A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia
Background: Schizophrenia is characterized by self-disturbances, including impaired self-evaluation abilities and source monitoring. The cortical midline structures (e.g., medial prefrontal cortex, anterior and posterior cingulate cortex, and precuneus) and the temporoparietal junction are known to...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-09-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00990/full |
| _version_ | 1818275645265805312 |
|---|---|
| author | Stéphane Potvin Stéphane Potvin Lydia Gamache Ovidiu Lungu Ovidiu Lungu |
| author_facet | Stéphane Potvin Stéphane Potvin Lydia Gamache Ovidiu Lungu Ovidiu Lungu |
| author_sort | Stéphane Potvin |
| collection | DOAJ |
| description | Background: Schizophrenia is characterized by self-disturbances, including impaired self-evaluation abilities and source monitoring. The cortical midline structures (e.g., medial prefrontal cortex, anterior and posterior cingulate cortex, and precuneus) and the temporoparietal junction are known to play a key role in self-related processing. In theory, self-disturbances in schizophrenia may arise from impaired activity in these regions. We performed a functional neuroimaging meta-analysis to verify this hypothesis.Methods: A literature search was performed with PubMed and Google Scholar to identify functional neuroimaging studies examining the neural correlates of self-processing in schizophrenia, using self-other or source monitoring paradigms. Fourteen studies were retrieved, involving 245 patients and 201 controls. Using peak coordinates to recreate an effect-size map of contrast results, a standard random-effects variance weighted meta-analysis for each voxel was performed with the Seed-based d Mapping software.Results: During self-processing, decreased activations were observed in schizophrenia patients relative to controls in the bilateral thalamus and the left dorsal anterior cingulate cortex (dACC) and dorso-medial prefrontal cortex. Importantly, results were homogeneous across studies, and no publication bias was observed. Sensitivity analyses revealed that results were replicable in 93–100% of studies.Conclusion: The current results partially support the hypothesized impaired activity of cortical midline brain regions in schizophrenia during self-processing. Decreased activations were observed in the dACC and dorsomedial prefrontal cortex, which are involved in cognitive control and/or salience attribution, as well as decision-making, respectively. These alterations may compromise patients' ability to direct their attention toward themselves and/or others and to make the decision whether a certain trait applies to one's self or to someone else. In addition, decreased activations were observed in the thalamus, which is not a core region of the default-mode network, and is involved in information integration. These thalamic alterations may compromise self-coherence in schizophrenia. |
| first_indexed | 2024-12-12T22:33:03Z |
| format | Article |
| id | doaj.art-907ba2ba6271462a9624ac74bef72757 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T22:33:03Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-907ba2ba6271462a9624ac74bef727572022-12-22T00:09:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-09-011010.3389/fneur.2019.00990463383A Functional Neuroimaging Meta-Analysis of Self-Related Processing in SchizophreniaStéphane Potvin0Stéphane Potvin1Lydia Gamache2Ovidiu Lungu3Ovidiu Lungu4Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, QC, CanadaDepartment of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, QC, CanadaDepartment of Psychology, University of Montreal, Montreal, QC, CanadaDepartment of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, QC, CanadaCentre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC, CanadaBackground: Schizophrenia is characterized by self-disturbances, including impaired self-evaluation abilities and source monitoring. The cortical midline structures (e.g., medial prefrontal cortex, anterior and posterior cingulate cortex, and precuneus) and the temporoparietal junction are known to play a key role in self-related processing. In theory, self-disturbances in schizophrenia may arise from impaired activity in these regions. We performed a functional neuroimaging meta-analysis to verify this hypothesis.Methods: A literature search was performed with PubMed and Google Scholar to identify functional neuroimaging studies examining the neural correlates of self-processing in schizophrenia, using self-other or source monitoring paradigms. Fourteen studies were retrieved, involving 245 patients and 201 controls. Using peak coordinates to recreate an effect-size map of contrast results, a standard random-effects variance weighted meta-analysis for each voxel was performed with the Seed-based d Mapping software.Results: During self-processing, decreased activations were observed in schizophrenia patients relative to controls in the bilateral thalamus and the left dorsal anterior cingulate cortex (dACC) and dorso-medial prefrontal cortex. Importantly, results were homogeneous across studies, and no publication bias was observed. Sensitivity analyses revealed that results were replicable in 93–100% of studies.Conclusion: The current results partially support the hypothesized impaired activity of cortical midline brain regions in schizophrenia during self-processing. Decreased activations were observed in the dACC and dorsomedial prefrontal cortex, which are involved in cognitive control and/or salience attribution, as well as decision-making, respectively. These alterations may compromise patients' ability to direct their attention toward themselves and/or others and to make the decision whether a certain trait applies to one's self or to someone else. In addition, decreased activations were observed in the thalamus, which is not a core region of the default-mode network, and is involved in information integration. These thalamic alterations may compromise self-coherence in schizophrenia.https://www.frontiersin.org/article/10.3389/fneur.2019.00990/fullschizophreniaself-processingfMRImeta-analysisanterior cingulate cortexprefrontal cortex and thalamus |
| spellingShingle | Stéphane Potvin Stéphane Potvin Lydia Gamache Ovidiu Lungu Ovidiu Lungu A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia Frontiers in Neurology schizophrenia self-processing fMRI meta-analysis anterior cingulate cortex prefrontal cortex and thalamus |
| title | A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia |
| title_full | A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia |
| title_fullStr | A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia |
| title_full_unstemmed | A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia |
| title_short | A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia |
| title_sort | functional neuroimaging meta analysis of self related processing in schizophrenia |
| topic | schizophrenia self-processing fMRI meta-analysis anterior cingulate cortex prefrontal cortex and thalamus |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00990/full |
| work_keys_str_mv | AT stephanepotvin afunctionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT stephanepotvin afunctionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT lydiagamache afunctionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT ovidiulungu afunctionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT ovidiulungu afunctionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT stephanepotvin functionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT stephanepotvin functionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT lydiagamache functionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT ovidiulungu functionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia AT ovidiulungu functionalneuroimagingmetaanalysisofselfrelatedprocessinginschizophrenia |