Prognostic significance of mutated genes in megakaryocytic disorders
Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was cond...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Oncology Reviews |
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| Online Access: | https://www.oncologyreviews.org/index.php/or/article/view/408 |
| _version_ | 1828073593586581504 |
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| author | Ali Amin Asnafi Mohammad bagher Mohammadi Hadi Rezaeeyan Nader Davari Najmaldin Saki |
| author_facet | Ali Amin Asnafi Mohammad bagher Mohammadi Hadi Rezaeeyan Nader Davari Najmaldin Saki |
| author_sort | Ali Amin Asnafi |
| collection | DOAJ |
| description | Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was conducted to investigate the oncogenes and tumor suppressor genes as well as their mutations during the megakaryopoiesis process, which can lead to megakaryocytic disorders. Relevant literature was identified by a PubMed search (1998-2019) of English language papers using the terms ‘Megakaryopoiesis’, ‘Mutation’, ‘oncogenes’, and ‘Tumor Suppressor’. According to investigations, several mutations occur in the genes implicated in megakaryopoiesis, which abnormally induce or inhibit megakaryocyte production, differentiation, and maturation, leading to platelet disorders. GATA-1 is one of the important genes in megakaryopoiesis and its mutations can be considered among the factors involved in the incidence of these disorders. Considering the essential role of these genes (such as GATA- 1) in megakaryopoiesis and the involvement of their mutations in platelet disorders, study and examination of these changes can be a positive step in the diagnosis and prognosis of these diseases. |
| first_indexed | 2024-04-11T01:31:38Z |
| format | Article |
| id | doaj.art-906c61607b414b2580de0938212bfbc2 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:31:38Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-906c61607b414b2580de0938212bfbc22023-01-03T09:35:32ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652019-07-0113210.4081/oncol.2019.408Prognostic significance of mutated genes in megakaryocytic disordersAli Amin Asnafi0Mohammad bagher Mohammadi1Hadi Rezaeeyan2Nader Davari3Najmaldin Saki4Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazMegakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was conducted to investigate the oncogenes and tumor suppressor genes as well as their mutations during the megakaryopoiesis process, which can lead to megakaryocytic disorders. Relevant literature was identified by a PubMed search (1998-2019) of English language papers using the terms ‘Megakaryopoiesis’, ‘Mutation’, ‘oncogenes’, and ‘Tumor Suppressor’. According to investigations, several mutations occur in the genes implicated in megakaryopoiesis, which abnormally induce or inhibit megakaryocyte production, differentiation, and maturation, leading to platelet disorders. GATA-1 is one of the important genes in megakaryopoiesis and its mutations can be considered among the factors involved in the incidence of these disorders. Considering the essential role of these genes (such as GATA- 1) in megakaryopoiesis and the involvement of their mutations in platelet disorders, study and examination of these changes can be a positive step in the diagnosis and prognosis of these diseases.https://www.oncologyreviews.org/index.php/or/article/view/408Megakaryocytic disorders. |
| spellingShingle | Ali Amin Asnafi Mohammad bagher Mohammadi Hadi Rezaeeyan Nader Davari Najmaldin Saki Prognostic significance of mutated genes in megakaryocytic disorders Oncology Reviews Megakaryocytic disorders. |
| title | Prognostic significance of mutated genes in megakaryocytic disorders |
| title_full | Prognostic significance of mutated genes in megakaryocytic disorders |
| title_fullStr | Prognostic significance of mutated genes in megakaryocytic disorders |
| title_full_unstemmed | Prognostic significance of mutated genes in megakaryocytic disorders |
| title_short | Prognostic significance of mutated genes in megakaryocytic disorders |
| title_sort | prognostic significance of mutated genes in megakaryocytic disorders |
| topic | Megakaryocytic disorders. |
| url | https://www.oncologyreviews.org/index.php/or/article/view/408 |
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