Mouse hygiene status–A tale of two environments for mast cells and allergy
Animal models, including those employing the use of house mice (Mus musculus), are crucial in elucidating mechanisms in human pathophysiology. However, it is evident that the impreciseness of using laboratory mice maintained in super-hygienic barrier facilities to mirror relevant aspects of human ph...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893023000849 |
| _version_ | 1827390397794484224 |
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| author | Yu-Wen Yeh Zou Xiang |
| author_facet | Yu-Wen Yeh Zou Xiang |
| author_sort | Yu-Wen Yeh |
| collection | DOAJ |
| description | Animal models, including those employing the use of house mice (Mus musculus), are crucial in elucidating mechanisms in human pathophysiology. However, it is evident that the impreciseness of using laboratory mice maintained in super-hygienic barrier facilities to mirror relevant aspects of human physiology and pathology exists, which is a major limitation in translating mouse findings to inferring human medicine. Interestingly, free-living wild mice are found to be substantially different from laboratory-bred, specific pathogen-free mice with respect to various immune system compartments. Wild mice have an immune system that better reflects human immunity. In this review article, we discuss recent experimental findings that address the so-called “wild immunology”, which reveals the contrasting immune features between laboratory-raised mice and their wild companions as well as laboratory mice that have been exposed to a natural rodent habitat. A particular focus will be given to the development of pulmonary mast cells and its possible impact on the use of “naturalized” or “rewilded” laboratory mice as experimental asthma models. |
| first_indexed | 2024-03-08T16:52:06Z |
| format | Article |
| id | doaj.art-9077a204eb9d42aea3c091d5de4215bb |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-03-08T16:52:06Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-9077a204eb9d42aea3c091d5de4215bb2024-01-05T04:23:46ZengElsevierAllergology International1323-89302024-01-017315864Mouse hygiene status–A tale of two environments for mast cells and allergyYu-Wen Yeh0Zou Xiang1Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, ChinaCorresponding author.; Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, ChinaAnimal models, including those employing the use of house mice (Mus musculus), are crucial in elucidating mechanisms in human pathophysiology. However, it is evident that the impreciseness of using laboratory mice maintained in super-hygienic barrier facilities to mirror relevant aspects of human physiology and pathology exists, which is a major limitation in translating mouse findings to inferring human medicine. Interestingly, free-living wild mice are found to be substantially different from laboratory-bred, specific pathogen-free mice with respect to various immune system compartments. Wild mice have an immune system that better reflects human immunity. In this review article, we discuss recent experimental findings that address the so-called “wild immunology”, which reveals the contrasting immune features between laboratory-raised mice and their wild companions as well as laboratory mice that have been exposed to a natural rodent habitat. A particular focus will be given to the development of pulmonary mast cells and its possible impact on the use of “naturalized” or “rewilded” laboratory mice as experimental asthma models.http://www.sciencedirect.com/science/article/pii/S1323893023000849AsthmaGut microbiotaMast cellMouse naturalizationWild mouse |
| spellingShingle | Yu-Wen Yeh Zou Xiang Mouse hygiene status–A tale of two environments for mast cells and allergy Allergology International Asthma Gut microbiota Mast cell Mouse naturalization Wild mouse |
| title | Mouse hygiene status–A tale of two environments for mast cells and allergy |
| title_full | Mouse hygiene status–A tale of two environments for mast cells and allergy |
| title_fullStr | Mouse hygiene status–A tale of two environments for mast cells and allergy |
| title_full_unstemmed | Mouse hygiene status–A tale of two environments for mast cells and allergy |
| title_short | Mouse hygiene status–A tale of two environments for mast cells and allergy |
| title_sort | mouse hygiene status a tale of two environments for mast cells and allergy |
| topic | Asthma Gut microbiota Mast cell Mouse naturalization Wild mouse |
| url | http://www.sciencedirect.com/science/article/pii/S1323893023000849 |
| work_keys_str_mv | AT yuwenyeh mousehygienestatusataleoftwoenvironmentsformastcellsandallergy AT zouxiang mousehygienestatusataleoftwoenvironmentsformastcellsandallergy |