Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein
In this work, cadmium sulfide quantum dots composited with polyamidoamine dendrimer (CdSQDs-PAMAM) thin film had been successfully developed for use in the detection of dengue virus (DENV) E-proteins. Studies involving XRD, EDX, UV–Vis-NIR, and AFM analyses proved the presence of CdSQDs and PAMAM na...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Results in Physics |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211379718320436 |
| _version_ | 1818545790119837696 |
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| author | Nur Alia Sheh Omar Yap Wing Fen Jaafar Abdullah Nur Ain Asyiqin Anas Nur Syahira Md Ramdzan Mohd Adzir Mahdi |
| author_facet | Nur Alia Sheh Omar Yap Wing Fen Jaafar Abdullah Nur Ain Asyiqin Anas Nur Syahira Md Ramdzan Mohd Adzir Mahdi |
| author_sort | Nur Alia Sheh Omar |
| collection | DOAJ |
| description | In this work, cadmium sulfide quantum dots composited with polyamidoamine dendrimer (CdSQDs-PAMAM) thin film had been successfully developed for use in the detection of dengue virus (DENV) E-proteins. Studies involving XRD, EDX, UV–Vis-NIR, and AFM analyses proved the presence of CdSQDs and PAMAM nanoparticles. The mechanism of sensor surface functionalization was confirmed using FTIR spectra. The SPR responses showed a significant shift in resonance angle after exposure to different concentrations of DENV E-protein solution. From this observation, the Au/CdSQDs-PAMAM/IgM sensor film obtained a quantification limit of 0.0001 nM with the association constant of 2.53 × 103 M−1, which was better compared to the Au/IgM and Au/PAMAM/IgM sensor films. The matrix analysis was successfully performed using spiked bovine serum albumin obtaining excellent recovery values in the results. The enhancement of the SPR responses thus showing the high potential of CdSQDs-PAMAM thin film as dengue sensing material in SPR techniques for the future development of dengue diagnostic. Keywords: Cadmium sulfide, Thin film, Quantum dots, PAMAM dendrimer, Surface plasmon resonance |
| first_indexed | 2024-12-12T07:44:38Z |
| format | Article |
| id | doaj.art-906530196e6e4993aa802a2a41dd856a |
| institution | Directory Open Access Journal |
| issn | 2211-3797 |
| language | English |
| last_indexed | 2024-12-12T07:44:38Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Physics |
| spelling | doaj.art-906530196e6e4993aa802a2a41dd856a2022-12-22T00:32:39ZengElsevierResults in Physics2211-37972018-12-0111734739Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-proteinNur Alia Sheh Omar0Yap Wing Fen1Jaafar Abdullah2Nur Ain Asyiqin Anas3Nur Syahira Md Ramdzan4Mohd Adzir Mahdi5Functional Devices Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaFunctional Devices Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Physics, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Corresponding author.Functional Devices Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaFunctional Devices Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaDepartment of Physics, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaWireless and Photonics Network Research Centre, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaIn this work, cadmium sulfide quantum dots composited with polyamidoamine dendrimer (CdSQDs-PAMAM) thin film had been successfully developed for use in the detection of dengue virus (DENV) E-proteins. Studies involving XRD, EDX, UV–Vis-NIR, and AFM analyses proved the presence of CdSQDs and PAMAM nanoparticles. The mechanism of sensor surface functionalization was confirmed using FTIR spectra. The SPR responses showed a significant shift in resonance angle after exposure to different concentrations of DENV E-protein solution. From this observation, the Au/CdSQDs-PAMAM/IgM sensor film obtained a quantification limit of 0.0001 nM with the association constant of 2.53 × 103 M−1, which was better compared to the Au/IgM and Au/PAMAM/IgM sensor films. The matrix analysis was successfully performed using spiked bovine serum albumin obtaining excellent recovery values in the results. The enhancement of the SPR responses thus showing the high potential of CdSQDs-PAMAM thin film as dengue sensing material in SPR techniques for the future development of dengue diagnostic. Keywords: Cadmium sulfide, Thin film, Quantum dots, PAMAM dendrimer, Surface plasmon resonancehttp://www.sciencedirect.com/science/article/pii/S2211379718320436 |
| spellingShingle | Nur Alia Sheh Omar Yap Wing Fen Jaafar Abdullah Nur Ain Asyiqin Anas Nur Syahira Md Ramdzan Mohd Adzir Mahdi Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein Results in Physics |
| title | Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein |
| title_full | Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein |
| title_fullStr | Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein |
| title_full_unstemmed | Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein |
| title_short | Optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus E-protein |
| title_sort | optical and structural properties of cadmium sulphide quantum dots based thin films as potential sensing material for dengue virus e protein |
| url | http://www.sciencedirect.com/science/article/pii/S2211379718320436 |
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