The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population
Abstract Background Current studies support lipid ratios [the total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio; the triglyceride (TG)/HDL-C ratio; the low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio; and non-HDL-C] as reliable indicators of cardiovascular disease, s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-021-01556-z |
| _version_ | 1818367989080129536 |
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| author | Yu Yu Tian Lan Dandan Wang Wangsheng Fang Yu Tao Minghui Li Xiao Huang Wei Zhou Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng |
| author_facet | Yu Yu Tian Lan Dandan Wang Wangsheng Fang Yu Tao Minghui Li Xiao Huang Wei Zhou Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng |
| author_sort | Yu Yu |
| collection | DOAJ |
| description | Abstract Background Current studies support lipid ratios [the total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio; the triglyceride (TG)/HDL-C ratio; the low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio; and non-HDL-C] as reliable indicators of cardiovascular disease, stroke, and diabetes. However, whether lipid ratios could serve as markers for hyperuricemia (HUA) remains unclear due to limited research. This study aimed to explore the association between lipid ratios and HUA in hypertensive patients. Methods The data from 14,227 Chinese hypertensive individuals in the study were analyzed. Multiple logistic regression analysis and smooth curve fitting models examined the relationship between lipid ratios and HUA. Results The results showed positive associations between the lipid ratios and HUA (all P < 0.001). Furthermore, lipid ratios were converted from continuous variables to tertiles. Compared to the lowest tertile, the fully adjusted ORs (95 % CI) of the TC/HDL-C ratio, the TG/HDL-C ratio, the LDL-C/HDL-C ratio, and non-HDL-C in the highest tertile were 1.79 (1.62, 1.99), 2.09 (1.88, 2.32), 1.67 (1.51, 1.86), and 1.93 (1.74, 2.13), respectively (all P < 0.001). Conclusions The study suggested that high lipid ratios (TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C) are associated with HUA in a Chinese hypertensive population. This study’s findings further expand the scope of the application of lipid ratios. These novel and essential results suggest that lipid ratio profiles might be potential and valuable markers for HUA. Trial registration No. ChiCTR1800017274. Registered July 20, 2018. |
| first_indexed | 2024-12-13T23:00:48Z |
| format | Article |
| id | doaj.art-907ff9b9ea134dd1a5bbb8ca8fa537b8 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-13T23:00:48Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-907ff9b9ea134dd1a5bbb8ca8fa537b82022-12-21T23:28:24ZengBMCLipids in Health and Disease1476-511X2021-09-012011910.1186/s12944-021-01556-zThe association of lipid ratios with hyperuricemia in a rural Chinese hypertensive populationYu Yu0Tian Lan1Dandan Wang2Wangsheng Fang3Yu Tao4Minghui Li5Xiao Huang6Wei Zhou7Tao Wang8Lingjuan Zhu9Huihui Bao10Xiaoshu Cheng11Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Health Care Management, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityWuyuan County Health Committee, Wuyuan of JiangxiDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang of Jiangxi, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang of Jiangxi, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang of Jiangxi, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityAbstract Background Current studies support lipid ratios [the total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio; the triglyceride (TG)/HDL-C ratio; the low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio; and non-HDL-C] as reliable indicators of cardiovascular disease, stroke, and diabetes. However, whether lipid ratios could serve as markers for hyperuricemia (HUA) remains unclear due to limited research. This study aimed to explore the association between lipid ratios and HUA in hypertensive patients. Methods The data from 14,227 Chinese hypertensive individuals in the study were analyzed. Multiple logistic regression analysis and smooth curve fitting models examined the relationship between lipid ratios and HUA. Results The results showed positive associations between the lipid ratios and HUA (all P < 0.001). Furthermore, lipid ratios were converted from continuous variables to tertiles. Compared to the lowest tertile, the fully adjusted ORs (95 % CI) of the TC/HDL-C ratio, the TG/HDL-C ratio, the LDL-C/HDL-C ratio, and non-HDL-C in the highest tertile were 1.79 (1.62, 1.99), 2.09 (1.88, 2.32), 1.67 (1.51, 1.86), and 1.93 (1.74, 2.13), respectively (all P < 0.001). Conclusions The study suggested that high lipid ratios (TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C) are associated with HUA in a Chinese hypertensive population. This study’s findings further expand the scope of the application of lipid ratios. These novel and essential results suggest that lipid ratio profiles might be potential and valuable markers for HUA. Trial registration No. ChiCTR1800017274. Registered July 20, 2018.https://doi.org/10.1186/s12944-021-01556-zLipid ratiosHyperuricemiaHypertensionLipid ratiosHigh-density lipoprotein cholesterolRural China |
| spellingShingle | Yu Yu Tian Lan Dandan Wang Wangsheng Fang Yu Tao Minghui Li Xiao Huang Wei Zhou Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population Lipids in Health and Disease Lipid ratios Hyperuricemia Hypertension Lipid ratios High-density lipoprotein cholesterol Rural China |
| title | The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population |
| title_full | The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population |
| title_fullStr | The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population |
| title_full_unstemmed | The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population |
| title_short | The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population |
| title_sort | association of lipid ratios with hyperuricemia in a rural chinese hypertensive population |
| topic | Lipid ratios Hyperuricemia Hypertension Lipid ratios High-density lipoprotein cholesterol Rural China |
| url | https://doi.org/10.1186/s12944-021-01556-z |
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