The impact of vaccination to clinical severity and mortality of COVID-19 patients
Background: SARS-CoV-2 was discovered in December 2019 and later become global pandemic. Preliminary studies stated that broad vaccine coverage will suppress mortality and incidence of COVID-19. Therefore, we conduct a cross-sectional study to assess the efficacy of COVID-19 vaccination. Materials a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Bali Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2023;volume=7;issue=1;spage=3;epage=7;aulast=Purnamasidhi |
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| author | Cokorda Agung Wahyu Purnamasidhi Pande Putu Januraga Ni Made Dewi Dian Sukmawati Anak Agung Ayu Yuli Gayatri I Made Susila Utama I Ketut Agus Somia Ketut Tuti Parwati Merati Richard Christian Suteja Giovanca Verentzia Purnama |
| author_facet | Cokorda Agung Wahyu Purnamasidhi Pande Putu Januraga Ni Made Dewi Dian Sukmawati Anak Agung Ayu Yuli Gayatri I Made Susila Utama I Ketut Agus Somia Ketut Tuti Parwati Merati Richard Christian Suteja Giovanca Verentzia Purnama |
| author_sort | Cokorda Agung Wahyu Purnamasidhi |
| collection | DOAJ |
| description | Background: SARS-CoV-2 was discovered in December 2019 and later become global pandemic. Preliminary studies stated that broad vaccine coverage will suppress mortality and incidence of COVID-19. Therefore, we conduct a cross-sectional study to assess the efficacy of COVID-19 vaccination. Materials and Methods: We collected secondary data from electronic medical records of 343 COVID-19 positive patients confirmed via reverse transcription polymerase chain reaction from July 2021 to December 2021. We analyzed epidemiologic data, vaccination history, baseline symptoms, comorbidity, baseline vital signs, and outcome using hypothesis testing χ2 and logistic regression. Results: Sex had an χ2 of 9.34 (P < 0.001) while type of vaccine had an χ2 of 1.49 (P = 0.22) to clinical severity. Age, pulse rate, respiration rate, body temperature, and Glasgow coma scale were found to be significant risk factors to clinical severity. Number of vaccines previously received was found to be a protective factor to clinical severity (odds ratio (OR) = 0.49, 95% CI = 0.32–0.74, P < 0.001). We also found that sex (χ2 = 10.42, P < 0.001) was a predictor to discharge condition. Moreover, age was also found to be a significant predictor (OR = 1.03, 95% CI = 1.03–1.05, P < 0.001), as well as number of symptoms (OR = 0.66, P < 0.001), comorbidities (OR = 1.64, P < 0.001), pulse rate (OR = 1.04, P < 0.001), respiration rate (OR = 1.17, P < 0.001), and Glasgow coma scale (OR = 0.72, P = 0.03). Conclusion: Age, sex, number of vaccines received, number of symptoms, number of comorbidities, pulse rate, and respiration rate were significant predictors of clinical severity and outcome in COVID-19 patients. In addition, body temperature was also a predictor for clinical severity, while Glasgow coma scale was a predictor for outcome. |
| first_indexed | 2024-04-09T23:29:51Z |
| format | Article |
| id | doaj.art-907b416b3bc5467f8b754454f28f58c2 |
| institution | Directory Open Access Journal |
| issn | 2549-2276 |
| language | English |
| last_indexed | 2024-04-09T23:29:51Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Bali Journal of Anesthesiology |
| spelling | doaj.art-907b416b3bc5467f8b754454f28f58c22023-03-21T07:28:15ZengWolters Kluwer Medknow PublicationsBali Journal of Anesthesiology2549-22762023-01-01713710.4103/bjoa.bjoa_268_22The impact of vaccination to clinical severity and mortality of COVID-19 patientsCokorda Agung Wahyu PurnamasidhiPande Putu JanuragaNi Made Dewi Dian SukmawatiAnak Agung Ayu Yuli GayatriI Made Susila UtamaI Ketut Agus SomiaKetut Tuti Parwati MeratiRichard Christian SutejaGiovanca Verentzia PurnamaBackground: SARS-CoV-2 was discovered in December 2019 and later become global pandemic. Preliminary studies stated that broad vaccine coverage will suppress mortality and incidence of COVID-19. Therefore, we conduct a cross-sectional study to assess the efficacy of COVID-19 vaccination. Materials and Methods: We collected secondary data from electronic medical records of 343 COVID-19 positive patients confirmed via reverse transcription polymerase chain reaction from July 2021 to December 2021. We analyzed epidemiologic data, vaccination history, baseline symptoms, comorbidity, baseline vital signs, and outcome using hypothesis testing χ2 and logistic regression. Results: Sex had an χ2 of 9.34 (P < 0.001) while type of vaccine had an χ2 of 1.49 (P = 0.22) to clinical severity. Age, pulse rate, respiration rate, body temperature, and Glasgow coma scale were found to be significant risk factors to clinical severity. Number of vaccines previously received was found to be a protective factor to clinical severity (odds ratio (OR) = 0.49, 95% CI = 0.32–0.74, P < 0.001). We also found that sex (χ2 = 10.42, P < 0.001) was a predictor to discharge condition. Moreover, age was also found to be a significant predictor (OR = 1.03, 95% CI = 1.03–1.05, P < 0.001), as well as number of symptoms (OR = 0.66, P < 0.001), comorbidities (OR = 1.64, P < 0.001), pulse rate (OR = 1.04, P < 0.001), respiration rate (OR = 1.17, P < 0.001), and Glasgow coma scale (OR = 0.72, P = 0.03). Conclusion: Age, sex, number of vaccines received, number of symptoms, number of comorbidities, pulse rate, and respiration rate were significant predictors of clinical severity and outcome in COVID-19 patients. In addition, body temperature was also a predictor for clinical severity, while Glasgow coma scale was a predictor for outcome.http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2023;volume=7;issue=1;spage=3;epage=7;aulast=Purnamasidhiclinical severitycovid-19mortalityprediction modelvaccination |
| spellingShingle | Cokorda Agung Wahyu Purnamasidhi Pande Putu Januraga Ni Made Dewi Dian Sukmawati Anak Agung Ayu Yuli Gayatri I Made Susila Utama I Ketut Agus Somia Ketut Tuti Parwati Merati Richard Christian Suteja Giovanca Verentzia Purnama The impact of vaccination to clinical severity and mortality of COVID-19 patients Bali Journal of Anesthesiology clinical severity covid-19 mortality prediction model vaccination |
| title | The impact of vaccination to clinical severity and mortality of COVID-19 patients |
| title_full | The impact of vaccination to clinical severity and mortality of COVID-19 patients |
| title_fullStr | The impact of vaccination to clinical severity and mortality of COVID-19 patients |
| title_full_unstemmed | The impact of vaccination to clinical severity and mortality of COVID-19 patients |
| title_short | The impact of vaccination to clinical severity and mortality of COVID-19 patients |
| title_sort | impact of vaccination to clinical severity and mortality of covid 19 patients |
| topic | clinical severity covid-19 mortality prediction model vaccination |
| url | http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2023;volume=7;issue=1;spage=3;epage=7;aulast=Purnamasidhi |
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