Clinical and immunological profile of patients with schizophrenia

Introduction The question of the involvement of inflammatory and autoimmune processes in schizophrenia pathogenesis has become the most relevant in the last decade and yet is not fully understood. Objectives The study included 60 patients with paranoid schizophrenia (age 18 - 55 y.o.) and 30 heal...

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Main Authors: N. Petrova, M. Mayorova, L. Churilov, A. Gvozdetskiy, I. Kudryavtsev, P. Sobolevskaia, V. Serazetdinova
Format: Article
Language:English
Published: Cambridge University Press 2022-06-01
Series:European Psychiatry
Subjects:
Online Access:https://www.cambridge.org/core/product/identifier/S0924933822003017/type/journal_article
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author N. Petrova
M. Mayorova
L. Churilov
A. Gvozdetskiy
I. Kudryavtsev
P. Sobolevskaia
V. Serazetdinova
author_facet N. Petrova
M. Mayorova
L. Churilov
A. Gvozdetskiy
I. Kudryavtsev
P. Sobolevskaia
V. Serazetdinova
author_sort N. Petrova
collection DOAJ
description Introduction The question of the involvement of inflammatory and autoimmune processes in schizophrenia pathogenesis has become the most relevant in the last decade and yet is not fully understood. Objectives The study included 60 patients with paranoid schizophrenia (age 18 - 55 y.o.) and 30 healthy control group participants. Patients were in a stabilization state without a history of organic brain disorder or another verified somatic disease in the exacerbation phase. Methods Research methods included follow-up method, neuropsychological (PANSS, BAC-S), laboratory (enzyme immunoassay, flow cytometry), and statistical. Results Patients with schizophrenia had significant structural disorders of thinking, passive, apathetic withdrawal, negativism, impaired attention, psychomotor speed, volitional impulses. Cognitive impairment was detected in all study participants. Severe impairments are noted in the executive functioning, hand-eye coordination, attention, psychomotor speed. The severity of cognitive impairments correlated with the severity of clinical symptoms. Patients with schizophrenia had a significant decrease in central memory T-regulators levels, and an increase in Th1 and Th2 subsets, «double-positive» and «сlassic» Th17, Tfh2, «classic» Tfh17, and in Tfh17.1 (Pic.1). Picture. 1. T-helper subsets in patients with schizophrenia. They also had high levels of CCL20, IL-10, IL-12, IL-1β, IL-27, IL-31, IL-4, IL-13, IL-6, IL-9, TNFα in comparison with a control group. A significantly decreased levels of IL-17A, IL-17F, IL-2, IL-22, and TNFβ were also described in this group of patients. Conclusions Patients with schizophrenia may be characterized by the presence of an inflammatory process and a high chance of autoimmunity. Aknowledgement. This work was supported by the grant of the Russian Federation Government, contract 14.W03.31.0009 Disclosure No significant relationships.
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spelling doaj.art-9083a9c57e884f51b3c0a8b48def5fe52023-11-17T05:07:19ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S105S10610.1192/j.eurpsy.2022.301Clinical and immunological profile of patients with schizophreniaN. Petrova0M. Mayorova1L. Churilov2A. Gvozdetskiy3I. Kudryavtsev4P. Sobolevskaia5V. Serazetdinova6Saint-Petersburg State University, Department Of Psychiatry And Addiction, Saint-Petersburg, Russian FederationSaint Petersburg State University, Laboratory Of Mosaic Of Autoimmunity, Saint-Petersburg, Russian FederationSaint Petersburg State University, Laboratory Of Mosaic Of Autoimmunity, Saint-Petersburg, Russian FederationNorth-western State Medical university named after I. I. Mechnikov, Chair Of Psychiatry And Addiction, Saint-Petersburg, Russian FederationFSBSI Institute of experimental medicine, Department Of Immunology, Saint-Petersburg, Russian FederationSaint Petersburg State University, Laboratory Of Mosaic Of Autoimmunity, Saint-Petersburg, Russian FederationSaint-Petersburg FSBI Psychoneurological dispensary № 5, Day Hospital Department, Saint-Petersburg, Russian Federation Introduction The question of the involvement of inflammatory and autoimmune processes in schizophrenia pathogenesis has become the most relevant in the last decade and yet is not fully understood. Objectives The study included 60 patients with paranoid schizophrenia (age 18 - 55 y.o.) and 30 healthy control group participants. Patients were in a stabilization state without a history of organic brain disorder or another verified somatic disease in the exacerbation phase. Methods Research methods included follow-up method, neuropsychological (PANSS, BAC-S), laboratory (enzyme immunoassay, flow cytometry), and statistical. Results Patients with schizophrenia had significant structural disorders of thinking, passive, apathetic withdrawal, negativism, impaired attention, psychomotor speed, volitional impulses. Cognitive impairment was detected in all study participants. Severe impairments are noted in the executive functioning, hand-eye coordination, attention, psychomotor speed. The severity of cognitive impairments correlated with the severity of clinical symptoms. Patients with schizophrenia had a significant decrease in central memory T-regulators levels, and an increase in Th1 and Th2 subsets, «double-positive» and «сlassic» Th17, Tfh2, «classic» Tfh17, and in Tfh17.1 (Pic.1). Picture. 1. T-helper subsets in patients with schizophrenia. They also had high levels of CCL20, IL-10, IL-12, IL-1β, IL-27, IL-31, IL-4, IL-13, IL-6, IL-9, TNFα in comparison with a control group. A significantly decreased levels of IL-17A, IL-17F, IL-2, IL-22, and TNFβ were also described in this group of patients. Conclusions Patients with schizophrenia may be characterized by the presence of an inflammatory process and a high chance of autoimmunity. Aknowledgement. This work was supported by the grant of the Russian Federation Government, contract 14.W03.31.0009 Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822003017/type/journal_articleschizophréniaCytokinesautoimmunitylymphocytes subsets
spellingShingle N. Petrova
M. Mayorova
L. Churilov
A. Gvozdetskiy
I. Kudryavtsev
P. Sobolevskaia
V. Serazetdinova
Clinical and immunological profile of patients with schizophrenia
European Psychiatry
schizophrénia
Cytokines
autoimmunity
lymphocytes subsets
title Clinical and immunological profile of patients with schizophrenia
title_full Clinical and immunological profile of patients with schizophrenia
title_fullStr Clinical and immunological profile of patients with schizophrenia
title_full_unstemmed Clinical and immunological profile of patients with schizophrenia
title_short Clinical and immunological profile of patients with schizophrenia
title_sort clinical and immunological profile of patients with schizophrenia
topic schizophrénia
Cytokines
autoimmunity
lymphocytes subsets
url https://www.cambridge.org/core/product/identifier/S0924933822003017/type/journal_article
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AT ikudryavtsev clinicalandimmunologicalprofileofpatientswithschizophrenia
AT psobolevskaia clinicalandimmunologicalprofileofpatientswithschizophrenia
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