Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation
BackgroundObesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Epicardial adipose tissue (EAT) may be a link between these associations. We sought to assess whether EAT is associated with body mass index...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-11-01
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Series: | Frontiers in Cardiovascular Medicine |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1045730/full |
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author | Yaacoub Chahine Bahareh Askari-Atapour Kirsten T. Kwan Carter A. Anderson Fima Macheret Tanzina Afroze Savannah F. Bifulco Matthew D. Cham Karen Ordovas Patrick M. Boyle Patrick M. Boyle Patrick M. Boyle Nazem Akoum Nazem Akoum |
author_facet | Yaacoub Chahine Bahareh Askari-Atapour Kirsten T. Kwan Carter A. Anderson Fima Macheret Tanzina Afroze Savannah F. Bifulco Matthew D. Cham Karen Ordovas Patrick M. Boyle Patrick M. Boyle Patrick M. Boyle Nazem Akoum Nazem Akoum |
author_sort | Yaacoub Chahine |
collection | DOAJ |
description | BackgroundObesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Epicardial adipose tissue (EAT) may be a link between these associations. We sought to assess whether EAT is associated with body mass index (BMI), left atrial (LA) fibrosis and volume.MethodsLA fibrosis and EAT were assessed using late gadolinium enhancement, and Dixon MRI sequences, respectively. We derived 3D models incorporating fibrosis and EAT, then measured the distance of fibrotic and non-fibrotic areas to the nearest EAT to assess spatial colocalization.ResultsOne hundred and three AF patients (64% paroxysmal, 27% female) were analyzed. LA volume index was 54.9 (41.2, 69.7) mL/m2, LA EAT index was 17.4 (12.7, 22.9) mL/m2, and LA fibrosis was 17.1 (12.4, 23.1)%. LA EAT was significantly correlated with BMI (R = 0.557, p < 0.001); as well as with LA volume and LA fibrosis after BSA adjustment (R = 0.579 and R = 0.432, respectively, p < 0.001 for both). Multivariable analysis showed LA EAT to be independently associated with LA volume and fibrosis. 3D registration of fat and fibrosis around the LA showed no clear spatial overlap between EAT and fibrotic LA regions.ConclusionLA EAT is associated with obesity (BMI) as well as LA volume and fibrosis. Regions of LA EAT did not colocalize with fibrotic areas, suggesting a systemic or paracrine mechanism rather than EAT infiltration of fibrotic areas. |
first_indexed | 2024-04-13T14:36:12Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 2297-055X |
language | English |
last_indexed | 2024-04-13T14:36:12Z |
publishDate | 2022-11-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Cardiovascular Medicine |
spelling | doaj.art-90813f639a114f8988c8bd1a095ea81e2022-12-22T02:43:02ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10457301045730Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillationYaacoub Chahine0Bahareh Askari-Atapour1Kirsten T. Kwan2Carter A. Anderson3Fima Macheret4Tanzina Afroze5Savannah F. Bifulco6Matthew D. Cham7Karen Ordovas8Patrick M. Boyle9Patrick M. Boyle10Patrick M. Boyle11Nazem Akoum12Nazem Akoum13Division of Cardiology, University of Washington, Seattle, WA, United StatesDivision of Cardiology, University of Washington, Seattle, WA, United StatesDepartment of Bioengineering, University of Washington, Seattle, WA, United StatesDepartment of Bioengineering, University of Washington, Seattle, WA, United StatesDivision of Cardiology, University of Washington, Seattle, WA, United StatesDivision of Cardiology, University of Washington, Seattle, WA, United StatesDepartment of Bioengineering, University of Washington, Seattle, WA, United StatesDepartment of Radiology, University of Washington, Seattle, WA, United StatesDepartment of Radiology, University of Washington, Seattle, WA, United StatesDepartment of Bioengineering, University of Washington, Seattle, WA, United StatesInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United StatesCenter for Cardiovascular Biology, University of Washington, Seattle, WA, United StatesDivision of Cardiology, University of Washington, Seattle, WA, United StatesDepartment of Bioengineering, University of Washington, Seattle, WA, United StatesBackgroundObesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Epicardial adipose tissue (EAT) may be a link between these associations. We sought to assess whether EAT is associated with body mass index (BMI), left atrial (LA) fibrosis and volume.MethodsLA fibrosis and EAT were assessed using late gadolinium enhancement, and Dixon MRI sequences, respectively. We derived 3D models incorporating fibrosis and EAT, then measured the distance of fibrotic and non-fibrotic areas to the nearest EAT to assess spatial colocalization.ResultsOne hundred and three AF patients (64% paroxysmal, 27% female) were analyzed. LA volume index was 54.9 (41.2, 69.7) mL/m2, LA EAT index was 17.4 (12.7, 22.9) mL/m2, and LA fibrosis was 17.1 (12.4, 23.1)%. LA EAT was significantly correlated with BMI (R = 0.557, p < 0.001); as well as with LA volume and LA fibrosis after BSA adjustment (R = 0.579 and R = 0.432, respectively, p < 0.001 for both). Multivariable analysis showed LA EAT to be independently associated with LA volume and fibrosis. 3D registration of fat and fibrosis around the LA showed no clear spatial overlap between EAT and fibrotic LA regions.ConclusionLA EAT is associated with obesity (BMI) as well as LA volume and fibrosis. Regions of LA EAT did not colocalize with fibrotic areas, suggesting a systemic or paracrine mechanism rather than EAT infiltration of fibrotic areas.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1045730/fullatrial fibrillationepicardial adipose tissuefibrosiscardiac magnetic resonance imagingDixon sequencelate gadolinium enhancement (LGE) MRI |
spellingShingle | Yaacoub Chahine Bahareh Askari-Atapour Kirsten T. Kwan Carter A. Anderson Fima Macheret Tanzina Afroze Savannah F. Bifulco Matthew D. Cham Karen Ordovas Patrick M. Boyle Patrick M. Boyle Patrick M. Boyle Nazem Akoum Nazem Akoum Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation Frontiers in Cardiovascular Medicine atrial fibrillation epicardial adipose tissue fibrosis cardiac magnetic resonance imaging Dixon sequence late gadolinium enhancement (LGE) MRI |
title | Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation |
title_full | Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation |
title_fullStr | Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation |
title_full_unstemmed | Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation |
title_short | Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation |
title_sort | epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation |
topic | atrial fibrillation epicardial adipose tissue fibrosis cardiac magnetic resonance imaging Dixon sequence late gadolinium enhancement (LGE) MRI |
url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1045730/full |
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