Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Abstract Background Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution of chemokines in the tumor microenvironment to tumor metastasis is not fully understood. Methods Herein, we examinined several chemokines in colorectal cancer patients using chemok...

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Bibliographic Details
Main Authors: Jingkun Zhao, Baochi Ou, Dingpei Han, Puxiongzhi Wang, Yaping Zong, Congcong Zhu, Di Liu, Minhua Zheng, Jing Sun, Hao Feng, Aiguo Lu
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Molecular Cancer
Subjects:
CXCL5
Colorectal cancer
EMT
Snail
β-catenin
Online Access:http://link.springer.com/article/10.1186/s12943-017-0629-4

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http://link.springer.com/article/10.1186/s12943-017-0629-4

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