Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters
Butyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue i...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14191 |
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| author | Huan Yu Lunzhi Yuan Zhigang Yan Ming Zhou Jianghui Ye Kun Wu Wenjia Chen Rirong Chen Ningshao Xia Yi Guan Huachen Zhu |
| author_facet | Huan Yu Lunzhi Yuan Zhigang Yan Ming Zhou Jianghui Ye Kun Wu Wenjia Chen Rirong Chen Ningshao Xia Yi Guan Huachen Zhu |
| author_sort | Huan Yu |
| collection | DOAJ |
| description | Butyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue injury in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected golden hamsters supplemented with butyrate before and during the infection. Butyrate-treated hamsters showed augmentation of type I interferon (IFN) response and activation of endothelial cells without exaggerated inflammation. In addition, butyrate regulated redox homeostasis by enhancing the activity of superoxide dismutase (SOD) to inhibit excessive apoptotic cell death. Therefore, butyrate exhibited effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival. |
| first_indexed | 2024-03-10T22:39:18Z |
| format | Article |
| id | doaj.art-90723e06197f425393d2e29ae2a01da3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:18Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90723e06197f425393d2e29ae2a01da32023-11-19T11:09:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181419110.3390/ijms241814191Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden HamstersHuan Yu0Lunzhi Yuan1Zhigang Yan2Ming Zhou3Jianghui Ye4Kun Wu5Wenjia Chen6Rirong Chen7Ningshao Xia8Yi Guan9Huachen Zhu10Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, ChinaState Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen 361102, ChinaGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, ChinaState Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen 361102, ChinaGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, ChinaGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, ChinaState Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen 361102, ChinaGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, ChinaGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases (Key Laboratory of Ministry of Education), Joint Institute of Virology (Shantou University/The University of Hong Kong), Shantou University Medical College, Shantou 515063, ChinaButyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue injury in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected golden hamsters supplemented with butyrate before and during the infection. Butyrate-treated hamsters showed augmentation of type I interferon (IFN) response and activation of endothelial cells without exaggerated inflammation. In addition, butyrate regulated redox homeostasis by enhancing the activity of superoxide dismutase (SOD) to inhibit excessive apoptotic cell death. Therefore, butyrate exhibited effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival.https://www.mdpi.com/1422-0067/24/18/14191butyrateSARS-CoV-2golden hamstertype I IFNapoptosisoxidative stress |
| spellingShingle | Huan Yu Lunzhi Yuan Zhigang Yan Ming Zhou Jianghui Ye Kun Wu Wenjia Chen Rirong Chen Ningshao Xia Yi Guan Huachen Zhu Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters International Journal of Molecular Sciences butyrate SARS-CoV-2 golden hamster type I IFN apoptosis oxidative stress |
| title | Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters |
| title_full | Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters |
| title_fullStr | Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters |
| title_full_unstemmed | Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters |
| title_short | Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters |
| title_sort | butyrate protects against sars cov 2 induced tissue damage in golden hamsters |
| topic | butyrate SARS-CoV-2 golden hamster type I IFN apoptosis oxidative stress |
| url | https://www.mdpi.com/1422-0067/24/18/14191 |
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