Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection.

Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection.

<h4>Unlabelled</h4>In the RV144 HIV-1 vaccine efficacy trial, IgG antibody (Ab) binding levels to variable regions 1 and 2 (V1V2) of the HIV-1 envelope glycoprotein gp120 were an inverse correlate of risk of HIV-1 infection. To determine if V1V2-specific Abs cross-react with V1V2 from di...

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Bibliographic Details
Main Authors: Susan Zolla-Pazner, Allan deCamp, Peter B Gilbert, Constance Williams, Nicole L Yates, William T Williams, Robert Howington, Youyi Fong, Daryl E Morris, Kelly A Soderberg, Carmela Irene, Charles Reichman, Abraham Pinter, Robert Parks, Punnee Pitisuttithum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Charla Andrews, Robert J O'Connell, Zhi-yong Yang, Gary J Nabel, Jerome H Kim, Nelson L Michael, David C Montefiori, Hua-Xin Liao, Barton F Haynes, Georgia D Tomaras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24504509/pdf/?tool=EBI

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