Clinical and immunological profile of patients with schizophrenia
Introduction The question of the involvement of inflammatory and autoimmune processes in schizophrenia pathogenesis has become the most relevant in the last decade and yet is not fully understood. Objectives The study included 60 patients with paranoid schizophrenia (age 18 - 55 y.o.) and 30 heal...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Cambridge University Press
2022-06-01
|
Series: | European Psychiatry |
Subjects: | |
Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822003017/type/journal_article |
_version_ | 1797616862650957824 |
---|---|
author | N. Petrova M. Mayorova L. Churilov A. Gvozdetskiy I. Kudryavtsev P. Sobolevskaia V. Serazetdinova |
author_facet | N. Petrova M. Mayorova L. Churilov A. Gvozdetskiy I. Kudryavtsev P. Sobolevskaia V. Serazetdinova |
author_sort | N. Petrova |
collection | DOAJ |
description |
Introduction
The question of the involvement of inflammatory and autoimmune processes in schizophrenia pathogenesis has become the most relevant in the last decade and yet is not fully understood.
Objectives
The study included 60 patients with paranoid schizophrenia (age 18 - 55 y.o.) and 30 healthy control group participants. Patients were in a stabilization state without a history of organic brain disorder or another verified somatic disease in the exacerbation phase.
Methods
Research methods included follow-up method, neuropsychological (PANSS, BAC-S), laboratory (enzyme immunoassay, flow cytometry), and statistical.
Results
Patients with schizophrenia had significant structural disorders of thinking, passive, apathetic withdrawal, negativism, impaired attention, psychomotor speed, volitional impulses. Cognitive impairment was detected in all study participants. Severe impairments are noted in the executive functioning, hand-eye coordination, attention, psychomotor speed. The severity of cognitive impairments correlated with the severity of clinical symptoms. Patients with schizophrenia had a significant decrease in central memory T-regulators levels, and an increase in Th1 and Th2 subsets, «double-positive» and «сlassic» Th17, Tfh2, «classic» Tfh17, and in Tfh17.1 (Pic.1).
Picture. 1. T-helper subsets in patients with schizophrenia. They also had high levels of CCL20, IL-10, IL-12, IL-1β, IL-27, IL-31, IL-4, IL-13, IL-6, IL-9, TNFα in comparison with a control group. A significantly decreased levels of IL-17A, IL-17F, IL-2, IL-22, and TNFβ were also described in this group of patients.
Conclusions
Patients with schizophrenia may be characterized by the presence of an inflammatory process and a high chance of autoimmunity. Aknowledgement. This work was supported by the grant of the Russian Federation Government, contract 14.W03.31.0009
Disclosure
No significant relationships.
|
first_indexed | 2024-03-11T07:47:24Z |
format | Article |
id | doaj.art-9083a9c57e884f51b3c0a8b48def5fe5 |
institution | Directory Open Access Journal |
issn | 0924-9338 1778-3585 |
language | English |
last_indexed | 2024-03-11T07:47:24Z |
publishDate | 2022-06-01 |
publisher | Cambridge University Press |
record_format | Article |
series | European Psychiatry |
spelling | doaj.art-9083a9c57e884f51b3c0a8b48def5fe52023-11-17T05:07:19ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S105S10610.1192/j.eurpsy.2022.301Clinical and immunological profile of patients with schizophreniaN. Petrova0M. Mayorova1L. Churilov2A. Gvozdetskiy3I. Kudryavtsev4P. Sobolevskaia5V. Serazetdinova6Saint-Petersburg State University, Department Of Psychiatry And Addiction, Saint-Petersburg, Russian FederationSaint Petersburg State University, Laboratory Of Mosaic Of Autoimmunity, Saint-Petersburg, Russian FederationSaint Petersburg State University, Laboratory Of Mosaic Of Autoimmunity, Saint-Petersburg, Russian FederationNorth-western State Medical university named after I. I. Mechnikov, Chair Of Psychiatry And Addiction, Saint-Petersburg, Russian FederationFSBSI Institute of experimental medicine, Department Of Immunology, Saint-Petersburg, Russian FederationSaint Petersburg State University, Laboratory Of Mosaic Of Autoimmunity, Saint-Petersburg, Russian FederationSaint-Petersburg FSBI Psychoneurological dispensary № 5, Day Hospital Department, Saint-Petersburg, Russian Federation Introduction The question of the involvement of inflammatory and autoimmune processes in schizophrenia pathogenesis has become the most relevant in the last decade and yet is not fully understood. Objectives The study included 60 patients with paranoid schizophrenia (age 18 - 55 y.o.) and 30 healthy control group participants. Patients were in a stabilization state without a history of organic brain disorder or another verified somatic disease in the exacerbation phase. Methods Research methods included follow-up method, neuropsychological (PANSS, BAC-S), laboratory (enzyme immunoassay, flow cytometry), and statistical. Results Patients with schizophrenia had significant structural disorders of thinking, passive, apathetic withdrawal, negativism, impaired attention, psychomotor speed, volitional impulses. Cognitive impairment was detected in all study participants. Severe impairments are noted in the executive functioning, hand-eye coordination, attention, psychomotor speed. The severity of cognitive impairments correlated with the severity of clinical symptoms. Patients with schizophrenia had a significant decrease in central memory T-regulators levels, and an increase in Th1 and Th2 subsets, «double-positive» and «сlassic» Th17, Tfh2, «classic» Tfh17, and in Tfh17.1 (Pic.1). Picture. 1. T-helper subsets in patients with schizophrenia. They also had high levels of CCL20, IL-10, IL-12, IL-1β, IL-27, IL-31, IL-4, IL-13, IL-6, IL-9, TNFα in comparison with a control group. A significantly decreased levels of IL-17A, IL-17F, IL-2, IL-22, and TNFβ were also described in this group of patients. Conclusions Patients with schizophrenia may be characterized by the presence of an inflammatory process and a high chance of autoimmunity. Aknowledgement. This work was supported by the grant of the Russian Federation Government, contract 14.W03.31.0009 Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822003017/type/journal_articleschizophréniaCytokinesautoimmunitylymphocytes subsets |
spellingShingle | N. Petrova M. Mayorova L. Churilov A. Gvozdetskiy I. Kudryavtsev P. Sobolevskaia V. Serazetdinova Clinical and immunological profile of patients with schizophrenia European Psychiatry schizophrénia Cytokines autoimmunity lymphocytes subsets |
title | Clinical and immunological profile of patients with schizophrenia |
title_full | Clinical and immunological profile of patients with schizophrenia |
title_fullStr | Clinical and immunological profile of patients with schizophrenia |
title_full_unstemmed | Clinical and immunological profile of patients with schizophrenia |
title_short | Clinical and immunological profile of patients with schizophrenia |
title_sort | clinical and immunological profile of patients with schizophrenia |
topic | schizophrénia Cytokines autoimmunity lymphocytes subsets |
url | https://www.cambridge.org/core/product/identifier/S0924933822003017/type/journal_article |
work_keys_str_mv | AT npetrova clinicalandimmunologicalprofileofpatientswithschizophrenia AT mmayorova clinicalandimmunologicalprofileofpatientswithschizophrenia AT lchurilov clinicalandimmunologicalprofileofpatientswithschizophrenia AT agvozdetskiy clinicalandimmunologicalprofileofpatientswithschizophrenia AT ikudryavtsev clinicalandimmunologicalprofileofpatientswithschizophrenia AT psobolevskaia clinicalandimmunologicalprofileofpatientswithschizophrenia AT vserazetdinova clinicalandimmunologicalprofileofpatientswithschizophrenia |