New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports
Coronavirus disease 2019 (COVID-19) vaccine has effectively suppressed the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and alleviated its symptoms, but there are also many adverse events. Joint diseases caused by COVID-19 vaccine have been reported in many studies. Som...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/3/665 |
| _version_ | 1797608703112773632 |
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| author | Jie Liu Hui Wu Sheng-Li Xia |
| author_facet | Jie Liu Hui Wu Sheng-Li Xia |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) vaccine has effectively suppressed the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and alleviated its symptoms, but there are also many adverse events. Joint diseases caused by COVID-19 vaccine have been reported in many studies. Some are well-controlled arthritis patients who developed arthritis after COVID-19 vaccination, while others are new-onset joint pain and swelling problems after COVID-19 vaccination. The purpose of this systematic review is to examine the literature reports in existing databases and analyze the incidence of new-onset arthritis after COVID-19 vaccination. We included 31 eligible articles and described 45 patients, ranging in age from 17 to over 90, with more females than males. The majority (84.4%) of patients received the adenovirus vector vaccine (ChAdOx1) and the mRNA-based vaccine (BNT126b2 and mRNA-1273). Most (64.4%) patients developed joint-related symptoms after the first dose of vaccine, and 66.7% developed symptoms within the first week of vaccination. The joint symptoms involved were mainly joint swelling, joint pain, limited range of motion, and so on. A total of 71.1% of the patients involved multiple joints, both large and small; 28.9% of patients involved only a single joint. Some (33.3%) patients were confirmed by imaging, and the most common diagnoses were bursitis and synovitis. Two nonspecific inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were monitored in almost all cases, and all patients showed varying degrees of increase in these two markers. Most of the patients received the treatment of glucocorticoid drugs or nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical symptoms markedly improved in most patients, with 26.7% making a full recovery and no relapse after a few months of follow-up. To determine whether there is a causal relationship between COVID-19 vaccination and the triggering of arthritis, large-scale and well-controlled research studies are needed in the future to verify this relationship and to further study its pathogenesis in detail. Clinicians should raise awareness of this complication with a view to early diagnosis and appropriate treatment. |
| first_indexed | 2024-03-11T05:47:15Z |
| format | Article |
| id | doaj.art-907312fa5d014f53b531877c456fb930 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T05:47:15Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-907312fa5d014f53b531877c456fb9302023-11-17T14:19:17ZengMDPI AGVaccines2076-393X2023-03-0111366510.3390/vaccines11030665New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case ReportsJie Liu0Hui Wu1Sheng-Li Xia2Shanghai Jiao Tong University School of Medicine Library, No. 280, South Chongqing Road, Shanghai 200025, ChinaShanghai Jiao Tong University School of Medicine Library, No. 280, South Chongqing Road, Shanghai 200025, ChinaDepartment of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhoupu Zhouyuan Road, Pudong New Area, Shanghai 201318, ChinaCoronavirus disease 2019 (COVID-19) vaccine has effectively suppressed the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and alleviated its symptoms, but there are also many adverse events. Joint diseases caused by COVID-19 vaccine have been reported in many studies. Some are well-controlled arthritis patients who developed arthritis after COVID-19 vaccination, while others are new-onset joint pain and swelling problems after COVID-19 vaccination. The purpose of this systematic review is to examine the literature reports in existing databases and analyze the incidence of new-onset arthritis after COVID-19 vaccination. We included 31 eligible articles and described 45 patients, ranging in age from 17 to over 90, with more females than males. The majority (84.4%) of patients received the adenovirus vector vaccine (ChAdOx1) and the mRNA-based vaccine (BNT126b2 and mRNA-1273). Most (64.4%) patients developed joint-related symptoms after the first dose of vaccine, and 66.7% developed symptoms within the first week of vaccination. The joint symptoms involved were mainly joint swelling, joint pain, limited range of motion, and so on. A total of 71.1% of the patients involved multiple joints, both large and small; 28.9% of patients involved only a single joint. Some (33.3%) patients were confirmed by imaging, and the most common diagnoses were bursitis and synovitis. Two nonspecific inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were monitored in almost all cases, and all patients showed varying degrees of increase in these two markers. Most of the patients received the treatment of glucocorticoid drugs or nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical symptoms markedly improved in most patients, with 26.7% making a full recovery and no relapse after a few months of follow-up. To determine whether there is a causal relationship between COVID-19 vaccination and the triggering of arthritis, large-scale and well-controlled research studies are needed in the future to verify this relationship and to further study its pathogenesis in detail. Clinicians should raise awareness of this complication with a view to early diagnosis and appropriate treatment.https://www.mdpi.com/2076-393X/11/3/665coronavirus disease 2019 (COVID-19)arthritisadult-onset Still’s disease (AOSD)rheumatoid arthritis (RA)reactive arthritis (ReA)bursitis |
| spellingShingle | Jie Liu Hui Wu Sheng-Li Xia New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports Vaccines coronavirus disease 2019 (COVID-19) arthritis adult-onset Still’s disease (AOSD) rheumatoid arthritis (RA) reactive arthritis (ReA) bursitis |
| title | New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports |
| title_full | New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports |
| title_fullStr | New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports |
| title_full_unstemmed | New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports |
| title_short | New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports |
| title_sort | new onset arthritis following covid 19 vaccination a systematic review of case reports |
| topic | coronavirus disease 2019 (COVID-19) arthritis adult-onset Still’s disease (AOSD) rheumatoid arthritis (RA) reactive arthritis (ReA) bursitis |
| url | https://www.mdpi.com/2076-393X/11/3/665 |
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