Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome
The metabolic syndrome is a highly prevalent condition associated with increased cardiovascular risk in the population. Microvasculature is the terminal part of the cardiovascular system which primarily reacts to the increased secretion of the pro inflammatory adipokines typical for the metabolic sy...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2018-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/1730 |
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| author | V. I. Podzolkov T. V. Koroleva M. V. Pisarev M. G. Kudryavtseva D. A. Zateyshchikova |
| author_facet | V. I. Podzolkov T. V. Koroleva M. V. Pisarev M. G. Kudryavtseva D. A. Zateyshchikova |
| author_sort | V. I. Podzolkov |
| collection | DOAJ |
| description | The metabolic syndrome is a highly prevalent condition associated with increased cardiovascular risk in the population. Microvasculature is the terminal part of the cardiovascular system which primarily reacts to the increased secretion of the pro inflammatory adipokines typical for the metabolic syndrome. Microcirculation and blood cell abnormalities are the leading mechanisms of cardiovascular events development in this condition. Prevalence of microcirculation abnormalities and red blood cell dysfunction in metabolic syndrome and their role in the increased blood viscosity and cardiovascular events development are covered by the paper. The microcirculation abnormalities with a special focus on red blood cell dysfunction (impaired aggregation, stiffness) seen in metabolic syndrome and associated conditions are discussed in detail. The impact of abnormal red blood cell deformability (secondary to cholesterol accumulation in the cellular membranes) on the hemorheological abnormalities is revealed. Abnormal red blood cell surface charge due to proinflammatory changes associated with insulin resistance in diabetes mellitus is highlighted. These abnormalities lead to increased red blood cell aggregation and plasma viscosity that are the essential components of cardiovascular events pathogenesis. Their timely diagnosis is crucial for effective cardiovascular prevention. |
| first_indexed | 2024-03-08T14:02:13Z |
| format | Article |
| id | doaj.art-906129188ec04d83ad9deaeb5671625a |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:55:59Z |
| publishDate | 2018-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-906129188ec04d83ad9deaeb5671625a2024-04-01T07:43:37ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532018-09-0114459159710.20996/1819-6446-2018-14-4-591-5971512Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic SyndromeV. I. Podzolkov0T. V. Koroleva1M. V. Pisarev2M. G. Kudryavtseva3D. A. Zateyshchikova4I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)The metabolic syndrome is a highly prevalent condition associated with increased cardiovascular risk in the population. Microvasculature is the terminal part of the cardiovascular system which primarily reacts to the increased secretion of the pro inflammatory adipokines typical for the metabolic syndrome. Microcirculation and blood cell abnormalities are the leading mechanisms of cardiovascular events development in this condition. Prevalence of microcirculation abnormalities and red blood cell dysfunction in metabolic syndrome and their role in the increased blood viscosity and cardiovascular events development are covered by the paper. The microcirculation abnormalities with a special focus on red blood cell dysfunction (impaired aggregation, stiffness) seen in metabolic syndrome and associated conditions are discussed in detail. The impact of abnormal red blood cell deformability (secondary to cholesterol accumulation in the cellular membranes) on the hemorheological abnormalities is revealed. Abnormal red blood cell surface charge due to proinflammatory changes associated with insulin resistance in diabetes mellitus is highlighted. These abnormalities lead to increased red blood cell aggregation and plasma viscosity that are the essential components of cardiovascular events pathogenesis. Their timely diagnosis is crucial for effective cardiovascular prevention.https://www.rpcardio.online/jour/article/view/1730metabolic syndromemicrocirculation abnormalitiesblood viscosityred blood cell surface chargecardiovascular risk |
| spellingShingle | V. I. Podzolkov T. V. Koroleva M. V. Pisarev M. G. Kudryavtseva D. A. Zateyshchikova Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome Рациональная фармакотерапия в кардиологии metabolic syndrome microcirculation abnormalities blood viscosity red blood cell surface charge cardiovascular risk |
| title | Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome |
| title_full | Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome |
| title_fullStr | Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome |
| title_full_unstemmed | Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome |
| title_short | Abnormal Microcirculation and Red Blood Cell Function as a Cardiovascular Risk Factor in Metabolic Syndrome |
| title_sort | abnormal microcirculation and red blood cell function as a cardiovascular risk factor in metabolic syndrome |
| topic | metabolic syndrome microcirculation abnormalities blood viscosity red blood cell surface charge cardiovascular risk |
| url | https://www.rpcardio.online/jour/article/view/1730 |
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