Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis
Abstract Background To evaluate the possible predictive value and clinicopathological characteristics of Delphian lymph node metastasis in papillary thyroid carcinoma. Methods A retrospective analysis of papillary thyroid carcinoma patients with Delphian lymph node metastasis in a single institution...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | http://link.springer.com/article/10.1186/s40463-019-0362-7 |
| _version_ | 1797967044349526016 |
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| author | Bin Wang Xing-zhu Wen Wei Zhang Ming Qiu |
| author_facet | Bin Wang Xing-zhu Wen Wei Zhang Ming Qiu |
| author_sort | Bin Wang |
| collection | DOAJ |
| description | Abstract Background To evaluate the possible predictive value and clinicopathological characteristics of Delphian lymph node metastasis in papillary thyroid carcinoma. Methods A retrospective analysis of papillary thyroid carcinoma patients with Delphian lymph node metastasis in a single institution and meta-analysis of literature reports were performed. Results In own series, Delphian lymph node metastasis was detected in 19 (9.9%) of 192 papillary thyroid carcinoma patients and was significantly associated with tumor size≥1 cm (P = 0.003), multifocality (P = 0.006) and extrathyroid extension (P < 0.001) in the multivariate analysis. Female was a protective factor for Delphian lymph node metastasis (P = 0.001). Delphian lymph node metastasis was highly predictive of further central lymph node metastasis (positive predictive value = 89.5%, negative predictive value = 67.6%) and moderately predictive of lateral lymph node metastasis (positive predictive value = 26.3%, negative predictive value = 95.4%). In this meta-analysis, there was a strong correlation between Delphian lymph node metastasis and aggressive clinicopathologic characteristics with regards to multifocality (P = 0.0008), bilaterality (P = 0.04), extrathyroid extension (P < 0.00001), lymphovascular invasion (P < 0.00001), further central lymph node metastasis (P < 0.00001) and lateral lymph node metastasis (P < 0.00001). Conclusions This single-institution observational study and meta-analysis identified that Delphian lymph node metastasis was significantly associated with unfavorable clinicopathological characteristics and had a strong predictive power for further disease in the central compartment. Trial registration The clinical study was retrospectively registered to UMIN clinical trials registry (the registry number: UMIN000033835). |
| first_indexed | 2024-04-11T02:23:52Z |
| format | Article |
| id | doaj.art-906c926d151747619de67905da45bca4 |
| institution | Directory Open Access Journal |
| issn | 1916-0216 |
| language | English |
| last_indexed | 2024-04-11T02:23:52Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj.art-906c926d151747619de67905da45bca42023-01-02T22:57:25ZengBMCJournal of Otolaryngology - Head and Neck Surgery1916-02162019-08-014811910.1186/s40463-019-0362-7Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysisBin Wang0Xing-zhu Wen1Wei Zhang2Ming Qiu3Department of General Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of General Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of General Surgery, Changzheng Hospital, Second Military Medical UniversityDepartment of General Surgery, Changzheng Hospital, Second Military Medical UniversityAbstract Background To evaluate the possible predictive value and clinicopathological characteristics of Delphian lymph node metastasis in papillary thyroid carcinoma. Methods A retrospective analysis of papillary thyroid carcinoma patients with Delphian lymph node metastasis in a single institution and meta-analysis of literature reports were performed. Results In own series, Delphian lymph node metastasis was detected in 19 (9.9%) of 192 papillary thyroid carcinoma patients and was significantly associated with tumor size≥1 cm (P = 0.003), multifocality (P = 0.006) and extrathyroid extension (P < 0.001) in the multivariate analysis. Female was a protective factor for Delphian lymph node metastasis (P = 0.001). Delphian lymph node metastasis was highly predictive of further central lymph node metastasis (positive predictive value = 89.5%, negative predictive value = 67.6%) and moderately predictive of lateral lymph node metastasis (positive predictive value = 26.3%, negative predictive value = 95.4%). In this meta-analysis, there was a strong correlation between Delphian lymph node metastasis and aggressive clinicopathologic characteristics with regards to multifocality (P = 0.0008), bilaterality (P = 0.04), extrathyroid extension (P < 0.00001), lymphovascular invasion (P < 0.00001), further central lymph node metastasis (P < 0.00001) and lateral lymph node metastasis (P < 0.00001). Conclusions This single-institution observational study and meta-analysis identified that Delphian lymph node metastasis was significantly associated with unfavorable clinicopathological characteristics and had a strong predictive power for further disease in the central compartment. Trial registration The clinical study was retrospectively registered to UMIN clinical trials registry (the registry number: UMIN000033835).http://link.springer.com/article/10.1186/s40463-019-0362-7Delphian lymph nodePapillary thyroid carcinomaClinical characteristics |
| spellingShingle | Bin Wang Xing-zhu Wen Wei Zhang Ming Qiu Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis Journal of Otolaryngology - Head and Neck Surgery Delphian lymph node Papillary thyroid carcinoma Clinical characteristics |
| title | Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis |
| title_full | Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis |
| title_fullStr | Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis |
| title_full_unstemmed | Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis |
| title_short | Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis |
| title_sort | clinical implications of delphian lymph node metastasis in papillary thyroid carcinoma a single institution study systemic review and meta analysis |
| topic | Delphian lymph node Papillary thyroid carcinoma Clinical characteristics |
| url | http://link.springer.com/article/10.1186/s40463-019-0362-7 |
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