Pharmacokinetics of fluorobenzyl polyethylene glycol conjugated tetraiodothyroacetic acid (NP751), a novel anticancer thyrointegrin αvβ3 antagonist

Pharmacokinetics of fluorobenzyl polyethylene glycol conjugated tetraiodothyroacetic acid (NP751), a novel anticancer thyrointegrin αvβ3 antagonist

We have recently reported on the development of fb-PMT (NP751), a conjugate of the thyroid hormone metabolite tetraiodothyroacetic acid (tetrac) and monodisperse polyethylene glycol 36. It exhibited high affinity for thyrointegrin αvβ3 receptor and potent anti-angiogenic and anticancer activity in v...

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Bibliographic Details
Main Authors:	Kazutoshi Fujioka, Bruce A. Hay, Kavitha Godugu, Shaker A. Mousa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Pharmacology
Subjects:	fb-PMT NP751 targeted cancer therapeutic tetrac thyrointegrin αvβ3 receptor LC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.902141/full

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