Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia
BackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1010273/full |
| _version_ | 1797955363717251072 |
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| author | Malo Gaubert Malo Gaubert Andrea Dell’Orco Andrea Dell’Orco Catharina Lange Catharina Lange Antoine Garnier-Crussard Antoine Garnier-Crussard Antoine Garnier-Crussard Isabella Zimmermann Martin Dyrba Marco Duering Gabriel Ziegler Oliver Peters Oliver Peters Lukas Preis Josef Priller Josef Priller Josef Priller Josef Priller Eike Jakob Spruth Eike Jakob Spruth Anja Schneider Anja Schneider Klaus Fliessbach Klaus Fliessbach Jens Wiltfang Jens Wiltfang Jens Wiltfang Björn H. Schott Björn H. Schott Björn H. Schott Franziska Maier Wenzel Glanz Katharina Buerger Katharina Buerger Daniel Janowitz Robert Perneczky Robert Perneczky Robert Perneczky Robert Perneczky Robert Perneczky Boris-Stephan Rauchmann Stefan Teipel Stefan Teipel Ingo Kilimann Ingo Kilimann Christoph Laske Christoph Laske Matthias H. Munk Matthias H. Munk Annika Spottke Annika Spottke Nina Roy Laura Dobisch Michael Ewers Peter Dechent John Dylan Haynes Klaus Scheffler Emrah Düzel Emrah Düzel Frank Jessen Frank Jessen Frank Jessen Miranka Wirth for the DELCODE study group Amthauer Holger Cetindag Arda Can Cosma Nicoleta Carmen Diesing Dominik Ehrlich Marie Fenski Frederike Freiesleben Silka Dawn Fuentes Manuel Hauser Dietmar Hujer Nicole Incesoy Enise Irem Kainz Christian Lange Catharina Lindner Katja Megges Herlind Peters Oliver Preis Lukas Altenstein Slawek Lohse Andrea Franke Christiana Priller Josef Spruth Eike Villar Munoz Irene Barkhoff Miriam Boecker Henning Brosseron Frederic Daamen Marcel Engels Tanja Faber Jennifer Fließbach Klaus Frommann Ingo Grobe-Einsler Marcus Hennes Guido Herrmann Gabi Jost Lorraine Kalbhen Pascal Kimmich Okka Kobeleva Xenia Kofler Barbara McCormick Cornelia Miebach Lisa Miklitz Carolin Müller Anna Oender Demet Polcher Alexandra Purrer Veronika Röske Sandra Schneider Christine Schneider Anja Spottke Annika Vogt Ina Wagner Michael wolfsgruber Steffen Yilmaz Sagik Bartels Claudia Dechent Peter Hansen Niels Hassoun Lina Hirschel Sina Nuhn Sabine Pfahlert Ilona Rausch Lena Schott Björn Timäus Charles Werner Christine Wiltfang Jens Zabel Lioba Zech Heike Bader Abdelmajid Baldermann Juan Carlos Dölle Britta Drzezga Alexander Escher Claus Ghiasi Nasim Roshan Hardenacke Katja Jessen Frank Lützerath Hannah Maier Franziska Marquardt Benjamin Martikke Anja Meiberth Dix Petzler Snjezana Rostamzadeh Ayda Sannemann Lena Schild Ann-Katrin Sorgalla Susanne Stockter Simone Thelen Manuela Tscheuschler Maike Uhle Franziska Zeyen Philip Bittner Daniel Cardenas-Blanco Arturo Dobisch Laura Düzel Emrah Grieger-Klose Doreen Hartmann Deike Metzger Coraline Nestor Peter Ruß Christin Schulze Franziska Speck Oliver Wenzel Glanz Yakupov Renat Ziegler Gabriel Brauneis Christine Bürger Katharina Catak Cihan Coloma Andrews Lisa Dichgans Martin Dörr Angelika Ertl-Wagner Birgit Frimmer Daniela Huber Brigitte Janowitz Daniel Kreuzer Max Markov Eva Müller Claudia Rominger Axel Schmid (ehemals Spreider) Jennifer Seegerer Anna Stephan Julia Zollver Adelgunde Burow Lena de Jonge Sylvia Falkai Peter Garcia Angarita Natalie Görlitz Thomas Gürsel Selim Üstün Horvath Ildiko Kurz Carolin Meisenzahl-Lechner Eva Perneczky Robert Utecht Julia Dyrba Martin Janecek-Meyer Heike Kilimann Ingo Lappe Chris Lau Esther Pfaff Henrike Raum Heike Sabik Petr Schmidt Monika Schulz Heike Schwarzenboeck Sarah Teipel Stefan Weber Marc-Andre Buchmann Martina Heger Tanja Hinderer Petra Kuder-Buletta Elke Laske Christoph Munk Matthias Mychajliw Christian Soekadar Surjo sulzer Patricia Trunk Theresia |
| author_facet | Malo Gaubert Malo Gaubert Andrea Dell’Orco Andrea Dell’Orco Catharina Lange Catharina Lange Antoine Garnier-Crussard Antoine Garnier-Crussard Antoine Garnier-Crussard Isabella Zimmermann Martin Dyrba Marco Duering Gabriel Ziegler Oliver Peters Oliver Peters Lukas Preis Josef Priller Josef Priller Josef Priller Josef Priller Eike Jakob Spruth Eike Jakob Spruth Anja Schneider Anja Schneider Klaus Fliessbach Klaus Fliessbach Jens Wiltfang Jens Wiltfang Jens Wiltfang Björn H. Schott Björn H. Schott Björn H. Schott Franziska Maier Wenzel Glanz Katharina Buerger Katharina Buerger Daniel Janowitz Robert Perneczky Robert Perneczky Robert Perneczky Robert Perneczky Robert Perneczky Boris-Stephan Rauchmann Stefan Teipel Stefan Teipel Ingo Kilimann Ingo Kilimann Christoph Laske Christoph Laske Matthias H. Munk Matthias H. Munk Annika Spottke Annika Spottke Nina Roy Laura Dobisch Michael Ewers Peter Dechent John Dylan Haynes Klaus Scheffler Emrah Düzel Emrah Düzel Frank Jessen Frank Jessen Frank Jessen Miranka Wirth for the DELCODE study group Amthauer Holger Cetindag Arda Can Cosma Nicoleta Carmen Diesing Dominik Ehrlich Marie Fenski Frederike Freiesleben Silka Dawn Fuentes Manuel Hauser Dietmar Hujer Nicole Incesoy Enise Irem Kainz Christian Lange Catharina Lindner Katja Megges Herlind Peters Oliver Preis Lukas Altenstein Slawek Lohse Andrea Franke Christiana Priller Josef Spruth Eike Villar Munoz Irene Barkhoff Miriam Boecker Henning Brosseron Frederic Daamen Marcel Engels Tanja Faber Jennifer Fließbach Klaus Frommann Ingo Grobe-Einsler Marcus Hennes Guido Herrmann Gabi Jost Lorraine Kalbhen Pascal Kimmich Okka Kobeleva Xenia Kofler Barbara McCormick Cornelia Miebach Lisa Miklitz Carolin Müller Anna Oender Demet Polcher Alexandra Purrer Veronika Röske Sandra Schneider Christine Schneider Anja Spottke Annika Vogt Ina Wagner Michael wolfsgruber Steffen Yilmaz Sagik Bartels Claudia Dechent Peter Hansen Niels Hassoun Lina Hirschel Sina Nuhn Sabine Pfahlert Ilona Rausch Lena Schott Björn Timäus Charles Werner Christine Wiltfang Jens Zabel Lioba Zech Heike Bader Abdelmajid Baldermann Juan Carlos Dölle Britta Drzezga Alexander Escher Claus Ghiasi Nasim Roshan Hardenacke Katja Jessen Frank Lützerath Hannah Maier Franziska Marquardt Benjamin Martikke Anja Meiberth Dix Petzler Snjezana Rostamzadeh Ayda Sannemann Lena Schild Ann-Katrin Sorgalla Susanne Stockter Simone Thelen Manuela Tscheuschler Maike Uhle Franziska Zeyen Philip Bittner Daniel Cardenas-Blanco Arturo Dobisch Laura Düzel Emrah Grieger-Klose Doreen Hartmann Deike Metzger Coraline Nestor Peter Ruß Christin Schulze Franziska Speck Oliver Wenzel Glanz Yakupov Renat Ziegler Gabriel Brauneis Christine Bürger Katharina Catak Cihan Coloma Andrews Lisa Dichgans Martin Dörr Angelika Ertl-Wagner Birgit Frimmer Daniela Huber Brigitte Janowitz Daniel Kreuzer Max Markov Eva Müller Claudia Rominger Axel Schmid (ehemals Spreider) Jennifer Seegerer Anna Stephan Julia Zollver Adelgunde Burow Lena de Jonge Sylvia Falkai Peter Garcia Angarita Natalie Görlitz Thomas Gürsel Selim Üstün Horvath Ildiko Kurz Carolin Meisenzahl-Lechner Eva Perneczky Robert Utecht Julia Dyrba Martin Janecek-Meyer Heike Kilimann Ingo Lappe Chris Lau Esther Pfaff Henrike Raum Heike Sabik Petr Schmidt Monika Schulz Heike Schwarzenboeck Sarah Teipel Stefan Weber Marc-Andre Buchmann Martina Heger Tanja Hinderer Petra Kuder-Buletta Elke Laske Christoph Munk Matthias Mychajliw Christian Soekadar Surjo sulzer Patricia Trunk Theresia |
| author_sort | Malo Gaubert |
| collection | DOAJ |
| description | BackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive impairment and AD, appropriate automated WMH segmentation algorithms are required. This study aimed to compare the performance of segmentation tools and provide information on their application in multicenter research.MethodsWe used a pseudo-randomly selected dataset (n = 50) from the DZNE-multicenter observational Longitudinal Cognitive Impairment and Dementia Study (DELCODE) that included 3D fluid-attenuated inversion recovery (FLAIR) images from participants across the cognitive continuum. Performances of top-rated algorithms for automated WMH segmentation [Brain Intensity Abnormality Classification Algorithm (BIANCA), lesion segmentation toolbox (LST), lesion growth algorithm (LGA), LST lesion prediction algorithm (LPA), pgs, and sysu_media] were compared to manual reference segmentation (RS).ResultsAcross tools, segmentation performance was moderate for global WMH volume and number of detected lesions. After retraining on a DELCODE subset, the deep learning algorithm sysu_media showed the highest performances with an average Dice’s coefficient of 0.702 (±0.109 SD) for volume and a mean F1-score of 0.642 (±0.109 SD) for the number of lesions. The intra-class correlation was excellent for all algorithms (>0.9) but BIANCA (0.835). Performance improved with high WMH burden and varied across brain regions.ConclusionTo conclude, the deep learning algorithm, when retrained, performed well in the multicenter context. Nevertheless, the performance was close to traditional methods. We provide methodological recommendations for future studies using automated WMH segmentation to quantify and assess WMH along the continuum of cognitive impairment and AD dementia. |
| first_indexed | 2024-04-10T23:31:56Z |
| format | Article |
| id | doaj.art-906b6b5e5c8d4a04a7d1427ab0aab040 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T23:31:56Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-906b6b5e5c8d4a04a7d1427ab0aab0402023-01-12T05:02:24ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011310.3389/fpsyt.2022.10102731010273Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementiaMalo Gaubert0Malo Gaubert1Andrea Dell’Orco2Andrea Dell’Orco3Catharina Lange4Catharina Lange5Antoine Garnier-Crussard6Antoine Garnier-Crussard7Antoine Garnier-Crussard8Isabella Zimmermann9Martin Dyrba10Marco Duering11Gabriel Ziegler12Oliver Peters13Oliver Peters14Lukas Preis15Josef Priller16Josef Priller17Josef Priller18Josef Priller19Eike Jakob Spruth20Eike Jakob Spruth21Anja Schneider22Anja Schneider23Klaus Fliessbach24Klaus Fliessbach25Jens Wiltfang26Jens Wiltfang27Jens Wiltfang28Björn H. Schott29Björn H. Schott30Björn H. Schott31Franziska Maier32Wenzel Glanz33Katharina Buerger34Katharina Buerger35Daniel Janowitz36Robert Perneczky37Robert Perneczky38Robert Perneczky39Robert Perneczky40Robert Perneczky41Boris-Stephan Rauchmann42Stefan Teipel43Stefan Teipel44Ingo Kilimann45Ingo Kilimann46Christoph Laske47Christoph Laske48Matthias H. Munk49Matthias H. Munk50Annika Spottke51Annika Spottke52Nina Roy53Laura Dobisch54Michael Ewers55Peter Dechent56John Dylan Haynes57Klaus Scheffler58Emrah Düzel59Emrah Düzel60Frank Jessen61Frank Jessen62Frank Jessen63Miranka Wirth64for the DELCODE study groupAmthauer HolgerCetindag Arda CanCosma Nicoleta CarmenDiesing DominikEhrlich MarieFenski FrederikeFreiesleben Silka DawnFuentes ManuelHauser DietmarHujer NicoleIncesoy Enise IremKainz ChristianLange CatharinaLindner KatjaMegges HerlindPeters OliverPreis LukasAltenstein SlawekLohse AndreaFranke ChristianaPriller JosefSpruth EikeVillar Munoz IreneBarkhoff MiriamBoecker HenningBrosseron FredericDaamen MarcelEngels TanjaFaber JenniferFließbach KlausFrommann IngoGrobe-Einsler MarcusHennes GuidoHerrmann GabiJost LorraineKalbhen PascalKimmich OkkaKobeleva XeniaKofler BarbaraMcCormick CorneliaMiebach LisaMiklitz CarolinMüller AnnaOender DemetPolcher AlexandraPurrer VeronikaRöske SandraSchneider ChristineSchneider AnjaSpottke AnnikaVogt InaWagner Michaelwolfsgruber SteffenYilmaz SagikBartels ClaudiaDechent PeterHansen NielsHassoun LinaHirschel SinaNuhn SabinePfahlert IlonaRausch LenaSchott BjörnTimäus CharlesWerner ChristineWiltfang JensZabel LiobaZech HeikeBader AbdelmajidBaldermann Juan CarlosDölle BrittaDrzezga AlexanderEscher ClausGhiasi Nasim RoshanHardenacke KatjaJessen FrankLützerath HannahMaier FranziskaMarquardt BenjaminMartikke AnjaMeiberth DixPetzler SnjezanaRostamzadeh AydaSannemann LenaSchild Ann-KatrinSorgalla SusanneStockter SimoneThelen ManuelaTscheuschler MaikeUhle FranziskaZeyen PhilipBittner DanielCardenas-Blanco ArturoDobisch LauraDüzel EmrahGrieger-Klose DoreenHartmann DeikeMetzger CoralineNestor PeterRuß ChristinSchulze FranziskaSpeck OliverWenzel GlanzYakupov RenatZiegler GabrielBrauneis ChristineBürger KatharinaCatak CihanColoma Andrews LisaDichgans MartinDörr AngelikaErtl-Wagner BirgitFrimmer DanielaHuber BrigitteJanowitz DanielKreuzer MaxMarkov EvaMüller ClaudiaRominger AxelSchmid (ehemals Spreider) JenniferSeegerer AnnaStephan JuliaZollver AdelgundeBurow Lenade Jonge SylviaFalkai PeterGarcia Angarita NatalieGörlitz ThomasGürsel Selim ÜstünHorvath IldikoKurz CarolinMeisenzahl-Lechner EvaPerneczky RobertUtecht JuliaDyrba MartinJanecek-Meyer HeikeKilimann IngoLappe ChrisLau EstherPfaff HenrikeRaum HeikeSabik PetrSchmidt MonikaSchulz HeikeSchwarzenboeck SarahTeipel StefanWeber Marc-AndreBuchmann MartinaHeger TanjaHinderer PetraKuder-Buletta ElkeLaske ChristophMunk MatthiasMychajliw ChristianSoekadar Surjosulzer PatriciaTrunk TheresiaGerman Center for Neurodegenerative Diseases, Dresden, GermanyDepartment of Neuroradiology, Rennes University Hospital (CHU), Rennes, FranceGerman Center for Neurodegenerative Diseases, Dresden, GermanyDepartment of Neuroradiology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyGerman Center for Neurodegenerative Diseases, Dresden, GermanyDepartment of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyClinical and Research Memory Center of Lyon, Lyon Institute for Elderly, Hospices Civils de Lyon, Lyon, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders,” Institut Blood and Brain @ Caen-Normandie, Caen, FranceNeuroscience Research Centre of Lyon, INSERM 1048, CNRS 5292, Lyon, FranceGerman Center for Neurodegenerative Diseases, Dresden, GermanyGerman Center for Neurodegenerative Diseases, Rostock, GermanyDepartment of Biomedical Engineering, Medical Image Analysis Center (MIAC) and qbig, University of Basel, Basel, Switzerland0German Center for Neurodegenerative Diseases, Magdeburg, Germany1German Center for Neurodegenerative Diseases, Berlin, Germany2Department of Psychiatry, Charité – Universitätsmedizin Berlin, Berlin, Germany2Department of Psychiatry, Charité – Universitätsmedizin Berlin, Berlin, Germany1German Center for Neurodegenerative Diseases, Berlin, Germany3Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany4Centre for Clinical Brain Sciences, University of Edinburgh and UK Dementia Research Institute (DRI), Edinburgh, United Kingdom5Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich, Germany1German Center for Neurodegenerative Diseases, Berlin, Germany3Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany6German Center for Neurodegenerative Diseases, Bonn, Germany7Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany6German Center for Neurodegenerative Diseases, Bonn, Germany7Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany8German Center for Neurodegenerative Diseases, Göttingen, Germany9Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany0Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal8German Center for Neurodegenerative Diseases, Göttingen, Germany9Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany1Leibniz Institute for Neurobiology, Magdeburg, Germany2Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany0German Center for Neurodegenerative Diseases, Magdeburg, Germany3German Center for Neurodegenerative Diseases, Munich, Germany4Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany4Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany3German Center for Neurodegenerative Diseases, Munich, Germany4Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany5Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany6Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, United Kingdom7Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom4Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich (LMU), Munich, GermanyGerman Center for Neurodegenerative Diseases, Rostock, Germany8Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, GermanyGerman Center for Neurodegenerative Diseases, Rostock, Germany8Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany9German Center for Neurodegenerative Diseases, Tübingen, Germany0Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany9German Center for Neurodegenerative Diseases, Tübingen, Germany0Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany6German Center for Neurodegenerative Diseases, Bonn, Germany1Department of Neurology, University of Bonn, Bonn, Germany6German Center for Neurodegenerative Diseases, Bonn, Germany0German Center for Neurodegenerative Diseases, Magdeburg, Germany3German Center for Neurodegenerative Diseases, Munich, Germany2MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University of Göttingen, Göttingen, Germany3Bernstein Center for Computational Neuroscience, Charité – Universitätsmedizin, Berlin, Germany4Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany0German Center for Neurodegenerative Diseases, Magdeburg, Germany5Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany6German Center for Neurodegenerative Diseases, Bonn, Germany2Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany6Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, GermanyGerman Center for Neurodegenerative Diseases, Dresden, GermanyBackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive impairment and AD, appropriate automated WMH segmentation algorithms are required. This study aimed to compare the performance of segmentation tools and provide information on their application in multicenter research.MethodsWe used a pseudo-randomly selected dataset (n = 50) from the DZNE-multicenter observational Longitudinal Cognitive Impairment and Dementia Study (DELCODE) that included 3D fluid-attenuated inversion recovery (FLAIR) images from participants across the cognitive continuum. Performances of top-rated algorithms for automated WMH segmentation [Brain Intensity Abnormality Classification Algorithm (BIANCA), lesion segmentation toolbox (LST), lesion growth algorithm (LGA), LST lesion prediction algorithm (LPA), pgs, and sysu_media] were compared to manual reference segmentation (RS).ResultsAcross tools, segmentation performance was moderate for global WMH volume and number of detected lesions. After retraining on a DELCODE subset, the deep learning algorithm sysu_media showed the highest performances with an average Dice’s coefficient of 0.702 (±0.109 SD) for volume and a mean F1-score of 0.642 (±0.109 SD) for the number of lesions. The intra-class correlation was excellent for all algorithms (>0.9) but BIANCA (0.835). Performance improved with high WMH burden and varied across brain regions.ConclusionTo conclude, the deep learning algorithm, when retrained, performed well in the multicenter context. Nevertheless, the performance was close to traditional methods. We provide methodological recommendations for future studies using automated WMH segmentation to quantify and assess WMH along the continuum of cognitive impairment and AD dementia.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1010273/fullwhite matter hyperintensities segmentationevaluationFLAIRdeep learningagingAlzheimer’s disease |
| spellingShingle | Malo Gaubert Malo Gaubert Andrea Dell’Orco Andrea Dell’Orco Catharina Lange Catharina Lange Antoine Garnier-Crussard Antoine Garnier-Crussard Antoine Garnier-Crussard Isabella Zimmermann Martin Dyrba Marco Duering Gabriel Ziegler Oliver Peters Oliver Peters Lukas Preis Josef Priller Josef Priller Josef Priller Josef Priller Eike Jakob Spruth Eike Jakob Spruth Anja Schneider Anja Schneider Klaus Fliessbach Klaus Fliessbach Jens Wiltfang Jens Wiltfang Jens Wiltfang Björn H. Schott Björn H. Schott Björn H. Schott Franziska Maier Wenzel Glanz Katharina Buerger Katharina Buerger Daniel Janowitz Robert Perneczky Robert Perneczky Robert Perneczky Robert Perneczky Robert Perneczky Boris-Stephan Rauchmann Stefan Teipel Stefan Teipel Ingo Kilimann Ingo Kilimann Christoph Laske Christoph Laske Matthias H. Munk Matthias H. Munk Annika Spottke Annika Spottke Nina Roy Laura Dobisch Michael Ewers Peter Dechent John Dylan Haynes Klaus Scheffler Emrah Düzel Emrah Düzel Frank Jessen Frank Jessen Frank Jessen Miranka Wirth for the DELCODE study group Amthauer Holger Cetindag Arda Can Cosma Nicoleta Carmen Diesing Dominik Ehrlich Marie Fenski Frederike Freiesleben Silka Dawn Fuentes Manuel Hauser Dietmar Hujer Nicole Incesoy Enise Irem Kainz Christian Lange Catharina Lindner Katja Megges Herlind Peters Oliver Preis Lukas Altenstein Slawek Lohse Andrea Franke Christiana Priller Josef Spruth Eike Villar Munoz Irene Barkhoff Miriam Boecker Henning Brosseron Frederic Daamen Marcel Engels Tanja Faber Jennifer Fließbach Klaus Frommann Ingo Grobe-Einsler Marcus Hennes Guido Herrmann Gabi Jost Lorraine Kalbhen Pascal Kimmich Okka Kobeleva Xenia Kofler Barbara McCormick Cornelia Miebach Lisa Miklitz Carolin Müller Anna Oender Demet Polcher Alexandra Purrer Veronika Röske Sandra Schneider Christine Schneider Anja Spottke Annika Vogt Ina Wagner Michael wolfsgruber Steffen Yilmaz Sagik Bartels Claudia Dechent Peter Hansen Niels Hassoun Lina Hirschel Sina Nuhn Sabine Pfahlert Ilona Rausch Lena Schott Björn Timäus Charles Werner Christine Wiltfang Jens Zabel Lioba Zech Heike Bader Abdelmajid Baldermann Juan Carlos Dölle Britta Drzezga Alexander Escher Claus Ghiasi Nasim Roshan Hardenacke Katja Jessen Frank Lützerath Hannah Maier Franziska Marquardt Benjamin Martikke Anja Meiberth Dix Petzler Snjezana Rostamzadeh Ayda Sannemann Lena Schild Ann-Katrin Sorgalla Susanne Stockter Simone Thelen Manuela Tscheuschler Maike Uhle Franziska Zeyen Philip Bittner Daniel Cardenas-Blanco Arturo Dobisch Laura Düzel Emrah Grieger-Klose Doreen Hartmann Deike Metzger Coraline Nestor Peter Ruß Christin Schulze Franziska Speck Oliver Wenzel Glanz Yakupov Renat Ziegler Gabriel Brauneis Christine Bürger Katharina Catak Cihan Coloma Andrews Lisa Dichgans Martin Dörr Angelika Ertl-Wagner Birgit Frimmer Daniela Huber Brigitte Janowitz Daniel Kreuzer Max Markov Eva Müller Claudia Rominger Axel Schmid (ehemals Spreider) Jennifer Seegerer Anna Stephan Julia Zollver Adelgunde Burow Lena de Jonge Sylvia Falkai Peter Garcia Angarita Natalie Görlitz Thomas Gürsel Selim Üstün Horvath Ildiko Kurz Carolin Meisenzahl-Lechner Eva Perneczky Robert Utecht Julia Dyrba Martin Janecek-Meyer Heike Kilimann Ingo Lappe Chris Lau Esther Pfaff Henrike Raum Heike Sabik Petr Schmidt Monika Schulz Heike Schwarzenboeck Sarah Teipel Stefan Weber Marc-Andre Buchmann Martina Heger Tanja Hinderer Petra Kuder-Buletta Elke Laske Christoph Munk Matthias Mychajliw Christian Soekadar Surjo sulzer Patricia Trunk Theresia Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia Frontiers in Psychiatry white matter hyperintensities segmentation evaluation FLAIR deep learning aging Alzheimer’s disease |
| title | Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia |
| title_full | Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia |
| title_fullStr | Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia |
| title_full_unstemmed | Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia |
| title_short | Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia |
| title_sort | performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia |
| topic | white matter hyperintensities segmentation evaluation FLAIR deep learning aging Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1010273/full |
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performanceevaluationofautomatedwhitematterhyperintensitysegmentationalgorithmsinamulticentercohortoncognitiveimpairmentanddementia |