MiRNAs and Their Role in Venous Thromboembolic Complications
Venous thromboembolic complications (VTCs), which include deep vein thrombosis (DVT) and pulmonary embolism (PE), have remained a pressing problem in modern clinical medicine for a long time. Despite the already wide arsenal of modern methods for diagnosing and treating this disease, VTCs rank third...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/21/3383 |
| _version_ | 1827765736321318912 |
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| author | Ilgiz Gareev Valentin Pavlov Weijie Du Baofeng Yang |
| author_facet | Ilgiz Gareev Valentin Pavlov Weijie Du Baofeng Yang |
| author_sort | Ilgiz Gareev |
| collection | DOAJ |
| description | Venous thromboembolic complications (VTCs), which include deep vein thrombosis (DVT) and pulmonary embolism (PE), have remained a pressing problem in modern clinical medicine for a long time. Despite the already wide arsenal of modern methods for diagnosing and treating this disease, VTCs rank third in the structure of causes of death among all cardiovascular diseases, behind myocardial infarction (MI) and ischemic stroke (IS). Numerous studies have confirmed the importance of understanding the molecular processes of VTCs for effective therapy and diagnosis. Significant progress has been made in VTC research in recent years, where the relative contribution of microRNAs (miRNAs) in the mechanism of thrombus formation and their consideration as therapeutic targets have been well studied. In this case, accurate, timely, and as early as possible diagnosis of VTCs is of particular importance, which will help improve both short-term and long-term prognoses of patients. This case accounts for the already well-studied circulating miRNAs as non-invasive biomarkers. This study presents currently available literature data on the role of miRNAs in VTCs, revealing their potential as therapeutic targets and diagnostic and prognostic tools for this terrible disease. |
| first_indexed | 2024-03-11T11:31:49Z |
| format | Article |
| id | doaj.art-90835da170f247e1abc011095e2bdfe7 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T11:31:49Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-90835da170f247e1abc011095e2bdfe72023-11-10T15:01:10ZengMDPI AGDiagnostics2075-44182023-11-011321338310.3390/diagnostics13213383MiRNAs and Their Role in Venous Thromboembolic ComplicationsIlgiz Gareev0Valentin Pavlov1Weijie Du2Baofeng Yang3Central Research Laboratory, Bashkir State Medical University, 3 Lenin Street, 450008 Ufa, RussiaDepartment of Urology, Bashkir State Medical University, 3 Lenin Street, 450008 Ufa, RussiaDepartment of Pharmacology, The Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150067, ChinaDepartment of Pharmacology, The Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150067, ChinaVenous thromboembolic complications (VTCs), which include deep vein thrombosis (DVT) and pulmonary embolism (PE), have remained a pressing problem in modern clinical medicine for a long time. Despite the already wide arsenal of modern methods for diagnosing and treating this disease, VTCs rank third in the structure of causes of death among all cardiovascular diseases, behind myocardial infarction (MI) and ischemic stroke (IS). Numerous studies have confirmed the importance of understanding the molecular processes of VTCs for effective therapy and diagnosis. Significant progress has been made in VTC research in recent years, where the relative contribution of microRNAs (miRNAs) in the mechanism of thrombus formation and their consideration as therapeutic targets have been well studied. In this case, accurate, timely, and as early as possible diagnosis of VTCs is of particular importance, which will help improve both short-term and long-term prognoses of patients. This case accounts for the already well-studied circulating miRNAs as non-invasive biomarkers. This study presents currently available literature data on the role of miRNAs in VTCs, revealing their potential as therapeutic targets and diagnostic and prognostic tools for this terrible disease.https://www.mdpi.com/2075-4418/13/21/3383miRNAvenous thromboembolic complicationscardiovascular diseasehemostasistherapeutic targetsbiomarkers |
| spellingShingle | Ilgiz Gareev Valentin Pavlov Weijie Du Baofeng Yang MiRNAs and Their Role in Venous Thromboembolic Complications Diagnostics miRNA venous thromboembolic complications cardiovascular disease hemostasis therapeutic targets biomarkers |
| title | MiRNAs and Their Role in Venous Thromboembolic Complications |
| title_full | MiRNAs and Their Role in Venous Thromboembolic Complications |
| title_fullStr | MiRNAs and Their Role in Venous Thromboembolic Complications |
| title_full_unstemmed | MiRNAs and Their Role in Venous Thromboembolic Complications |
| title_short | MiRNAs and Their Role in Venous Thromboembolic Complications |
| title_sort | mirnas and their role in venous thromboembolic complications |
| topic | miRNA venous thromboembolic complications cardiovascular disease hemostasis therapeutic targets biomarkers |
| url | https://www.mdpi.com/2075-4418/13/21/3383 |
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