Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone
Bone matrix collagen, is one of the major contributors to bone quality. No studies have examined how bone quality affects the results of bone transplantation. Collagen cross-links (CCL) are the key factor in collagen properties. The purpose was to investigate the influences of CCL for both grafted b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/7/2/45 |
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| author | Suliman Mubarak Nagasawa Masako Farah A. Al-Omari Hamaya Keisuke Uoshima Katsumi |
| author_facet | Suliman Mubarak Nagasawa Masako Farah A. Al-Omari Hamaya Keisuke Uoshima Katsumi |
| author_sort | Suliman Mubarak |
| collection | DOAJ |
| description | Bone matrix collagen, is one of the major contributors to bone quality. No studies have examined how bone quality affects the results of bone transplantation. Collagen cross-links (CCL) are the key factor in collagen properties. The purpose was to investigate the influences of CCL for both grafted bone and recipient site bone on the success of bone augmentation. Four-week-old male Wister rats (<i>n</i> = 54) were divided into control and test groups. Control and test groups equally sub-divided into donors and recipients. An additional six rats were used to characterize bone at day zero. Test groups received 0.2% beta-aminoproperionitrile (BAPN) for 4 weeks as CCL inhibitor. Animals were further divided into donor and recipient groups. The transplanted bone chips integrated with host bone by 25% more in CCL-deficient animals compared to control. However, no difference in cortical thickness among all conditions. CCL-deficient transplanted bone did not show any extra signs of osteocyte apoptosis, while sclerostin expression was comparable to that in control. The host periosteum of CCL-deficient animals showed higher cellular activity, as well as higher bone quantity and osteoclast activity. Collagen cross-links deficiency in host bone might accelerate the incorporation of grafted bone. effect. Incorporation of the bone grafts appears to depend mainly on host condition rather than graft condition. |
| first_indexed | 2024-04-11T12:41:05Z |
| format | Article |
| id | doaj.art-9074e6f7659b4ef6b8e3ef10db4f0d47 |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-04-11T12:41:05Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-9074e6f7659b4ef6b8e3ef10db4f0d472022-12-22T04:23:30ZengMDPI AGDentistry Journal2304-67672019-05-01724510.3390/dj7020045dj7020045Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted BoneSuliman Mubarak0Nagasawa Masako1Farah A. Al-Omari2Hamaya Keisuke3Uoshima Katsumi4Division of Bio-Prosthodontics, Graduate School of Medical and Dental Sciences, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, JapanDivision of Bio-Prosthodontics, Graduate School of Medical and Dental Sciences, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, JapanDivision of Bio-Prosthodontics, Graduate School of Medical and Dental Sciences, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, JapanDivision of Bio-Prosthodontics, Graduate School of Medical and Dental Sciences, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, JapanDivision of Bio-Prosthodontics, Graduate School of Medical and Dental Sciences, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, JapanBone matrix collagen, is one of the major contributors to bone quality. No studies have examined how bone quality affects the results of bone transplantation. Collagen cross-links (CCL) are the key factor in collagen properties. The purpose was to investigate the influences of CCL for both grafted bone and recipient site bone on the success of bone augmentation. Four-week-old male Wister rats (<i>n</i> = 54) were divided into control and test groups. Control and test groups equally sub-divided into donors and recipients. An additional six rats were used to characterize bone at day zero. Test groups received 0.2% beta-aminoproperionitrile (BAPN) for 4 weeks as CCL inhibitor. Animals were further divided into donor and recipient groups. The transplanted bone chips integrated with host bone by 25% more in CCL-deficient animals compared to control. However, no difference in cortical thickness among all conditions. CCL-deficient transplanted bone did not show any extra signs of osteocyte apoptosis, while sclerostin expression was comparable to that in control. The host periosteum of CCL-deficient animals showed higher cellular activity, as well as higher bone quantity and osteoclast activity. Collagen cross-links deficiency in host bone might accelerate the incorporation of grafted bone. effect. Incorporation of the bone grafts appears to depend mainly on host condition rather than graft condition.https://www.mdpi.com/2304-6767/7/2/45collagen cross-linksbone qualityhost bonegraftHealing |
| spellingShingle | Suliman Mubarak Nagasawa Masako Farah A. Al-Omari Hamaya Keisuke Uoshima Katsumi Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone Dentistry Journal collagen cross-links bone quality host bone graft Healing |
| title | Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone |
| title_full | Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone |
| title_fullStr | Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone |
| title_full_unstemmed | Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone |
| title_short | Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone |
| title_sort | effect of collagen cross link deficiency on incorporation of grafted bone |
| topic | collagen cross-links bone quality host bone graft Healing |
| url | https://www.mdpi.com/2304-6767/7/2/45 |
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