Turtle interacts with borderless in regulating glial extension and axon ensheathment
Abstract Proper recognition between axons and glial processes is required for the establishment of axon ensheathment in the developing nervous system. Recent studies have begun to reveal molecular events underlying developmental control of axon-glia recognition. In our previous work, we showed that...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-05-01
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| Series: | Molecular Brain |
| Online Access: | http://link.springer.com/article/10.1186/s13041-017-0299-6 |
| _version_ | 1818008813447413760 |
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| author | Yixu Chen Scott Cameron Wen-Tzu Chang Yong Rao |
| author_facet | Yixu Chen Scott Cameron Wen-Tzu Chang Yong Rao |
| author_sort | Yixu Chen |
| collection | DOAJ |
| description | Abstract Proper recognition between axons and glial processes is required for the establishment of axon ensheathment in the developing nervous system. Recent studies have begun to reveal molecular events underlying developmental control of axon-glia recognition. In our previous work, we showed that the transmembrane protein Borderless (Bdl) is specifically expressed in wrapping glia (WG), and is required for the extension of glial processes and the ensheathment of photoreceptor axons in the developing Drosophila visual system. The exact mechanism by which Bdl mediates axon-glia recognition, however, remains unknown. Here, we present evidence showing that Bdl interacts with the Ig transmembrane protein Turtle (Tutl). Tutl is specifically expressed in photoreceptor axons. Loss of tutl in photoreceptors, like loss of bdl in WG, disrupts glial extension and axon ensheatment. Epistasis analysis shows that Tutl interacts genetically with Bdl. Tutl interacts with Bdl in trans in cultured cells. We propose that Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment. |
| first_indexed | 2024-04-14T05:34:54Z |
| format | Article |
| id | doaj.art-907e6dd60308463085deff1e729c08c4 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-04-14T05:34:54Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-907e6dd60308463085deff1e729c08c42022-12-22T02:09:42ZengBMCMolecular Brain1756-66062017-05-0110111110.1186/s13041-017-0299-6Turtle interacts with borderless in regulating glial extension and axon ensheathmentYixu Chen0Scott Cameron1Wen-Tzu Chang2Yong Rao3McGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health CentreMcGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health CentreMcGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health CentreMcGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health CentreAbstract Proper recognition between axons and glial processes is required for the establishment of axon ensheathment in the developing nervous system. Recent studies have begun to reveal molecular events underlying developmental control of axon-glia recognition. In our previous work, we showed that the transmembrane protein Borderless (Bdl) is specifically expressed in wrapping glia (WG), and is required for the extension of glial processes and the ensheathment of photoreceptor axons in the developing Drosophila visual system. The exact mechanism by which Bdl mediates axon-glia recognition, however, remains unknown. Here, we present evidence showing that Bdl interacts with the Ig transmembrane protein Turtle (Tutl). Tutl is specifically expressed in photoreceptor axons. Loss of tutl in photoreceptors, like loss of bdl in WG, disrupts glial extension and axon ensheatment. Epistasis analysis shows that Tutl interacts genetically with Bdl. Tutl interacts with Bdl in trans in cultured cells. We propose that Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment.http://link.springer.com/article/10.1186/s13041-017-0299-6 |
| spellingShingle | Yixu Chen Scott Cameron Wen-Tzu Chang Yong Rao Turtle interacts with borderless in regulating glial extension and axon ensheathment Molecular Brain |
| title | Turtle interacts with borderless in regulating glial extension and axon ensheathment |
| title_full | Turtle interacts with borderless in regulating glial extension and axon ensheathment |
| title_fullStr | Turtle interacts with borderless in regulating glial extension and axon ensheathment |
| title_full_unstemmed | Turtle interacts with borderless in regulating glial extension and axon ensheathment |
| title_short | Turtle interacts with borderless in regulating glial extension and axon ensheathment |
| title_sort | turtle interacts with borderless in regulating glial extension and axon ensheathment |
| url | http://link.springer.com/article/10.1186/s13041-017-0299-6 |
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