Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature
<i>Sphingomonas paucimobilis</i> is a gram-negative bacillus that is widely distributed in the environment but rarely causes infections in humans. Meningitis caused by <i>S. paucimobilis</i> is an extremely rare clinical entity with very few reported cases in the literature....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/4/687 |
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| author | Iosif Marincu Felix Bratosin Iulia Bogdan Catalin Dumitru Carmen Nicoleta Stoica Andrei Nicolae Csep Narcisa Mederle Roxana Manuela Fericean Alexandru Ovidiu Mederle Reshmanth Prathipati Gratiana Nicoleta Chicin Adelina Mavrea Paula Irina Barata Adrian Vasile Bota |
| author_facet | Iosif Marincu Felix Bratosin Iulia Bogdan Catalin Dumitru Carmen Nicoleta Stoica Andrei Nicolae Csep Narcisa Mederle Roxana Manuela Fericean Alexandru Ovidiu Mederle Reshmanth Prathipati Gratiana Nicoleta Chicin Adelina Mavrea Paula Irina Barata Adrian Vasile Bota |
| author_sort | Iosif Marincu |
| collection | DOAJ |
| description | <i>Sphingomonas paucimobilis</i> is a gram-negative bacillus that is widely distributed in the environment but rarely causes infections in humans. Meningitis caused by <i>S. paucimobilis</i> is an extremely rare clinical entity with very few reported cases in the literature. The clinical presentation and management of <i>S. paucimobilis</i> meningitis are not well established, and further research is needed to better understand this rare infection. Therefore, the goal of this study was to present probably the only case of meningitis caused by co-infection with <i>S. paucimobilis</i> and <i>Mycobacterium tuberculosis</i> and to describe the diagnostic and therapeutic challenges encountered, in correlation with the other very few reported cases of <i>S. paucimobilis</i> meningitis. A 64-year-old male farmer residing in a rural area was admitted with symptoms of severe headache, somnolence, and confusion. He had several comorbidities, including adrenal insufficiency, duodenal ulcer, and hypercholesterolemia. Lumbar puncture showed elevated leukocyte counts, glucose, and a marked rise of cerebrospinal fluid (CSF) proteins, indicating bacterial meningitis, which was confirmed by CSF culture that isolated <i>S. paucimobilis</i> and <i>Mycobacterium tuberculosis</i>. Antituberculosis therapy was initiated with isoniazid (300 mg/day), rifampicin (600 mg/day), pyrazinamide (2000 mg/day), and streptomycin (1 g/day). Ceftriaxone was introduced nine days later, after CSF culture grew <i>S. paucimobilis</i>, and was discharged without complications after 40 days of hospitalization. The literature search revealed a total of 12 published cases of <i>S. paucimobilis</i> meningitis in patients ranging from two months old to 66 years old. Among these cases, eight (66%) reported a favorable outcome, while two (17%) cases resulted in a poor outcome, and two (17%) were fatal. It was observed among the 13 identified cases (including ours) that the CSF white blood cell count had an average of 178.9 × 10<sup>3</sup>/mm<sup>3</sup>, an average glucose level of 33.0 mg/dL, and an average protein count of 294.2 mg/dL. Most cases improved appropriately under antibiotic therapy with intravenous ceftriaxone, Meropenem, and Vancomycin. In conclusion, although extremely rare, <i>S. paucimobilis</i> meningitis has good outcomes even in immunocompromised patients with appropriate antibiotic therapy and close monitoring, while the diagnosis should not be excluded even in immunocompetent patients. |
| first_indexed | 2024-03-11T04:46:22Z |
| format | Article |
| id | doaj.art-9068df87f0b24f3db9955e7edb0cde9a |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:46:22Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-9068df87f0b24f3db9955e7edb0cde9a2023-11-17T20:20:32ZengMDPI AGMedicina1010-660X1648-91442023-03-0159468710.3390/medicina59040687Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of LiteratureIosif Marincu0Felix Bratosin1Iulia Bogdan2Catalin Dumitru3Carmen Nicoleta Stoica4Andrei Nicolae Csep5Narcisa Mederle6Roxana Manuela Fericean7Alexandru Ovidiu Mederle8Reshmanth Prathipati9Gratiana Nicoleta Chicin10Adelina Mavrea11Paula Irina Barata12Adrian Vasile Bota13Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDoctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaSantiram Medical College and General Hospital, Nandyala 518001, IndiaFaculty of General Medicine, “Vasile Goldis” Western University of Arad, Bulevardul Revolutiei 94, 310025 Arad, RomaniaDepartment of Internal Medicine I, Cardiology Clinic, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Physiology, Faculty of Medicine, “Vasile Goldis” Western University of Arad, Revolutiei Square 94, 310025 Arad, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania<i>Sphingomonas paucimobilis</i> is a gram-negative bacillus that is widely distributed in the environment but rarely causes infections in humans. Meningitis caused by <i>S. paucimobilis</i> is an extremely rare clinical entity with very few reported cases in the literature. The clinical presentation and management of <i>S. paucimobilis</i> meningitis are not well established, and further research is needed to better understand this rare infection. Therefore, the goal of this study was to present probably the only case of meningitis caused by co-infection with <i>S. paucimobilis</i> and <i>Mycobacterium tuberculosis</i> and to describe the diagnostic and therapeutic challenges encountered, in correlation with the other very few reported cases of <i>S. paucimobilis</i> meningitis. A 64-year-old male farmer residing in a rural area was admitted with symptoms of severe headache, somnolence, and confusion. He had several comorbidities, including adrenal insufficiency, duodenal ulcer, and hypercholesterolemia. Lumbar puncture showed elevated leukocyte counts, glucose, and a marked rise of cerebrospinal fluid (CSF) proteins, indicating bacterial meningitis, which was confirmed by CSF culture that isolated <i>S. paucimobilis</i> and <i>Mycobacterium tuberculosis</i>. Antituberculosis therapy was initiated with isoniazid (300 mg/day), rifampicin (600 mg/day), pyrazinamide (2000 mg/day), and streptomycin (1 g/day). Ceftriaxone was introduced nine days later, after CSF culture grew <i>S. paucimobilis</i>, and was discharged without complications after 40 days of hospitalization. The literature search revealed a total of 12 published cases of <i>S. paucimobilis</i> meningitis in patients ranging from two months old to 66 years old. Among these cases, eight (66%) reported a favorable outcome, while two (17%) cases resulted in a poor outcome, and two (17%) were fatal. It was observed among the 13 identified cases (including ours) that the CSF white blood cell count had an average of 178.9 × 10<sup>3</sup>/mm<sup>3</sup>, an average glucose level of 33.0 mg/dL, and an average protein count of 294.2 mg/dL. Most cases improved appropriately under antibiotic therapy with intravenous ceftriaxone, Meropenem, and Vancomycin. In conclusion, although extremely rare, <i>S. paucimobilis</i> meningitis has good outcomes even in immunocompromised patients with appropriate antibiotic therapy and close monitoring, while the diagnosis should not be excluded even in immunocompetent patients.https://www.mdpi.com/1648-9144/59/4/687meningitis<i>Sphingomonas paucimobilis</i><i>Mycobacterium tuberculosis</i> |
| spellingShingle | Iosif Marincu Felix Bratosin Iulia Bogdan Catalin Dumitru Carmen Nicoleta Stoica Andrei Nicolae Csep Narcisa Mederle Roxana Manuela Fericean Alexandru Ovidiu Mederle Reshmanth Prathipati Gratiana Nicoleta Chicin Adelina Mavrea Paula Irina Barata Adrian Vasile Bota Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature Medicina meningitis <i>Sphingomonas paucimobilis</i> <i>Mycobacterium tuberculosis</i> |
| title | Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature |
| title_full | Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature |
| title_fullStr | Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature |
| title_full_unstemmed | Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature |
| title_short | Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literature |
| title_sort | concurrent i sphingomonas paucimobilis i and i mycobacterium tuberculosis i meningitis in an immunocompromised patient a rare case report and comprehensive review of literature |
| topic | meningitis <i>Sphingomonas paucimobilis</i> <i>Mycobacterium tuberculosis</i> |
| url | https://www.mdpi.com/1648-9144/59/4/687 |
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