Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice
Kresoxim-methyl is a high-efficiency and broad-spectrum fungicide used for the control of rice fungal diseases; however, its residues after application potentially threaten human health. Investigations on the dissipation of kresoxim-methyl residue in rice field systems and dietary risk assessment of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/4/692 |
| _version_ | 1818941206324838400 |
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| author | MingNa Sun Lu Yu Zhou Tong Xu Dong Yue Chu Mei Wang TongChun Gao JinSheng Duan |
| author_facet | MingNa Sun Lu Yu Zhou Tong Xu Dong Yue Chu Mei Wang TongChun Gao JinSheng Duan |
| author_sort | MingNa Sun |
| collection | DOAJ |
| description | Kresoxim-methyl is a high-efficiency and broad-spectrum fungicide used for the control of rice fungal diseases; however, its residues after application potentially threaten human health. Investigations on the dissipation of kresoxim-methyl residue in rice field systems and dietary risk assessment of kresoxim-methyl in humans are limited. The present study employed the QuEChERS-GC-MS/MS method for residue analysis of kresoxim-methyl in rice plants, brown rice, and rice husks. The samples were extracted with acetonitrile and purified by PSA, C<sub>18</sub> column, and GCB. The average recovery of the spiked target compounds in the three matrices was between 80.5% and 99.3%, and the RSD was between 2.1% and 7.1%. The accuracy and precision of the method is in accordance with the requirements of residue analysis methods. Dissipation dynamic testing of kresoxim-methyl in rice plants indicated a half-life within the range of 1.8⁻6.0 days, and a rapid dissipation rate was detected. Dietary intake risk assessment showed that the national estimated daily intake (<i>NEDI</i>) of kresoxim-methyl in various Chinese subpopulations was 0.022⁻0.054 μg/(kg bw·days), and the risk quotient (<i>RQ</i>) was 0.0000055⁻0.00014%. These findings indicate that the risk for chronic dietary intake of kresoxim-methyl in brown rice is relatively low. The present study provides information and theoretical basis for guiding the scientific use of kresoxim-methyl in rice fields and evaluating its dietary risk in brown rice. |
| first_indexed | 2024-12-20T06:51:51Z |
| format | Article |
| id | doaj.art-90827bf1b3e54912ad3097804686ed4c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T06:51:51Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-90827bf1b3e54912ad3097804686ed4c2022-12-21T19:49:32ZengMDPI AGMolecules1420-30492019-02-0124469210.3390/molecules24040692molecules24040692Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in RiceMingNa Sun0Lu Yu1Zhou Tong2Xu Dong3Yue Chu4Mei Wang5TongChun Gao6JinSheng Duan7Institute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaInstitute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaKresoxim-methyl is a high-efficiency and broad-spectrum fungicide used for the control of rice fungal diseases; however, its residues after application potentially threaten human health. Investigations on the dissipation of kresoxim-methyl residue in rice field systems and dietary risk assessment of kresoxim-methyl in humans are limited. The present study employed the QuEChERS-GC-MS/MS method for residue analysis of kresoxim-methyl in rice plants, brown rice, and rice husks. The samples were extracted with acetonitrile and purified by PSA, C<sub>18</sub> column, and GCB. The average recovery of the spiked target compounds in the three matrices was between 80.5% and 99.3%, and the RSD was between 2.1% and 7.1%. The accuracy and precision of the method is in accordance with the requirements of residue analysis methods. Dissipation dynamic testing of kresoxim-methyl in rice plants indicated a half-life within the range of 1.8⁻6.0 days, and a rapid dissipation rate was detected. Dietary intake risk assessment showed that the national estimated daily intake (<i>NEDI</i>) of kresoxim-methyl in various Chinese subpopulations was 0.022⁻0.054 μg/(kg bw·days), and the risk quotient (<i>RQ</i>) was 0.0000055⁻0.00014%. These findings indicate that the risk for chronic dietary intake of kresoxim-methyl in brown rice is relatively low. The present study provides information and theoretical basis for guiding the scientific use of kresoxim-methyl in rice fields and evaluating its dietary risk in brown rice.https://www.mdpi.com/1420-3049/24/4/692ricekresoxim-methyldissipationrisk assessment |
| spellingShingle | MingNa Sun Lu Yu Zhou Tong Xu Dong Yue Chu Mei Wang TongChun Gao JinSheng Duan Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice Molecules rice kresoxim-methyl dissipation risk assessment |
| title | Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice |
| title_full | Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice |
| title_fullStr | Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice |
| title_full_unstemmed | Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice |
| title_short | Dissipation Dynamics and Dietary Risk Assessment of Kresoxim-Methyl Residue in Rice |
| title_sort | dissipation dynamics and dietary risk assessment of kresoxim methyl residue in rice |
| topic | rice kresoxim-methyl dissipation risk assessment |
| url | https://www.mdpi.com/1420-3049/24/4/692 |
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