Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma
ObjectivePD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze its expression and prognostic significance in high-grade salivary gland carcinoma (SGC).MethodsPD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.701181/full |
| _version_ | 1798035786860331008 |
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| author | Qigen Fang Yao Wu Wei Du Xu Zhang Defeng Chen |
| author_facet | Qigen Fang Yao Wu Wei Du Xu Zhang Defeng Chen |
| author_sort | Qigen Fang |
| collection | DOAJ |
| description | ObjectivePD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze its expression and prognostic significance in high-grade salivary gland carcinoma (SGC).MethodsPD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade SGC, and it was scored by the tumor proportion score (TPS), combined positive score (CPS), and immune cell (IC) score. Associations between clinicopathological variables, disease-free survival (DFS), overall survival (OS) and PD-L1 expression were assessed.ResultsTPS≥1% occurred in 47 patients with an incidence of 43.1%, and it was significantly related to an advanced tumor stage. In patients with TPS<1%, TPS ranging from 1% to 20%, and TPS≥20%, the 5-year DFS rates were 36%, 26%, and 13%, respectively, and the difference was significant. In patients with TPS<1%, TPS ranging from 1% to 20%, and TPS≥20%, the 5-year OS rates were 49%, 24%, and 13%, respectively, and the difference was significant. CPS≥1 occurred in 87 patients with an incidence of 79.8%. IC scores of 0, 1, 2, and 3 were noted in 24 (22.0%), 37 (33.9%), 31 (28.4%), and 17 (15.6%) patients, respectively. Both CPS and IC scores had no impact on DFS or OS.ConclusionsThe expression of PD-L1 in tumor cells of high-grade SGCs was not uncommon, and it was significantly associated with tumor stage. PD-L1 expression in tumor cells rather than in immune cells indicated a poor prognosis. |
| first_indexed | 2024-04-11T21:03:06Z |
| format | Article |
| id | doaj.art-9065eb94e01c4f1eb86c7851088b8b42 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T21:03:06Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9065eb94e01c4f1eb86c7851088b8b422022-12-22T04:03:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.701181701181Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland CarcinomaQigen FangYao WuWei DuXu ZhangDefeng ChenObjectivePD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze its expression and prognostic significance in high-grade salivary gland carcinoma (SGC).MethodsPD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade SGC, and it was scored by the tumor proportion score (TPS), combined positive score (CPS), and immune cell (IC) score. Associations between clinicopathological variables, disease-free survival (DFS), overall survival (OS) and PD-L1 expression were assessed.ResultsTPS≥1% occurred in 47 patients with an incidence of 43.1%, and it was significantly related to an advanced tumor stage. In patients with TPS<1%, TPS ranging from 1% to 20%, and TPS≥20%, the 5-year DFS rates were 36%, 26%, and 13%, respectively, and the difference was significant. In patients with TPS<1%, TPS ranging from 1% to 20%, and TPS≥20%, the 5-year OS rates were 49%, 24%, and 13%, respectively, and the difference was significant. CPS≥1 occurred in 87 patients with an incidence of 79.8%. IC scores of 0, 1, 2, and 3 were noted in 24 (22.0%), 37 (33.9%), 31 (28.4%), and 17 (15.6%) patients, respectively. Both CPS and IC scores had no impact on DFS or OS.ConclusionsThe expression of PD-L1 in tumor cells of high-grade SGCs was not uncommon, and it was significantly associated with tumor stage. PD-L1 expression in tumor cells rather than in immune cells indicated a poor prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2021.701181/fullsalivary gland carcinomaPD-L1immunotherapyhigh-grade salivary gland carcinomasurvival |
| spellingShingle | Qigen Fang Yao Wu Wei Du Xu Zhang Defeng Chen Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma Frontiers in Oncology salivary gland carcinoma PD-L1 immunotherapy high-grade salivary gland carcinoma survival |
| title | Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma |
| title_full | Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma |
| title_fullStr | Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma |
| title_full_unstemmed | Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma |
| title_short | Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma |
| title_sort | incidence and prognostic significance of pd l1 expression in high grade salivary gland carcinoma |
| topic | salivary gland carcinoma PD-L1 immunotherapy high-grade salivary gland carcinoma survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.701181/full |
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