org/articles/10.3389/fchem.2023.1218511/fullosteosarcomatargeted drug deliverynanoparticlesinternal stimulationexternal stimulation |
| spellingShingle | Wanis Nafo Polymer-based nanosystems and their applications in bone anticancer therapy Frontiers in Chemistry osteosarcoma targeted drug delivery nanoparticles internal stimulation external stimulation |
| title | Polymer-based nanosystems and their applications in bone anticancer therapy |
| title_full | Polymer-based nanosystems and their applications in bone anticancer therapy |
| title_fullStr | Polymer-based nanosystems and their applications in bone anticancer therapy |
| title_full_unstemmed | Polymer-based nanosystems and their applications in bone anticancer therapy |
| title_short | Polymer-based nanosystems and their applications in bone anticancer therapy |
| title_sort | polymer based nanosystems and their applications in bone anticancer therapy |
| topic | osteosarcoma targeted drug delivery nanoparticles internal stimulation external stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1218511/full |
| work_keys_str_mv | AT wanisnafo polymerbasednanosystemsandtheirapplicationsinboneanticancertherapy |