Genotypical diversity of HIV clades and central nervous system impairment
The central nervous system (CNS) and the immune system are considered major target organs for HIV infection. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV associated dementia, vacuolar myelopathy and involvement of the peripheral nervous...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2011-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700023&lng=en&tlng=en |
| _version_ | 1819161470840078336 |
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| author | Indianara Rotta Sérgio Monteiro de Almeida |
| author_facet | Indianara Rotta Sérgio Monteiro de Almeida |
| author_sort | Indianara Rotta |
| collection | DOAJ |
| description | The central nervous system (CNS) and the immune system are considered major target organs for HIV infection. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV associated dementia, vacuolar myelopathy and involvement of the peripheral nervous system. Changes in diagnosis and clinical management have changed the aspect of HIV infection so that it is no longer a fatal disease, and has become a chronic disease requiring sustained medical management. After HAART the incidence of most opportunistic infections, including those affecting the CNS, has dropped markedly. Some studies suggest that neurological involvement of infected patient occur with different frequency, depending on HIV subtype involved in the infection. Subtype C may have reduced neuroinvasive capacity, possibly due to its different primary conformation of HIV transactivating regulatory protein (Tat), involved in monocyte chemotaxis. This review focus on physiopathologic aspects of HIV infection in CNS and its correlation with HIV clades. |
| first_indexed | 2024-12-22T17:12:52Z |
| format | Article |
| id | doaj.art-908ad9592e6f4b2faa71c287083aa25a |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-22T17:12:52Z |
| publishDate | 2011-12-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-908ad9592e6f4b2faa71c287083aa25a2022-12-21T18:19:02ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272011-12-0169696497210.1590/S0004-282X2011000700023S0004-282X2011000700023Genotypical diversity of HIV clades and central nervous system impairmentIndianara Rotta0Sérgio Monteiro de Almeida1Universidade Federal do ParanáUniversidade Federal do ParanáThe central nervous system (CNS) and the immune system are considered major target organs for HIV infection. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV associated dementia, vacuolar myelopathy and involvement of the peripheral nervous system. Changes in diagnosis and clinical management have changed the aspect of HIV infection so that it is no longer a fatal disease, and has become a chronic disease requiring sustained medical management. After HAART the incidence of most opportunistic infections, including those affecting the CNS, has dropped markedly. Some studies suggest that neurological involvement of infected patient occur with different frequency, depending on HIV subtype involved in the infection. Subtype C may have reduced neuroinvasive capacity, possibly due to its different primary conformation of HIV transactivating regulatory protein (Tat), involved in monocyte chemotaxis. This review focus on physiopathologic aspects of HIV infection in CNS and its correlation with HIV clades.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700023&lng=en&tlng=enHIVAIDSsistema nervoso centralsubtiposgenotipagemHIV demência |
| spellingShingle | Indianara Rotta Sérgio Monteiro de Almeida Genotypical diversity of HIV clades and central nervous system impairment Arquivos de Neuro-Psiquiatria HIV AIDS sistema nervoso central subtipos genotipagem HIV demência |
| title | Genotypical diversity of HIV clades and central nervous system impairment |
| title_full | Genotypical diversity of HIV clades and central nervous system impairment |
| title_fullStr | Genotypical diversity of HIV clades and central nervous system impairment |
| title_full_unstemmed | Genotypical diversity of HIV clades and central nervous system impairment |
| title_short | Genotypical diversity of HIV clades and central nervous system impairment |
| title_sort | genotypical diversity of hiv clades and central nervous system impairment |
| topic | HIV AIDS sistema nervoso central subtipos genotipagem HIV demência |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700023&lng=en&tlng=en |
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