Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk
Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structura...
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.031915 |
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| author | Aniqa B. Alam Estefania Toledo‐Atucha Dora Romaguera Angel M. Alonso‐Gómez Miguel A. Martínez‐Gonzalez Lucas Tojal‐Sierra Marta Noris Mora Caterina Mas‐Llado Linzi Li Ines Gonzalez‐Casanova Jordi Salas‐Salvadó Montserrat Fitó Alvaro Alonso |
| author_facet | Aniqa B. Alam Estefania Toledo‐Atucha Dora Romaguera Angel M. Alonso‐Gómez Miguel A. Martínez‐Gonzalez Lucas Tojal‐Sierra Marta Noris Mora Caterina Mas‐Llado Linzi Li Ines Gonzalez‐Casanova Jordi Salas‐Salvadó Montserrat Fitó Alvaro Alonso |
| author_sort | Aniqa B. Alam |
| collection | DOAJ |
| description | Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. Methods and Results We studied 503 participants from the PREDIMED‐Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy‐reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow‐up. Cross‐sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18–1.11]) and lower left atrial reservoir and contractile strain (−0.44% [95% CI, −0.87 to −0.01]; and −0.44% [95% CI, −0.75 to −0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow‐up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17–1.26]). Conclusions In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function. Registration URL: http://www.controlled‐trials.com; Unique identifier: ISRCTN89898870. |
| first_indexed | 2024-04-24T15:09:45Z |
| format | Article |
| id | doaj.art-907dfde640d64caa931aaeaf8e7282d5 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-24T15:09:45Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-907dfde640d64caa931aaeaf8e7282d52024-04-02T11:49:51ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-04-0113710.1161/JAHA.123.031915Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular RiskAniqa B. Alam0Estefania Toledo‐Atucha1Dora Romaguera2Angel M. Alonso‐Gómez3Miguel A. Martínez‐Gonzalez4Lucas Tojal‐Sierra5Marta Noris Mora6Caterina Mas‐Llado7Linzi Li8Ines Gonzalez‐Casanova9Jordi Salas‐Salvadó10Montserrat Fitó11Alvaro Alonso12Department of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USACIBER Consortium, M.P. Physiopathology of Obesity and Nutrition (CIBERObn) Carlos III Health Institute (ISCIII) Madrid SpainCIBER Consortium, M.P. Physiopathology of Obesity and Nutrition (CIBERObn) Carlos III Health Institute (ISCIII) Madrid SpainCIBER Consortium, M.P. Physiopathology of Obesity and Nutrition (CIBERObn) Carlos III Health Institute (ISCIII) Madrid SpainCIBER Consortium, M.P. Physiopathology of Obesity and Nutrition (CIBERObn) Carlos III Health Institute (ISCIII) Madrid SpainNavarra’s Health Research Institute (IdiSNA), Navarra Institute for Health Research Pamplona SpainHealth Research Institute of the Balearic Islands (IdISBa) Palma de Mallorca SpainHealth Research Institute of the Balearic Islands (IdISBa) Palma de Mallorca SpainDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USADepartment of Applied Health Science Indiana University‐Bloomington, School of Public Health Bloomington Indiana USACIBER Consortium, M.P. Physiopathology of Obesity and Nutrition (CIBERObn) Carlos III Health Institute (ISCIII) Madrid SpainCIBER Consortium, M.P. Physiopathology of Obesity and Nutrition (CIBERObn) Carlos III Health Institute (ISCIII) Madrid SpainDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USABackground Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. Methods and Results We studied 503 participants from the PREDIMED‐Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy‐reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow‐up. Cross‐sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18–1.11]) and lower left atrial reservoir and contractile strain (−0.44% [95% CI, −0.87 to −0.01]; and −0.44% [95% CI, −0.75 to −0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow‐up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17–1.26]). Conclusions In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function. Registration URL: http://www.controlled‐trials.com; Unique identifier: ISRCTN89898870.https://www.ahajournals.org/doi/10.1161/JAHA.123.031915alcohol consumptionatrial fibrillationatrial structure and function |
| spellingShingle | Aniqa B. Alam Estefania Toledo‐Atucha Dora Romaguera Angel M. Alonso‐Gómez Miguel A. Martínez‐Gonzalez Lucas Tojal‐Sierra Marta Noris Mora Caterina Mas‐Llado Linzi Li Ines Gonzalez‐Casanova Jordi Salas‐Salvadó Montserrat Fitó Alvaro Alonso Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease alcohol consumption atrial fibrillation atrial structure and function |
| title | Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk |
| title_full | Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk |
| title_fullStr | Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk |
| title_full_unstemmed | Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk |
| title_short | Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk |
| title_sort | associations of alcohol consumption with left atrial morphology and function in a population at high cardiovascular risk |
| topic | alcohol consumption atrial fibrillation atrial structure and function |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.031915 |
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