LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases
The prevalence and mortality rates of cardiovascular diseases are increasing, and new treatment strategies are urgently needed. From the perspective of basic pathogenesis, the occurrence and development of cardiovascular diseases are related to inflammation, apoptosis, fibrosis and autophagy of card...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-11-01
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Series: | Frontiers in Pharmacology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1045501/full |
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author | Zining Li Zining Li Zining Li Jialiang Gao Jialiang Gao Jialiang Gao Di Sun Di Sun Di Sun Qian Jiao Qian Jiao Qian Jiao Jing Ma Jing Ma Jing Ma Weilu Cui Weilu Cui Weilu Cui Yuqing Lou Yuqing Lou Yuqing Lou Fan Xu Fan Xu Fan Xu Shanshan Li Shanshan Li Shanshan Li Haixia Li Haixia Li Haixia Li |
author_facet | Zining Li Zining Li Zining Li Jialiang Gao Jialiang Gao Jialiang Gao Di Sun Di Sun Di Sun Qian Jiao Qian Jiao Qian Jiao Jing Ma Jing Ma Jing Ma Weilu Cui Weilu Cui Weilu Cui Yuqing Lou Yuqing Lou Yuqing Lou Fan Xu Fan Xu Fan Xu Shanshan Li Shanshan Li Shanshan Li Haixia Li Haixia Li Haixia Li |
author_sort | Zining Li |
collection | DOAJ |
description | The prevalence and mortality rates of cardiovascular diseases are increasing, and new treatment strategies are urgently needed. From the perspective of basic pathogenesis, the occurrence and development of cardiovascular diseases are related to inflammation, apoptosis, fibrosis and autophagy of cardiomyocytes, endothelial cells and other related cells. The involvement of maternally expressed gene 3 (MEG3) in human disease processes has been increasingly reported. P53 and PI3K/Akt are important pathways by which MEG3 participates in regulating cell apoptosis. MEG3 directly or competitively binds with miRNA to participate in apoptosis, inflammation, oxidative stress, endoplasmic reticulum stress, EMT and other processes. LncRNA MEG3 is mainly involved in malignant tumors, metabolic diseases, immune system diseases, cardiovascular and cerebrovascular diseases, etc., LncRNA MEG3 has a variety of pathological effects in cardiomyocytes, fibroblasts and endothelial cells and has great clinical application potential in the prevention and treatment of AS, MIRI, hypertension and HF. This paper will review the research progress of MEG3 in the aspects of mechanism of action, other systemic diseases and cardiovascular diseases, and point out its great potential in the prevention and treatment of cardiovascular diseases. lncRNAs also play a role in endothelial cells. In addition, lncRNA MEG3 has shown biomarker value, prognostic value and therapeutic response measurement in tumor diseases. We boldly speculate that MEG3 will play a role in the emerging discipline of tumor heart disease. |
first_indexed | 2024-04-11T15:06:15Z |
format | Article |
id | doaj.art-90616091efb348a0bcf5dc13f6bfc5e9 |
institution | Directory Open Access Journal |
issn | 1663-9812 |
language | English |
last_indexed | 2024-04-11T15:06:15Z |
publishDate | 2022-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Pharmacology |
spelling | doaj.art-90616091efb348a0bcf5dc13f6bfc5e92022-12-22T04:16:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10455011045501LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseasesZining Li0Zining Li1Zining Li2Jialiang Gao3Jialiang Gao4Jialiang Gao5Di Sun6Di Sun7Di Sun8Qian Jiao9Qian Jiao10Qian Jiao11Jing Ma12Jing Ma13Jing Ma14Weilu Cui15Weilu Cui16Weilu Cui17Yuqing Lou18Yuqing Lou19Yuqing Lou20Fan Xu21Fan Xu22Fan Xu23Shanshan Li24Shanshan Li25Shanshan Li26Haixia Li27Haixia Li28Haixia Li29Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Division, Beijing, ChinaDeputy Chief Physician, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMaster’s Degree Student, Beijing, ChinaCardiovascular Division, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Division, Beijing, ChinaChief Physician, Beijing, ChinaThe prevalence and mortality rates of cardiovascular diseases are increasing, and new treatment strategies are urgently needed. From the perspective of basic pathogenesis, the occurrence and development of cardiovascular diseases are related to inflammation, apoptosis, fibrosis and autophagy of cardiomyocytes, endothelial cells and other related cells. The involvement of maternally expressed gene 3 (MEG3) in human disease processes has been increasingly reported. P53 and PI3K/Akt are important pathways by which MEG3 participates in regulating cell apoptosis. MEG3 directly or competitively binds with miRNA to participate in apoptosis, inflammation, oxidative stress, endoplasmic reticulum stress, EMT and other processes. LncRNA MEG3 is mainly involved in malignant tumors, metabolic diseases, immune system diseases, cardiovascular and cerebrovascular diseases, etc., LncRNA MEG3 has a variety of pathological effects in cardiomyocytes, fibroblasts and endothelial cells and has great clinical application potential in the prevention and treatment of AS, MIRI, hypertension and HF. This paper will review the research progress of MEG3 in the aspects of mechanism of action, other systemic diseases and cardiovascular diseases, and point out its great potential in the prevention and treatment of cardiovascular diseases. lncRNAs also play a role in endothelial cells. In addition, lncRNA MEG3 has shown biomarker value, prognostic value and therapeutic response measurement in tumor diseases. We boldly speculate that MEG3 will play a role in the emerging discipline of tumor heart disease.https://www.frontiersin.org/articles/10.3389/fphar.2022.1045501/fulllncRNA MEG3cardiovascular diseasesP53 signaling pathwayPI3K/akt signaling pathwayapoptosisautophagy |
spellingShingle | Zining Li Zining Li Zining Li Jialiang Gao Jialiang Gao Jialiang Gao Di Sun Di Sun Di Sun Qian Jiao Qian Jiao Qian Jiao Jing Ma Jing Ma Jing Ma Weilu Cui Weilu Cui Weilu Cui Yuqing Lou Yuqing Lou Yuqing Lou Fan Xu Fan Xu Fan Xu Shanshan Li Shanshan Li Shanshan Li Haixia Li Haixia Li Haixia Li LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases Frontiers in Pharmacology lncRNA MEG3 cardiovascular diseases P53 signaling pathway PI3K/akt signaling pathway apoptosis autophagy |
title | LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases |
title_full | LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases |
title_fullStr | LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases |
title_full_unstemmed | LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases |
title_short | LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases |
title_sort | lncrna meg3 potential stock for precision treatment of cardiovascular diseases |
topic | lncRNA MEG3 cardiovascular diseases P53 signaling pathway PI3K/akt signaling pathway apoptosis autophagy |
url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1045501/full |
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