Ganoderma triterpenes Protect Against Hyperhomocysteinemia Induced Endothelial-Mesenchymal Transition via TGF-β Signaling Inhibition

Ganoderma triterpenes Protect Against Hyperhomocysteinemia Induced Endothelial-Mesenchymal Transition via TGF-β Signaling Inhibition

Endothelial dysfunction is one of the most important pathological status in hyperhomocysteinemia (HHcy) related cardiovascular diseases. Whereas, the underlying mechanisms have not been fully elucidated yet, concomitant with the absence of effective treatment. The purpose of this study was to explor...

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Bibliographic Details
Main Authors: Jinzhao He, Yi Sun, Yingli Jia, Xiaoqiang Geng, Ruoyun Chen, Hong Zhou, Baoxue Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
homocysteine
endothelial cells
endothelial-mesenchymal transition
TGF-β
oxidative stress
Ganoderma triterpenes
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00192/full

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