MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
Abstract Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological feature...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-022-00382-4 |
| _version_ | 1818533846933569536 |
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| author | Amir Abbas Hamidi Negin Taghehchian Zahra Basirat Amir Sadra Zangouei Meysam Moghbeli |
| author_facet | Amir Abbas Hamidi Negin Taghehchian Zahra Basirat Amir Sadra Zangouei Meysam Moghbeli |
| author_sort | Amir Abbas Hamidi |
| collection | DOAJ |
| description | Abstract Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigenetic modifications and non-coding RNAs are also involved in TC progression and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important biological process during tumor invasion and migration that affects the initiation and transformation of early-stage tumors into invasive malignancies. A combination of transcription factors, growth factors, signaling pathways, and epigenetic regulations affect the thyroid cell migration and EMT process. MicroRNAs (miRNAs) are important molecular factors involved in tumor metastasis by regulation of EMT-activating signaling pathways. Various miRNAs are involved in the signaling pathways associated with TC metastasis which can be used as diagnostic and therapeutic biomarkers. Since, the miRNAs are sensitive, specific, and non-invasive, they can be suggested as efficient and optimal biomarkers of tumor invasion and metastasis. In the present review, we have summarized all of the miRNAs which have been significantly involved in thyroid tumor cells migration and invasion. We also categorized all of the reported miRNAs based on their cellular processes to clarify the molecular role of miRNAs during thyroid tumor cell migration and invasion. This review paves the way of introducing a non-invasive diagnostic and prognostic panel of miRNAs in aggressive and metastatic TC patients. |
| first_indexed | 2024-12-11T18:04:08Z |
| format | Article |
| id | doaj.art-90819c0921134062b78778bd5edfe20f |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-11T18:04:08Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-90819c0921134062b78778bd5edfe20f2022-12-22T00:55:48ZengBMCBiomarker Research2050-77712022-06-0110112310.1186/s40364-022-00382-4MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancerAmir Abbas Hamidi0Negin Taghehchian1Zahra Basirat2Amir Sadra Zangouei3Meysam Moghbeli4Student Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesDepartment of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesAbstract Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigenetic modifications and non-coding RNAs are also involved in TC progression and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important biological process during tumor invasion and migration that affects the initiation and transformation of early-stage tumors into invasive malignancies. A combination of transcription factors, growth factors, signaling pathways, and epigenetic regulations affect the thyroid cell migration and EMT process. MicroRNAs (miRNAs) are important molecular factors involved in tumor metastasis by regulation of EMT-activating signaling pathways. Various miRNAs are involved in the signaling pathways associated with TC metastasis which can be used as diagnostic and therapeutic biomarkers. Since, the miRNAs are sensitive, specific, and non-invasive, they can be suggested as efficient and optimal biomarkers of tumor invasion and metastasis. In the present review, we have summarized all of the miRNAs which have been significantly involved in thyroid tumor cells migration and invasion. We also categorized all of the reported miRNAs based on their cellular processes to clarify the molecular role of miRNAs during thyroid tumor cell migration and invasion. This review paves the way of introducing a non-invasive diagnostic and prognostic panel of miRNAs in aggressive and metastatic TC patients.https://doi.org/10.1186/s40364-022-00382-4Thyroid cancermiRNAInvasionMetastasisMigrationPanel marker |
| spellingShingle | Amir Abbas Hamidi Negin Taghehchian Zahra Basirat Amir Sadra Zangouei Meysam Moghbeli MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer Biomarker Research Thyroid cancer miRNA Invasion Metastasis Migration Panel marker |
| title | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
| title_full | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
| title_fullStr | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
| title_full_unstemmed | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
| title_short | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
| title_sort | micrornas as the critical regulators of cell migration and invasion in thyroid cancer |
| topic | Thyroid cancer miRNA Invasion Metastasis Migration Panel marker |
| url | https://doi.org/10.1186/s40364-022-00382-4 |
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