P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA
Biomolecular behavior of tumor cells has become attractive to investigators. p53 as an oncosuppresor gene has been core of various studies and Ki67 is a nuclear protein involved in proliferation process. Stopping of onco-suppressor function theoretically allows proliferative system to get out of any...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2005-04-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/2977 |
| _version_ | 1819010583419158528 |
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| author | S. Saber P. Salehian |
| author_facet | S. Saber P. Salehian |
| author_sort | S. Saber |
| collection | DOAJ |
| description | Biomolecular behavior of tumor cells has become attractive to investigators. p53 as an
oncosuppresor gene has been core of various studies and Ki67 is a nuclear protein involved in proliferation process. Stopping of onco-suppressor function theoretically allows proliferative system to get out of any control. In this case-control study we evaluated 50 patients with non small cell lung cancer, considering the association between P53 oncoprotein and Ki67 with rate of tumoral cells differentiation. We found the concurrent move of P53 and Ki67 according to the rate of differentiation and a significant risk (odds ratio) for being poorly differentiated in samples having higher rates of these two factors. We suppose that mutant P53 protein not only may be used as an objective finding for tumor
grading, but probably as a practical point of approach for determining prognosis and planning therapy for this patients. |
| first_indexed | 2024-12-21T01:14:34Z |
| format | Article |
| id | doaj.art-907eeb2fb4034235b7fb0420a92284ed |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-21T01:14:34Z |
| publishDate | 2005-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-907eeb2fb4034235b7fb0420a92284ed2022-12-21T19:20:50ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942005-04-01432P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA S. Saber0 P. Salehian1 Biomolecular behavior of tumor cells has become attractive to investigators. p53 as an oncosuppresor gene has been core of various studies and Ki67 is a nuclear protein involved in proliferation process. Stopping of onco-suppressor function theoretically allows proliferative system to get out of any control. In this case-control study we evaluated 50 patients with non small cell lung cancer, considering the association between P53 oncoprotein and Ki67 with rate of tumoral cells differentiation. We found the concurrent move of P53 and Ki67 according to the rate of differentiation and a significant risk (odds ratio) for being poorly differentiated in samples having higher rates of these two factors. We suppose that mutant P53 protein not only may be used as an objective finding for tumor grading, but probably as a practical point of approach for determining prognosis and planning therapy for this patients.https://acta.tums.ac.ir/index.php/acta/article/view/2977Non-small-cell lung carcinomaKi67 antigen |
| spellingShingle | S. Saber P. Salehian P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA Acta Medica Iranica Non-small-cell lung carcinoma Ki67 antigen |
| title | P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA |
| title_full | P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA |
| title_fullStr | P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA |
| title_full_unstemmed | P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA |
| title_short | P53 AND Ki67 BIOMARKERS AS PROGNOSTIC FACTORS OF NON SMALL CELL LUNG CARCINOMA |
| title_sort | p53 and ki67 biomarkers as prognostic factors of non small cell lung carcinoma |
| topic | Non-small-cell lung carcinoma Ki67 antigen |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/2977 |
| work_keys_str_mv | AT ssaber p53andki67biomarkersasprognosticfactorsofnonsmallcelllungcarcinoma AT psalehian p53andki67biomarkersasprognosticfactorsofnonsmallcelllungcarcinoma |