A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense e...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-05-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2018.00166/full |
| _version_ | 1818155162141720576 |
|---|---|
| author | VijayKumar Patra VijayKumar Patra VijayKumar Patra Léo Laoubi Jean-François Nicolas Jean-François Nicolas Marc Vocanson Peter Wolf |
| author_facet | VijayKumar Patra VijayKumar Patra VijayKumar Patra Léo Laoubi Jean-François Nicolas Jean-François Nicolas Marc Vocanson Peter Wolf |
| author_sort | VijayKumar Patra |
| collection | DOAJ |
| description | The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). UV-R can promote or inhibit the growth of microbes on the skin and modulate the immune system which can be either favorable or harmful. Among potential UV-R targets, skin resident memory T cells (TRM) stand as well positioned immune cells at the forefront within the skin. Both CD4+ or CD8+ αβ TRM cells residing permanently in peripheral tissues have been shown to play prominent roles in providing accelerated and long-lived specific immunity, tissue homeostasis, wound repair. Nevertheless, their response upon UV-R exposure or signals from microbiome are poorly understood compared to resident TCRγδ cells. Skin TRM survive for long periods of time and are exposed to innumerable antigens during lifetime. The interplay of TRM with skin residing microbes may be crucial in pathophysiology of various diseases including psoriasis, atopic dermatitis and polymorphic light eruption. In this article, we share our perspective about how UV-R may directly shape the persistence, phenotype, specificity, and function of skin TRM; and moreover, whether UV-R alters barrier function, leading to microbial-specific skin TRM, disrupting the healthy balance between skin microbiome and skin immune cells, and resulting in chronic inflammation and diseased skin. |
| first_indexed | 2024-12-11T14:38:01Z |
| format | Article |
| id | doaj.art-9062e031a19844b7b19cbda4d2444f50 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T14:38:01Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-9062e031a19844b7b19cbda4d2444f502022-12-22T01:02:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-05-01510.3389/fmed.2018.00166367887A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ CellsVijayKumar Patra0VijayKumar Patra1VijayKumar Patra2Léo Laoubi3Jean-François Nicolas4Jean-François Nicolas5Marc Vocanson6Peter Wolf7Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, FranceCenter for Medical Research, Medical University of Graz, Graz, AustriaResearch Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, AustriaCentre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, FranceCentre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, FranceAllergy and Clinical Immunology Department, Lyon Sud University Hospital, Pierre-Bénite, FranceCentre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, FranceResearch Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, AustriaThe human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). UV-R can promote or inhibit the growth of microbes on the skin and modulate the immune system which can be either favorable or harmful. Among potential UV-R targets, skin resident memory T cells (TRM) stand as well positioned immune cells at the forefront within the skin. Both CD4+ or CD8+ αβ TRM cells residing permanently in peripheral tissues have been shown to play prominent roles in providing accelerated and long-lived specific immunity, tissue homeostasis, wound repair. Nevertheless, their response upon UV-R exposure or signals from microbiome are poorly understood compared to resident TCRγδ cells. Skin TRM survive for long periods of time and are exposed to innumerable antigens during lifetime. The interplay of TRM with skin residing microbes may be crucial in pathophysiology of various diseases including psoriasis, atopic dermatitis and polymorphic light eruption. In this article, we share our perspective about how UV-R may directly shape the persistence, phenotype, specificity, and function of skin TRM; and moreover, whether UV-R alters barrier function, leading to microbial-specific skin TRM, disrupting the healthy balance between skin microbiome and skin immune cells, and resulting in chronic inflammation and diseased skin.https://www.frontiersin.org/article/10.3389/fmed.2018.00166/fullskin microbiomeultraviolet-radiationskin resident memory T cellsinflammationimmune suppressionphotomedicine |
| spellingShingle | VijayKumar Patra VijayKumar Patra VijayKumar Patra Léo Laoubi Jean-François Nicolas Jean-François Nicolas Marc Vocanson Peter Wolf A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells Frontiers in Medicine skin microbiome ultraviolet-radiation skin resident memory T cells inflammation immune suppression photomedicine |
| title | A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells |
| title_full | A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells |
| title_fullStr | A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells |
| title_full_unstemmed | A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells |
| title_short | A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells |
| title_sort | perspective on the interplay of ultraviolet radiation skin microbiome and skin resident memory tcrαβ cells |
| topic | skin microbiome ultraviolet-radiation skin resident memory T cells inflammation immune suppression photomedicine |
| url | https://www.frontiersin.org/article/10.3389/fmed.2018.00166/full |
| work_keys_str_mv | AT vijaykumarpatra aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT vijaykumarpatra aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT vijaykumarpatra aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT leolaoubi aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT jeanfrancoisnicolas aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT jeanfrancoisnicolas aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT marcvocanson aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT peterwolf aperspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT vijaykumarpatra perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT vijaykumarpatra perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT vijaykumarpatra perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT leolaoubi perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT jeanfrancoisnicolas perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT jeanfrancoisnicolas perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT marcvocanson perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells AT peterwolf perspectiveontheinterplayofultravioletradiationskinmicrobiomeandskinresidentmemorytcrabcells |