mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans

mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans

Non-alcoholic steatohepatitis (NASH) can cause liver fibrosis and cirrhosis, with final progression to hepatocellular carcinoma (HCC) in some cases. Various factors have been suggested to be involved in the development of NASH. Considering the many possible contributing factors, we postulated that m...

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Bibliographic Details
Main Authors: Takahiro Okuno, Anna Kakehashi, Naomi Ishii, Masaki Fujioka, Min Gi, Hideki Wanibuchi
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
mTOR
NASH
metabolic syndrome
hepatocellular carcinoma
mouse models
Online Access:https://www.mdpi.com/2072-6694/10/12/465

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