The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons
In 1960, Gustav Born was appointed to head the Department of Pharmacology at the Royal College of Surgeons in London. The next 13 years would prove to be the most productive in his scientific career and the most important in the development of the Department into an internationally respected resea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1513252 |
| _version_ | 1797684279166107648 |
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| author | Anne Atherton Nicola Begent Geoffrey J. Blackwell Y. S. Bakhle |
| author_facet | Anne Atherton Nicola Begent Geoffrey J. Blackwell Y. S. Bakhle |
| author_sort | Anne Atherton |
| collection | DOAJ |
| description | In 1960, Gustav Born was appointed to head the Department of Pharmacology at the Royal College of Surgeons in London. The next 13 years would prove to be the most productive in his scientific career and the most important in the development of the Department into an internationally respected research center. The advances in platelet biology were made possible by the evolution of the platelet aggregometer, brilliantly conceived and developed by Born and his team, into a robust and reliable scientific instrument, with which they, quite literally, revolutionized the study of platelet function. For the first time, the actions of agonists and antagonists could be quantified pharmacologically, and the biochemistry of aggregation analyzed, identifying two systems, cyclic nucleotides and phospholipid metabolism, as crucial to the understanding of the pathophysiology of human platelets. Recognizing the critical importance of the interplay between platelets, leucocytes and the vascular endothelium, in the formation and in the rupture of atheromatous plaques, his group also investigated aggregation in the microvasculature in vivo. Born’s never-ending flow of ideas and enthusiasm for their exploration created an atmosphere of discovery in his group that matched that of his colleague, John Vane. It was a collaboration between these two teams that elucidated the mechanism of action of the non-steroidal anti-inflammatory drugs (NSAIDs) and established the prophylactic use of aspirin as an anti-thrombotic therapy – indeed, two of the most significant pharmacological discoveries of the twentieth century. |
| first_indexed | 2024-03-12T00:27:10Z |
| format | Article |
| id | doaj.art-907d78d1c0ac4ff6a73b9566354774ca |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:10Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-907d78d1c0ac4ff6a73b9566354774ca2023-09-15T10:32:00ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-01-013013610.1080/09537104.2018.15132521513252The platelet aggregometer and beyond: Gustav Born at the Royal College of SurgeonsAnne Atherton0Nicola Begent1Geoffrey J. Blackwell2Y. S. Bakhle3Independent ScholarIndependent ScholarIndependent ScholarImperial CollegeIn 1960, Gustav Born was appointed to head the Department of Pharmacology at the Royal College of Surgeons in London. The next 13 years would prove to be the most productive in his scientific career and the most important in the development of the Department into an internationally respected research center. The advances in platelet biology were made possible by the evolution of the platelet aggregometer, brilliantly conceived and developed by Born and his team, into a robust and reliable scientific instrument, with which they, quite literally, revolutionized the study of platelet function. For the first time, the actions of agonists and antagonists could be quantified pharmacologically, and the biochemistry of aggregation analyzed, identifying two systems, cyclic nucleotides and phospholipid metabolism, as crucial to the understanding of the pathophysiology of human platelets. Recognizing the critical importance of the interplay between platelets, leucocytes and the vascular endothelium, in the formation and in the rupture of atheromatous plaques, his group also investigated aggregation in the microvasculature in vivo. Born’s never-ending flow of ideas and enthusiasm for their exploration created an atmosphere of discovery in his group that matched that of his colleague, John Vane. It was a collaboration between these two teams that elucidated the mechanism of action of the non-steroidal anti-inflammatory drugs (NSAIDs) and established the prophylactic use of aspirin as an anti-thrombotic therapy – indeed, two of the most significant pharmacological discoveries of the twentieth century.http://dx.doi.org/10.1080/09537104.2018.1513252gustav bornplatelet aggregometer |
| spellingShingle | Anne Atherton Nicola Begent Geoffrey J. Blackwell Y. S. Bakhle The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons Platelets gustav born platelet aggregometer |
| title | The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons |
| title_full | The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons |
| title_fullStr | The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons |
| title_full_unstemmed | The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons |
| title_short | The platelet aggregometer and beyond: Gustav Born at the Royal College of Surgeons |
| title_sort | platelet aggregometer and beyond gustav born at the royal college of surgeons |
| topic | gustav born platelet aggregometer |
| url | http://dx.doi.org/10.1080/09537104.2018.1513252 |
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