Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia
Daniel Gebretsadik,1 Nuru Ahmed,2 Edosa Kebede,1 Miftah Mohammed,1 Melaku Ashagrie Belete1 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Ataye District Hospital, Ataye, EthiopiaCorrespondence: Daniel Gebretsadik Email gebrets...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-05-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/prevalence-of-tuberculosis-by-automated-genexpert-rifampicin-assay-and-peer-reviewed-article-IDR |
| _version_ | 1818119173009571840 |
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| author | Gebretsadik D Ahmed N Kebede E Mohammed M Belete MA |
| author_facet | Gebretsadik D Ahmed N Kebede E Mohammed M Belete MA |
| author_sort | Gebretsadik D |
| collection | DOAJ |
| description | Daniel Gebretsadik,1 Nuru Ahmed,2 Edosa Kebede,1 Miftah Mohammed,1 Melaku Ashagrie Belete1 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Ataye District Hospital, Ataye, EthiopiaCorrespondence: Daniel Gebretsadik Email gebretsadikd@gmail.comBackground: Tuberculosis is a communicable disease that is a major cause of ill health, one of the top 10 causes of death worldwide, and the leading cause of death from a single infectious agent, even ranking above human immuno-deficiency virus (HIV/AIDS).Objective: To assess the prevalence and associated risk factor of Mycobacterium tuberculosis among pulmonary tuberculosis (PTB) suspects attending at Ataye District Hospital from October 1, 2018, to February 30, 2019.Methodology: A facility-based cross-sectional study was conducted among 423 presumptive tuberculosis patients at Ataye District Hospital. Sputum was processed by MTB/RIF Xpert assay. Data were entered into EpiData 3.1 software and exported to SPSS version 20.0 (SPSS, Chicago, IL, USA) for analysis. Univariate and multivariate analyses were used to examine the relationship between the dependent and independent variables. Variables that show significance at P-value of 0.3 during univariate analysis were selected for multivariable analysis. A P-value of less than or equal to 0.05 was used to indicate statistical significance.Results: Out of the total study participants, about 60% were male, and 39% were aged between 18 and 24 years. Of the total 423 PTB suspected patients, 38 (8.98%) of them were identified as having PTB by GeneXpert and 2/38 (5.3%) were resistant to rifampicin and 3/38 (7.89%) patients were co-infected with HIV. Participant age between 18 and 24 years and between 25 and 34 years, weight loss, chest pain, having contact history with confirmed PTB cases, utilization of congested transportation, and a history of imprisonment were significantly associated with the prevalence of PTB.Conclusion: A considerable prevalence of PTB in the area was observed and the magnitude of MDR-TB was low. PTB is still a public health problem in Ethiopia and there is a need for collaborative prevention and control activities in the study area.Keywords: PTB, Ataye, MTB/RIF Xpert assay, Ethiopia |
| first_indexed | 2024-12-11T05:05:59Z |
| format | Article |
| id | doaj.art-908a65a6c622447197b5a9e9dd4e3162 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T05:05:59Z |
| publishDate | 2020-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-908a65a6c622447197b5a9e9dd4e31622022-12-22T01:20:02ZengDove Medical PressInfection and Drug Resistance1178-69732020-05-01Volume 131507151653948Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East EthiopiaGebretsadik DAhmed NKebede EMohammed MBelete MADaniel Gebretsadik,1 Nuru Ahmed,2 Edosa Kebede,1 Miftah Mohammed,1 Melaku Ashagrie Belete1 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Ataye District Hospital, Ataye, EthiopiaCorrespondence: Daniel Gebretsadik Email gebretsadikd@gmail.comBackground: Tuberculosis is a communicable disease that is a major cause of ill health, one of the top 10 causes of death worldwide, and the leading cause of death from a single infectious agent, even ranking above human immuno-deficiency virus (HIV/AIDS).Objective: To assess the prevalence and associated risk factor of Mycobacterium tuberculosis among pulmonary tuberculosis (PTB) suspects attending at Ataye District Hospital from October 1, 2018, to February 30, 2019.Methodology: A facility-based cross-sectional study was conducted among 423 presumptive tuberculosis patients at Ataye District Hospital. Sputum was processed by MTB/RIF Xpert assay. Data were entered into EpiData 3.1 software and exported to SPSS version 20.0 (SPSS, Chicago, IL, USA) for analysis. Univariate and multivariate analyses were used to examine the relationship between the dependent and independent variables. Variables that show significance at P-value of 0.3 during univariate analysis were selected for multivariable analysis. A P-value of less than or equal to 0.05 was used to indicate statistical significance.Results: Out of the total study participants, about 60% were male, and 39% were aged between 18 and 24 years. Of the total 423 PTB suspected patients, 38 (8.98%) of them were identified as having PTB by GeneXpert and 2/38 (5.3%) were resistant to rifampicin and 3/38 (7.89%) patients were co-infected with HIV. Participant age between 18 and 24 years and between 25 and 34 years, weight loss, chest pain, having contact history with confirmed PTB cases, utilization of congested transportation, and a history of imprisonment were significantly associated with the prevalence of PTB.Conclusion: A considerable prevalence of PTB in the area was observed and the magnitude of MDR-TB was low. PTB is still a public health problem in Ethiopia and there is a need for collaborative prevention and control activities in the study area.Keywords: PTB, Ataye, MTB/RIF Xpert assay, Ethiopiahttps://www.dovepress.com/prevalence-of-tuberculosis-by-automated-genexpert-rifampicin-assay-and-peer-reviewed-article-IDRptbatayemtb/rif xpert assayethiopia |
| spellingShingle | Gebretsadik D Ahmed N Kebede E Mohammed M Belete MA Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia Infection and Drug Resistance ptb ataye mtb/rif xpert assay ethiopia |
| title | Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia |
| title_full | Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia |
| title_fullStr | Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia |
| title_full_unstemmed | Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia |
| title_short | Prevalence of Tuberculosis by Automated GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive Pulmonary Tuberculosis Patients at Ataye District Hospital, North East Ethiopia |
| title_sort | prevalence of tuberculosis by automated genexpert rifampicin assay and associated risk factors among presumptive pulmonary tuberculosis patients at ataye district hospital north east ethiopia |
| topic | ptb ataye mtb/rif xpert assay ethiopia |
| url | https://www.dovepress.com/prevalence-of-tuberculosis-by-automated-genexpert-rifampicin-assay-and-peer-reviewed-article-IDR |
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