The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway

The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway

Liver steatosis is a common metabolic disorder resulting from imbalanced lipid metabolism, which involves various processes such as de novo lipogenesis, fatty acid uptake, fatty acid oxidation, and VLDL secretion. In this study, we discovered that KLF2, a transcription factor, plays a crucial role i...

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Bibliographic Details
Main Authors: Yuhong Huang, Yi Fan Wang, Xiong Zhong Ruan, Chi Wai Lau, Li Wang, Yu Huang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Lipid Research
Subjects:
KLF2
SCAP
SREBPs
steatosis
lipogenesis
blood cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001451

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