Involvement of Interleukin 6 in Hepatitis B Viral Infection
Hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the...
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2015-09-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | http://www.karger.com/Article/FullText/430386 |
| _version_ | 1818475451849375744 |
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| author | Caixia Xia Yanning Liu Zhi Chen Min Zheng |
| author_facet | Caixia Xia Yanning Liu Zhi Chen Min Zheng |
| author_sort | Caixia Xia |
| collection | DOAJ |
| description | Hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the gene is located in chromosome 7p21. For healthy people, serum IL-6 levels are usually too low to be detected. However, dysregulated synthesis of IL-6 has been discovered in chronic inflammatory diseases such as hepatitis B, Crohn's disease and rheumatoid arthritis. IL-6 also plays an important role in HBV replication and in the development of hepatitis B disease. This review aims to present the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease. |
| first_indexed | 2024-12-10T09:12:45Z |
| format | Article |
| id | doaj.art-90858fe54aeb45a4a8caa1e01689858e |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-10T09:12:45Z |
| publishDate | 2015-09-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-90858fe54aeb45a4a8caa1e01689858e2022-12-22T01:54:57ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782015-09-0137267768610.1159/000430386430386Involvement of Interleukin 6 in Hepatitis B Viral InfectionCaixia XiaYanning LiuZhi ChenMin ZhengHepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the gene is located in chromosome 7p21. For healthy people, serum IL-6 levels are usually too low to be detected. However, dysregulated synthesis of IL-6 has been discovered in chronic inflammatory diseases such as hepatitis B, Crohn's disease and rheumatoid arthritis. IL-6 also plays an important role in HBV replication and in the development of hepatitis B disease. This review aims to present the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease.http://www.karger.com/Article/FullText/430386SNPInterleukin 6Hepatitis BHBx |
| spellingShingle | Caixia Xia Yanning Liu Zhi Chen Min Zheng Involvement of Interleukin 6 in Hepatitis B Viral Infection Cellular Physiology and Biochemistry SNP Interleukin 6 Hepatitis B HBx |
| title | Involvement of Interleukin 6 in Hepatitis B Viral Infection |
| title_full | Involvement of Interleukin 6 in Hepatitis B Viral Infection |
| title_fullStr | Involvement of Interleukin 6 in Hepatitis B Viral Infection |
| title_full_unstemmed | Involvement of Interleukin 6 in Hepatitis B Viral Infection |
| title_short | Involvement of Interleukin 6 in Hepatitis B Viral Infection |
| title_sort | involvement of interleukin 6 in hepatitis b viral infection |
| topic | SNP Interleukin 6 Hepatitis B HBx |
| url | http://www.karger.com/Article/FullText/430386 |
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