Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression
Obesity is the most prevalent health problem in the Western world, with pathological body weight gain associated with numerous co-morbidities that can be the main cause of death. There are several factors that can contribute to the development of obesity, such as diet, sedentary lifestyle, and genet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/12/2273 |
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| author | Maria Vrânceanu Simona-Codruţa Hegheş Anamaria Cozma-Petruţ Roxana Banc Carmina Mariana Stroia Viorica Raischi Doina Miere Daniela-Saveta Popa Lorena Filip |
| author_facet | Maria Vrânceanu Simona-Codruţa Hegheş Anamaria Cozma-Petruţ Roxana Banc Carmina Mariana Stroia Viorica Raischi Doina Miere Daniela-Saveta Popa Lorena Filip |
| author_sort | Maria Vrânceanu |
| collection | DOAJ |
| description | Obesity is the most prevalent health problem in the Western world, with pathological body weight gain associated with numerous co-morbidities that can be the main cause of death. There are several factors that can contribute to the development of obesity, such as diet, sedentary lifestyle, and genetic make-up. Genetic predispositions play an important role in obesity, but genetic variations alone cannot fully explain the explosion of obesity, which is why studies have turned to epigenetics. The latest scientific evidence suggests that both genetics and environmental factors contribute to the rise in obesity. Certain variables, such as diet and exercise, have the ability to alter gene expression without affecting the DNA sequence, a phenomenon known as epigenetics. Epigenetic changes are reversible, and reversibility makes these changes attractive targets for therapeutic interventions. While anti-obesity drugs have been proposed to this end in recent decades, their numerous side effects make them not very attractive. On the other hand, the use of nutraceuticals for weight loss is increasing, and studies have shown that some of these products, such as resveratrol, curcumin, epigallocatechin-3-gallate, ginger, capsaicin, and caffeine, can alter gene expression, restoring the normal epigenetic profile and aiding weight loss. |
| first_indexed | 2024-03-11T02:02:12Z |
| format | Article |
| id | doaj.art-90721158f67b4aa99ee53090c1e3375d |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T02:02:12Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-90721158f67b4aa99ee53090c1e3375d2023-11-18T12:09:50ZengMDPI AGPlants2223-77472023-06-011212227310.3390/plants12122273Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene ExpressionMaria Vrânceanu0Simona-Codruţa Hegheş1Anamaria Cozma-Petruţ2Roxana Banc3Carmina Mariana Stroia4Viorica Raischi5Doina Miere6Daniela-Saveta Popa7Lorena Filip8Department of Toxicology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Drug Analysis, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Bromatology, Hygiene, Nutrition, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Bromatology, Hygiene, Nutrition, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Pharmacy, Oradea University, 1 Universităţii Street, 410087 Oradea, RomaniaLaboratory of Physiology of Stress, Adaptation and General Sanocreatology, Institute of Physiology and Sanocreatology, 1 Academiei Street, 2028 Chișinău, MoldovaDepartment of Bromatology, Hygiene, Nutrition, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Toxicology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Bromatology, Hygiene, Nutrition, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, RomaniaObesity is the most prevalent health problem in the Western world, with pathological body weight gain associated with numerous co-morbidities that can be the main cause of death. There are several factors that can contribute to the development of obesity, such as diet, sedentary lifestyle, and genetic make-up. Genetic predispositions play an important role in obesity, but genetic variations alone cannot fully explain the explosion of obesity, which is why studies have turned to epigenetics. The latest scientific evidence suggests that both genetics and environmental factors contribute to the rise in obesity. Certain variables, such as diet and exercise, have the ability to alter gene expression without affecting the DNA sequence, a phenomenon known as epigenetics. Epigenetic changes are reversible, and reversibility makes these changes attractive targets for therapeutic interventions. While anti-obesity drugs have been proposed to this end in recent decades, their numerous side effects make them not very attractive. On the other hand, the use of nutraceuticals for weight loss is increasing, and studies have shown that some of these products, such as resveratrol, curcumin, epigallocatechin-3-gallate, ginger, capsaicin, and caffeine, can alter gene expression, restoring the normal epigenetic profile and aiding weight loss.https://www.mdpi.com/2223-7747/12/12/2273obesitynutraceuticalsepigeneticsgene expressionweight loss |
| spellingShingle | Maria Vrânceanu Simona-Codruţa Hegheş Anamaria Cozma-Petruţ Roxana Banc Carmina Mariana Stroia Viorica Raischi Doina Miere Daniela-Saveta Popa Lorena Filip Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression Plants obesity nutraceuticals epigenetics gene expression weight loss |
| title | Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression |
| title_full | Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression |
| title_fullStr | Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression |
| title_full_unstemmed | Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression |
| title_short | Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression |
| title_sort | plant derived nutraceuticals involved in body weight control by modulating gene expression |
| topic | obesity nutraceuticals epigenetics gene expression weight loss |
| url | https://www.mdpi.com/2223-7747/12/12/2273 |
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