Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death

Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death

Lipid peroxidation products have been known to induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through up-regulation of antioxidant compounds and enzymes. 24S-hydroxycholesterol (24SOHC) which is endogenously produced oxysterol in the brain plays an impor...

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Bibliographic Details
Main Authors: Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, Noriko Noguchi
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Cell death
Adaptive responses
Liver X receptor
24S-hydroxycholesterol
7-ketocholesterol
ATP-binding cassette transporter G1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713000876

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