Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias
Various autoantibodies are associated with clinical outcomes in patients with idiopathic interstitial pneumonias (IIPs). We retrospectively analyzed the association between autoantibodies and malignancies in IIP patients. Comprehensive analyses of autoantibodies were performed using immunoprecipitat...
| প্রধান লেখক: | , , , , , , , , , , , , , , |
|---|---|
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
MDPI AG
2022-10-01
|
| মালা: | Biomedicines |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.mdpi.com/2227-9059/10/10/2469 |
| _version_ | 1827651393930919936 |
|---|---|
| author | Takuma Koga Masaki Okamoto Minoru Satoh Kiminori Fujimoto Yoshiaki Zaizen Tomonori Chikasue Akiko Sumi Shinjiro Kaieda Norikazu Matsuo Goushi Matama Takashi Nouno Masaki Tominaga Kazuhiro Yatera Hiroaki Ida Tomoaki Hoshino |
| author_facet | Takuma Koga Masaki Okamoto Minoru Satoh Kiminori Fujimoto Yoshiaki Zaizen Tomonori Chikasue Akiko Sumi Shinjiro Kaieda Norikazu Matsuo Goushi Matama Takashi Nouno Masaki Tominaga Kazuhiro Yatera Hiroaki Ida Tomoaki Hoshino |
| author_sort | Takuma Koga |
| collection | DOAJ |
| description | Various autoantibodies are associated with clinical outcomes in patients with idiopathic interstitial pneumonias (IIPs). We retrospectively analyzed the association between autoantibodies and malignancies in IIP patients. Comprehensive analyses of autoantibodies were performed using immunoprecipitation and enzyme-linked immunosorbent assays in 193 consecutive IIP patients. Cancer-related factors were analyzed using logistic regression analysis. In total, 22 of 193 patients (11.4%) with IIP had malignant disease. In univariate analysis, positivity for any autoantibody (odds ratio (OR), 3.1; 95% confidence interval (CI), 1.2–7.7; <i>p</i> = 0.017) and antinuclear antibody titer ≥1:320 (OR, 3.4; CI, 1.2–9.8; <i>p</i> = 0.024) were significantly associated with malignancies. Positive anti-aminoacyl tRNA synthetase (ARS) (OR, 3.7; CI, 0.88–15.5; <i>p</i> = 0.074) and anti-Ro52 antibody (OR, 3.2; CI, 0.93–11.2; <i>p</i> = 0.065) tended to be associated with malignancies. In multivariate analysis, independent risk factors were male sex (OR, 3.7; CI, 1.0–13.5; <i>p</i> = 0.029) and positivity for any autoantibody (OR, 3.9; CI, 1.5–10.1; <i>p</i> = 0.004) in model 1, and male sex (OR, 3.9; CI, 1.0–15.3; <i>p</i> = 0.049), antinuclear antibody titer ≥1:320 (OR, 4.2; CI, 1.4–13.3; <i>p</i> = 0.013), and positivity for anti-ARS antibody (OR, 6.5; CI, 1.2–34.1; <i>p</i> = 0.026) in model 2. Positivity for any autoantibody, antinuclear and anti-ARS antibodies, and male sex were independent risk factors for malignancies in IIP patients. Testing autoantibodies in IIP patients might help the early diagnosis of malignancies. |
| first_indexed | 2024-03-09T20:39:06Z |
| format | Article |
| id | doaj.art-906cfb768a5f4414a7399ac800f68052 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:06Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-906cfb768a5f4414a7399ac800f680522023-11-23T23:03:33ZengMDPI AGBiomedicines2227-90592022-10-011010246910.3390/biomedicines10102469Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial PneumoniasTakuma Koga0Masaki Okamoto1Minoru Satoh2Kiminori Fujimoto3Yoshiaki Zaizen4Tomonori Chikasue5Akiko Sumi6Shinjiro Kaieda7Norikazu Matsuo8Goushi Matama9Takashi Nouno10Masaki Tominaga11Kazuhiro Yatera12Hiroaki Ida13Tomoaki Hoshino14Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDepartment of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Fukuoka 807-8555, JapanDepartment of Radiology, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDepartment of Radiology, Kurume University School of Medicine, Kurume 830-0011, JapanDepartment of Radiology, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka 807-8555, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, JapanVarious autoantibodies are associated with clinical outcomes in patients with idiopathic interstitial pneumonias (IIPs). We retrospectively analyzed the association between autoantibodies and malignancies in IIP patients. Comprehensive analyses of autoantibodies were performed using immunoprecipitation and enzyme-linked immunosorbent assays in 193 consecutive IIP patients. Cancer-related factors were analyzed using logistic regression analysis. In total, 22 of 193 patients (11.4%) with IIP had malignant disease. In univariate analysis, positivity for any autoantibody (odds ratio (OR), 3.1; 95% confidence interval (CI), 1.2–7.7; <i>p</i> = 0.017) and antinuclear antibody titer ≥1:320 (OR, 3.4; CI, 1.2–9.8; <i>p</i> = 0.024) were significantly associated with malignancies. Positive anti-aminoacyl tRNA synthetase (ARS) (OR, 3.7; CI, 0.88–15.5; <i>p</i> = 0.074) and anti-Ro52 antibody (OR, 3.2; CI, 0.93–11.2; <i>p</i> = 0.065) tended to be associated with malignancies. In multivariate analysis, independent risk factors were male sex (OR, 3.7; CI, 1.0–13.5; <i>p</i> = 0.029) and positivity for any autoantibody (OR, 3.9; CI, 1.5–10.1; <i>p</i> = 0.004) in model 1, and male sex (OR, 3.9; CI, 1.0–15.3; <i>p</i> = 0.049), antinuclear antibody titer ≥1:320 (OR, 4.2; CI, 1.4–13.3; <i>p</i> = 0.013), and positivity for anti-ARS antibody (OR, 6.5; CI, 1.2–34.1; <i>p</i> = 0.026) in model 2. Positivity for any autoantibody, antinuclear and anti-ARS antibodies, and male sex were independent risk factors for malignancies in IIP patients. Testing autoantibodies in IIP patients might help the early diagnosis of malignancies.https://www.mdpi.com/2227-9059/10/10/2469idiopathic interstitial pneumonialung cancerautoantibodynucleolar antinuclear antibody |
| spellingShingle | Takuma Koga Masaki Okamoto Minoru Satoh Kiminori Fujimoto Yoshiaki Zaizen Tomonori Chikasue Akiko Sumi Shinjiro Kaieda Norikazu Matsuo Goushi Matama Takashi Nouno Masaki Tominaga Kazuhiro Yatera Hiroaki Ida Tomoaki Hoshino Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias Biomedicines idiopathic interstitial pneumonia lung cancer autoantibody nucleolar antinuclear antibody |
| title | Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias |
| title_full | Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias |
| title_fullStr | Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias |
| title_full_unstemmed | Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias |
| title_short | Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias |
| title_sort | positive autoantibody is associated with malignancies in patients with idiopathic interstitial pneumonias |
| topic | idiopathic interstitial pneumonia lung cancer autoantibody nucleolar antinuclear antibody |
| url | https://www.mdpi.com/2227-9059/10/10/2469 |
| work_keys_str_mv | AT takumakoga positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT masakiokamoto positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT minorusatoh positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT kiminorifujimoto positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT yoshiakizaizen positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT tomonorichikasue positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT akikosumi positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT shinjirokaieda positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT norikazumatsuo positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT goushimatama positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT takashinouno positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT masakitominaga positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT kazuhiroyatera positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT hiroakiida positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias AT tomoakihoshino positiveautoantibodyisassociatedwithmalignanciesinpatientswithidiopathicinterstitialpneumonias |