Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases
Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diver...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01313/full |
| _version_ | 1818507959743807488 |
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| author | Li Wu Yu Tai Shanshan Hu Mei Zhang Rui Wang Weijie Zhou Juan Tao Yongsheng Han Qingtong Wang Wei Wei |
| author_facet | Li Wu Yu Tai Shanshan Hu Mei Zhang Rui Wang Weijie Zhou Juan Tao Yongsheng Han Qingtong Wang Wei Wei |
| author_sort | Li Wu |
| collection | DOAJ |
| description | Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of β2-AR, as well as different subtypes of Gα binding to β2-AR. In this review, we summarize the actions of β2-AR signaling in regulating the functions of immunocytes and in the pathogenesis of ADs, and the application of β2-AR agonists or antagonists in treating major types of ADs is also discussed. We suggest that restoring the immune balance via a soft regulation of the expression or activation of β2-AR is one of the promising therapeutic strategies for systematic ADs. |
| first_indexed | 2024-12-10T22:25:14Z |
| format | Article |
| id | doaj.art-90724ee3203f4ed69cd2b615f60279d4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T22:25:14Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-90724ee3203f4ed69cd2b615f60279d42022-12-22T01:31:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-11-01910.3389/fphar.2018.01313410985Bidirectional Role of β2-Adrenergic Receptor in Autoimmune DiseasesLi Wu0Yu Tai1Shanshan Hu2Mei Zhang3Rui Wang4Weijie Zhou5Juan Tao6Yongsheng Han7Qingtong Wang8Wei Wei9Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaDepartment of Emergency Medicine, The First Affiliated Hospital, University of Science and Technology of China, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaKey Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, ChinaDisorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of β2-AR, as well as different subtypes of Gα binding to β2-AR. In this review, we summarize the actions of β2-AR signaling in regulating the functions of immunocytes and in the pathogenesis of ADs, and the application of β2-AR agonists or antagonists in treating major types of ADs is also discussed. We suggest that restoring the immune balance via a soft regulation of the expression or activation of β2-AR is one of the promising therapeutic strategies for systematic ADs.https://www.frontiersin.org/article/10.3389/fphar.2018.01313/fullautoimmune diseasesβ2-adrenergic receptorsingle nucleotide polymorphismsimmune responsesoft regulation |
| spellingShingle | Li Wu Yu Tai Shanshan Hu Mei Zhang Rui Wang Weijie Zhou Juan Tao Yongsheng Han Qingtong Wang Wei Wei Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases Frontiers in Pharmacology autoimmune diseases β2-adrenergic receptor single nucleotide polymorphisms immune response soft regulation |
| title | Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases |
| title_full | Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases |
| title_fullStr | Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases |
| title_full_unstemmed | Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases |
| title_short | Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases |
| title_sort | bidirectional role of β2 adrenergic receptor in autoimmune diseases |
| topic | autoimmune diseases β2-adrenergic receptor single nucleotide polymorphisms immune response soft regulation |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01313/full |
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