Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration
Total hip arthroplasty (THA) is the most common and radical treatment for end-stage hip disease. Prosthesis loosening and periprosthetic infection are the most serious complications after THA, which may lead to prosthetic dysfunction. The early prevention of infection and the promotion of fast osseo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523000278 |
| _version_ | 1811158453157101568 |
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| author | Xianxing Xu Hailun Xu Qihao Chai Ziyang Li Zhentao Man Wei Li |
| author_facet | Xianxing Xu Hailun Xu Qihao Chai Ziyang Li Zhentao Man Wei Li |
| author_sort | Xianxing Xu |
| collection | DOAJ |
| description | Total hip arthroplasty (THA) is the most common and radical treatment for end-stage hip disease. Prosthesis loosening and periprosthetic infection are the most serious complications after THA, which may lead to prosthetic dysfunction. The early prevention of infection and the promotion of fast osseointegration between the prosthesis and host bone are essential to the success of THA. However, Ti6Al4V does not have biological function, such as promoting osseointegration and antibacterial properties, which limits its widespread use. Therefore, it is necessary to design a functional hip prosthesis to simultaneously reduce the incidence of loosening and periprosthetic infection. In this study, we developed a novel functionalized coating via micro-arc oxidation modification combined with vancomycin to treat a prosthetic surface for the early postoperative period to resist bacterial infection and promote osseointegration. The functionalized coating simultaneously prevents periprosthetic infections and promotes osseointegration at the prosthesis–host bone interface. We successfully constructed a prosthetic coating with the dual function of promoting osseointegration and preventing infection, which provides a practical and effective method for the treatment of periprosthetic infection and prosthetic loosening after THA. |
| first_indexed | 2024-04-10T05:24:56Z |
| format | Article |
| id | doaj.art-9065bbf399354eab8c20a6108514bb84 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T05:24:56Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-9065bbf399354eab8c20a6108514bb842023-03-08T04:13:30ZengElsevierMaterials & Design0264-12752023-02-01226111612Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegrationXianxing Xu0Hailun Xu1Qihao Chai2Ziyang Li3Zhentao Man4Wei Li5Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250021, PR ChinaDepartment of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250021, PR ChinaDepartment of Joint Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province 250021, PR ChinaDepartment of Joint Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province 250021, PR ChinaDepartment of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250021, PR China; Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province 250021, PR China; Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong Province 250062, PR China; Corresponding authors at: Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250021, PR China.Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250021, PR China; Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province 250021, PR China; Corresponding authors at: Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250021, PR China.Total hip arthroplasty (THA) is the most common and radical treatment for end-stage hip disease. Prosthesis loosening and periprosthetic infection are the most serious complications after THA, which may lead to prosthetic dysfunction. The early prevention of infection and the promotion of fast osseointegration between the prosthesis and host bone are essential to the success of THA. However, Ti6Al4V does not have biological function, such as promoting osseointegration and antibacterial properties, which limits its widespread use. Therefore, it is necessary to design a functional hip prosthesis to simultaneously reduce the incidence of loosening and periprosthetic infection. In this study, we developed a novel functionalized coating via micro-arc oxidation modification combined with vancomycin to treat a prosthetic surface for the early postoperative period to resist bacterial infection and promote osseointegration. The functionalized coating simultaneously prevents periprosthetic infections and promotes osseointegration at the prosthesis–host bone interface. We successfully constructed a prosthetic coating with the dual function of promoting osseointegration and preventing infection, which provides a practical and effective method for the treatment of periprosthetic infection and prosthetic loosening after THA.http://www.sciencedirect.com/science/article/pii/S0264127523000278Total hip arthroplastyMicro-arc oxidationVancomycinAntibacterialOsseointegration |
| spellingShingle | Xianxing Xu Hailun Xu Qihao Chai Ziyang Li Zhentao Man Wei Li Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration Materials & Design Total hip arthroplasty Micro-arc oxidation Vancomycin Antibacterial Osseointegration |
| title | Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration |
| title_full | Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration |
| title_fullStr | Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration |
| title_full_unstemmed | Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration |
| title_short | Novel functionalized Ti6Al4V scaffold for preventing infection and promoting rapid osseointegration |
| title_sort | novel functionalized ti6al4v scaffold for preventing infection and promoting rapid osseointegration |
| topic | Total hip arthroplasty Micro-arc oxidation Vancomycin Antibacterial Osseointegration |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523000278 |
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