Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder
Alcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine h...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2018.00009/full |
| _version_ | 1819112258435809280 |
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| author | Daniel Lindberg Lindsey Andres-Beck Yun-Fang Jia Seungwoo Kang Doo-Sup Choi Doo-Sup Choi Doo-Sup Choi |
| author_facet | Daniel Lindberg Lindsey Andres-Beck Yun-Fang Jia Seungwoo Kang Doo-Sup Choi Doo-Sup Choi Doo-Sup Choi |
| author_sort | Daniel Lindberg |
| collection | DOAJ |
| description | Alcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine have been demonstrated to alter the phase and function of the circadian clock and are reciprocally regulated by the clock itself. Importantly, chronic ethanol intake has been demonstrated to disrupt the molecular circadian clock and is associated with altered circadian patterns of activity and sleep. Moreover, ethanol has been demonstrated to disrupt purinergic signaling, while dysfunction of the purinergic system has been implicated in conditions of drug abuse such as AUD. In this review, we summarize our current knowledge regarding circadian disruption by ethanol, focusing on the reciprocal relationship that exists between oscillatory neurotransmission and the molecular circadian clock. In particular, we offer detailed explanations and hypotheses regarding the concerted regulation of purinergic signaling and circadian oscillations by neurons and astrocytes, and review the diverse mechanisms by which purinergic dysfuction may contribute to circadian disruption or alcohol abuse. Finally, we describe the mechanisms by which ethanol may disrupt or hijack endogenous circadian rhythms to induce the maladaptive behavioral patterns associated with AUD. |
| first_indexed | 2024-12-22T04:10:39Z |
| format | Article |
| id | doaj.art-9073641e1a344e858e66dc6d46a4c75f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T04:10:39Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-9073641e1a344e858e66dc6d46a4c75f2022-12-21T18:39:32ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-02-01910.3389/fphys.2018.00009332314Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use DisorderDaniel Lindberg0Lindsey Andres-Beck1Yun-Fang Jia2Seungwoo Kang3Doo-Sup Choi4Doo-Sup Choi5Doo-Sup Choi6Neurobiology of Disease, Mayo Clinic College of Medicine, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, United StatesNeurobiology of Disease, Mayo Clinic College of Medicine, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, United StatesDepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, United StatesAlcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine have been demonstrated to alter the phase and function of the circadian clock and are reciprocally regulated by the clock itself. Importantly, chronic ethanol intake has been demonstrated to disrupt the molecular circadian clock and is associated with altered circadian patterns of activity and sleep. Moreover, ethanol has been demonstrated to disrupt purinergic signaling, while dysfunction of the purinergic system has been implicated in conditions of drug abuse such as AUD. In this review, we summarize our current knowledge regarding circadian disruption by ethanol, focusing on the reciprocal relationship that exists between oscillatory neurotransmission and the molecular circadian clock. In particular, we offer detailed explanations and hypotheses regarding the concerted regulation of purinergic signaling and circadian oscillations by neurons and astrocytes, and review the diverse mechanisms by which purinergic dysfuction may contribute to circadian disruption or alcohol abuse. Finally, we describe the mechanisms by which ethanol may disrupt or hijack endogenous circadian rhythms to induce the maladaptive behavioral patterns associated with AUD.http://journal.frontiersin.org/article/10.3389/fphys.2018.00009/fullcircadianadenosineglutamateAUDethanolastrocyte |
| spellingShingle | Daniel Lindberg Lindsey Andres-Beck Yun-Fang Jia Seungwoo Kang Doo-Sup Choi Doo-Sup Choi Doo-Sup Choi Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder Frontiers in Physiology circadian adenosine glutamate AUD ethanol astrocyte |
| title | Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder |
| title_full | Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder |
| title_fullStr | Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder |
| title_full_unstemmed | Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder |
| title_short | Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder |
| title_sort | purinergic signaling in neuron astrocyte interactions circadian rhythms and alcohol use disorder |
| topic | circadian adenosine glutamate AUD ethanol astrocyte |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2018.00009/full |
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