A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin
Introduction: Chronic suppurative otitis media is one of the commonest causes of hearing loss. In myringoplasty the most widely used and accepted method is underlay graft of temporalis fascia. Platelet-rich fibrin is a second-generation platelet concentrate; It serves as a resorbable membrane that o...
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| Format: | Article |
| Language: | English |
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Al Ameen Medical College
2022-10-01
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| Series: | Al Ameen Journal of Medical Sciences |
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| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/11%20AJMS%20V15.N4.2022%20p%20319-325.pdf |
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| author | Ashfak Ahmed R. Kakeri Anees Fatima Patel Abam Fasal Govind Mohandas |
| author_facet | Ashfak Ahmed R. Kakeri Anees Fatima Patel Abam Fasal Govind Mohandas |
| author_sort | Ashfak Ahmed R. Kakeri |
| collection | DOAJ |
| description | Introduction: Chronic suppurative otitis media is one of the commonest causes of hearing loss. In myringoplasty the most widely used and accepted method is underlay graft of temporalis fascia. Platelet-rich fibrin is a second-generation platelet concentrate; It serves as a resorbable membrane that offers both mechanical and inflammatory protection to the tympanic membrane graft. It accelerates cell proliferation and matrix remodelling; it does not induce any undesirable tissue reactions. Objectives: To study the efficiency of use of autologous platelet rich fibrin in closure of tympanic membrane perforation during myringoplasty by preventing graft lateralization, graft site infection, promoting quicker healing and improving the overall outcome. Methods: This study included 50 patients presented to the Department of Otorhinolaryngology, Al Ameen Medical College, Vijayapura from November 2019 to December 2021 with chronic suppurative otitis media. 50% of patients underwent myringoplasty with autologous PRF and remaining 50% without PRF, they served as control. Routine follow-up at the 21 days, 1 month and 3 months after surgery. Postoperative PTA was done at 3 months. Results: The graft uptake rate was found to earlier in PRF group at 3 weeks and 1 month in comparison to controls, which was statistically significant (p< 0.05). Conclusion: PRF is a cheap and cost effective platelet concentrate with enriched growth factors. It accelerates the tympanic membrane closure, prevents graft migration, site infection and improves overall success rate in myringoplasty. It has no noticeable side effects. |
| first_indexed | 2024-04-11T17:01:33Z |
| format | Article |
| id | doaj.art-9069328378b246f1af9023adf1233a8a |
| institution | Directory Open Access Journal |
| issn | 0974-1143 |
| language | English |
| last_indexed | 2024-04-11T17:01:33Z |
| publishDate | 2022-10-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-9069328378b246f1af9023adf1233a8a2022-12-22T04:13:09ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432022-10-011504319325A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrinAshfak Ahmed R. Kakeri0Anees Fatima Patel1Abam Fasal2Govind Mohandas3Department of ENT, Al Ameen Medical College and Hospital, Athani Road, Vijayapur-586108, Karnataka, IndiaDepartment of ENT, Al Ameen Medical College and Hospital, Athani Road, Vijayapur-586108, Karnataka, IndiaDepartment of ENT, Al Ameen Medical College and Hospital, Athani Road, Vijayapur-586108, Karnataka, IndiaDepartment of ENT, Al Ameen Medical College and Hospital, Athani Road, Vijayapur-586108, Karnataka, IndiaIntroduction: Chronic suppurative otitis media is one of the commonest causes of hearing loss. In myringoplasty the most widely used and accepted method is underlay graft of temporalis fascia. Platelet-rich fibrin is a second-generation platelet concentrate; It serves as a resorbable membrane that offers both mechanical and inflammatory protection to the tympanic membrane graft. It accelerates cell proliferation and matrix remodelling; it does not induce any undesirable tissue reactions. Objectives: To study the efficiency of use of autologous platelet rich fibrin in closure of tympanic membrane perforation during myringoplasty by preventing graft lateralization, graft site infection, promoting quicker healing and improving the overall outcome. Methods: This study included 50 patients presented to the Department of Otorhinolaryngology, Al Ameen Medical College, Vijayapura from November 2019 to December 2021 with chronic suppurative otitis media. 50% of patients underwent myringoplasty with autologous PRF and remaining 50% without PRF, they served as control. Routine follow-up at the 21 days, 1 month and 3 months after surgery. Postoperative PTA was done at 3 months. Results: The graft uptake rate was found to earlier in PRF group at 3 weeks and 1 month in comparison to controls, which was statistically significant (p< 0.05). Conclusion: PRF is a cheap and cost effective platelet concentrate with enriched growth factors. It accelerates the tympanic membrane closure, prevents graft migration, site infection and improves overall success rate in myringoplasty. It has no noticeable side effects.http://ajms.alameenmedical.org/ArticlePDFs/11%20AJMS%20V15.N4.2022%20p%20319-325.pdfchronic suppurative otitis mediamyringoplastyprfgraft uptakeaudiometry |
| spellingShingle | Ashfak Ahmed R. Kakeri Anees Fatima Patel Abam Fasal Govind Mohandas A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin Al Ameen Journal of Medical Sciences chronic suppurative otitis media myringoplasty prf graft uptake audiometry |
| title | A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin |
| title_full | A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin |
| title_fullStr | A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin |
| title_full_unstemmed | A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin |
| title_short | A comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin |
| title_sort | comparative study of outcome of myrigngoplasty with and without use of autologous platelet rich fibrin |
| topic | chronic suppurative otitis media myringoplasty prf graft uptake audiometry |
| url | http://ajms.alameenmedical.org/ArticlePDFs/11%20AJMS%20V15.N4.2022%20p%20319-325.pdf |
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