Malaria liver stage susceptibility locus identified on mouse chromosome 17 by congenic mapping.

Host genetic variants are known to confer resistance to Plasmodium blood stage infection and to control malaria severity both in humans and mice. This work describes the genetic mapping of a locus for resistance to liver stage parasite in the mouse. First, we show that decreased susceptibility to th...

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Bibliographic Details
Main Authors: Lígia Antunes Gonçalves, Paulo Almeida, Maria Manuel Mota, Carlos Penha-Gonçalves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2267218?pdf=render