Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization
We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calc...
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MDPI AG
2012-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/10/1/119/ |
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| author | Chao-Yan Zhang Wen-Hui Wu Jue Wang Min-Bo Lan |
| author_facet | Chao-Yan Zhang Wen-Hui Wu Jue Wang Min-Bo Lan |
| author_sort | Chao-Yan Zhang |
| collection | DOAJ |
| description | We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calcium oxalate monohydrate crystals, using trisodium citrate as a positive control. We assessed antioxidant activities of SGP by determining its reducing power, its ability to scavenge superoxide radicals, and its activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The nucleation inhibition ratio of trisodium citrate and SGP was 58.5 and 69.2%, respectively, and crystal aggregation was inhibited by 71.4 and 76.8%, respectively. Increasing concentrations of SGP resulted in increased scavenging of superoxide anions and DPPH radicals (IC50 = 1.9 and 0.6 mg/mL, respectively). These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization and its antioxidant properties. |
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| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:35:42Z |
| publishDate | 2012-01-01 |
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| spelling | doaj.art-9062f0db74ef443da838014e9b1978fc2022-12-22T04:23:37ZengMDPI AGMarine Drugs1660-33972012-01-0110111913010.3390/md10010119Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate CrystallizationChao-Yan ZhangWen-Hui WuJue WangMin-Bo LanWe investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calcium oxalate monohydrate crystals, using trisodium citrate as a positive control. We assessed antioxidant activities of SGP by determining its reducing power, its ability to scavenge superoxide radicals, and its activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The nucleation inhibition ratio of trisodium citrate and SGP was 58.5 and 69.2%, respectively, and crystal aggregation was inhibited by 71.4 and 76.8%, respectively. Increasing concentrations of SGP resulted in increased scavenging of superoxide anions and DPPH radicals (IC50 = 1.9 and 0.6 mg/mL, respectively). These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization and its antioxidant properties.http://www.mdpi.com/1660-3397/10/1/119/calcium oxalate crystallizationantioxidantpolysaccharideSargassum graminifolium |
| spellingShingle | Chao-Yan Zhang Wen-Hui Wu Jue Wang Min-Bo Lan Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization Marine Drugs calcium oxalate crystallization antioxidant polysaccharide Sargassum graminifolium |
| title | Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization |
| title_full | Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization |
| title_fullStr | Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization |
| title_full_unstemmed | Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization |
| title_short | Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization |
| title_sort | antioxidant properties of polysaccharide from the brown seaweed sargassum graminifolium turn and its effects on calcium oxalate crystallization |
| topic | calcium oxalate crystallization antioxidant polysaccharide Sargassum graminifolium |
| url | http://www.mdpi.com/1660-3397/10/1/119/ |
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