From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease
Crohn’s disease (CD) is a debilitating, systemic inflammatory disorder with both gastrointestinal and extraintestinal manifestations. Its existence predates modern medicine, but its precise etiology remains incompletely understood. Most authorities suggest a multifactorial pathogenesis owing to a mi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-05-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756283X15576462 |
| _version_ | 1818448930380185600 |
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| author | Charles W. Randall John A. Vizuete Nicholas Martinez John J. Alvarez Karthik V. Garapati Mazyar Malakouti Carlo M. Taboada |
| author_facet | Charles W. Randall John A. Vizuete Nicholas Martinez John J. Alvarez Karthik V. Garapati Mazyar Malakouti Carlo M. Taboada |
| author_sort | Charles W. Randall |
| collection | DOAJ |
| description | Crohn’s disease (CD) is a debilitating, systemic inflammatory disorder with both gastrointestinal and extraintestinal manifestations. Its existence predates modern medicine, but its precise etiology remains incompletely understood. Most authorities suggest a multifactorial pathogenesis owing to a mixture of genetic disorders, immunologic dysregulation, microbiota disequilibrium and environmental influences. Of these factors, the overactive immunologic response seen in CD appears to be the most promising target of medical therapy. Biological agents comprise a relatively new class of drugs that can induce and maintain remission in moderate to severe CD, as well as in ulcerative colitis. This review will provide an overview of CD, its history, clinical features, pathophysiology, and treatment options focusing on current and future biological agents with an emphasis on drug development, dosage and administration. |
| first_indexed | 2024-12-14T20:27:20Z |
| format | Article |
| id | doaj.art-9071dcd42dfb49479f3434640bbe5bdf |
| institution | Directory Open Access Journal |
| issn | 1756-283X 1756-2848 |
| language | English |
| last_indexed | 2024-12-14T20:27:20Z |
| publishDate | 2015-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-9071dcd42dfb49479f3434640bbe5bdf2022-12-21T22:48:36ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-283X1756-28482015-05-01810.1177/1756283X15576462From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s diseaseCharles W. RandallJohn A. VizueteNicholas MartinezJohn J. AlvarezKarthik V. GarapatiMazyar MalakoutiCarlo M. TaboadaCrohn’s disease (CD) is a debilitating, systemic inflammatory disorder with both gastrointestinal and extraintestinal manifestations. Its existence predates modern medicine, but its precise etiology remains incompletely understood. Most authorities suggest a multifactorial pathogenesis owing to a mixture of genetic disorders, immunologic dysregulation, microbiota disequilibrium and environmental influences. Of these factors, the overactive immunologic response seen in CD appears to be the most promising target of medical therapy. Biological agents comprise a relatively new class of drugs that can induce and maintain remission in moderate to severe CD, as well as in ulcerative colitis. This review will provide an overview of CD, its history, clinical features, pathophysiology, and treatment options focusing on current and future biological agents with an emphasis on drug development, dosage and administration.https://doi.org/10.1177/1756283X15576462 |
| spellingShingle | Charles W. Randall John A. Vizuete Nicholas Martinez John J. Alvarez Karthik V. Garapati Mazyar Malakouti Carlo M. Taboada From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease Therapeutic Advances in Gastroenterology |
| title | From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease |
| title_full | From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease |
| title_fullStr | From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease |
| title_full_unstemmed | From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease |
| title_short | From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn’s disease |
| title_sort | from historical perspectives to modern therapy a review of current and future biological treatments for crohn s disease |
| url | https://doi.org/10.1177/1756283X15576462 |
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