Non-uniform in vivo Expansion of Epstein-Barr Virus-Specific T-Cells Following Donor Lymphocyte Infusion for Post-transplant Lymphoproliferative Disease

Non-uniform in vivo Expansion of Epstein-Barr Virus-Specific T-Cells Following Donor Lymphocyte Infusion for Post-transplant Lymphoproliferative Disease

Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) is a life-threatening complication of T-lymphocyte deplete allogeneic hematopoietic stem cell transplantation (allo-HSCT). For patients with PTLD refractory to Rituximab, donor lymphocyte infusion (DLI) is establi...

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Bibliographic Details
Main Authors: David M. Burns, Gordon B. Ryan, Caroline M. Harvey, Eszter Nagy, Simon Hughes, Paul G. Murray, Nigel H. Russell, Christopher P. Fox, Heather M. Long
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
post-transplant lymphoproliferative disease
PTLD
Epstein-Barr virus
adoptive T-cell therapy
donor lymphocyte infusion
T-cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02489/full

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