Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases
Masahito Hitosugi,1,2 Katsuo Hamada,2 Kazutaka Misaka2 1Department of Legal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan; 2Department of Internal Medicine, Nagareyama Central Hospital, Nagareyama, Chiba, Japan Abstract: The fermented soybean product natto is a popular tradition...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-01-01
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| Series: | International Journal of General Medicine |
| Online Access: | http://www.dovepress.com/effects-of-bacillus-subtilis-var-natto-products-on-symptoms-caused-by--peer-reviewed-article-IJGM |
| _version_ | 1811287697118986240 |
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| author | Hitosugi M Hamada K Misaka K |
| author_facet | Hitosugi M Hamada K Misaka K |
| author_sort | Hitosugi M |
| collection | DOAJ |
| description | Masahito Hitosugi,1,2 Katsuo Hamada,2 Kazutaka Misaka2 1Department of Legal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan; 2Department of Internal Medicine, Nagareyama Central Hospital, Nagareyama, Chiba, Japan Abstract: The fermented soybean product natto is a popular traditional food in Japan and is considered a health supplement. NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and blood pressure-lowering effects. We examined whether daily intake of NKCP® effectively improves subjective symptoms in patients with lifestyle diseases in this cross-over, double-blind study. Fermented soya extract with subtilisin NAT (nattokinase) as the main component was used as an active placebo. A 4-week course of NKCP® significantly decreased the visual analog scale (VAS) score for shoulder stiffness from 42.3 to 32.4 (P=0.009), the VAS score for low back pain from 25.5 to 18.8 (P=0.02), and the VAS score for coldness of the extremities from 33.1 to 25.7 (P=0.002). However, no significant difference was found in the VAS score for headache. After a 4-week course of active placebo, no significant changes in the VAS score were found for any symptoms. The significant improvement in the symptoms secondary to blood flow disturbance was caused by the improvement in blood flow by NKCP®. The use of dietary supplements based on the Japanese traditional food natto helps to relieve subjective symptoms for patients with lifestyle diseases receiving medical care. Keywords: bacillopeptidase F, Japanese traditional food, lifestyle disease, subjective symptom, supplement |
| first_indexed | 2024-04-13T03:22:52Z |
| format | Article |
| id | doaj.art-908b5f5d9080431dbb52fb289a084da7 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T03:22:52Z |
| publishDate | 2015-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-908b5f5d9080431dbb52fb289a084da72022-12-22T03:04:44ZengDove Medical PressInternational Journal of General Medicine1178-70742015-01-012015default414620063Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseasesHitosugi MHamada KMisaka KMasahito Hitosugi,1,2 Katsuo Hamada,2 Kazutaka Misaka2 1Department of Legal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan; 2Department of Internal Medicine, Nagareyama Central Hospital, Nagareyama, Chiba, Japan Abstract: The fermented soybean product natto is a popular traditional food in Japan and is considered a health supplement. NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and blood pressure-lowering effects. We examined whether daily intake of NKCP® effectively improves subjective symptoms in patients with lifestyle diseases in this cross-over, double-blind study. Fermented soya extract with subtilisin NAT (nattokinase) as the main component was used as an active placebo. A 4-week course of NKCP® significantly decreased the visual analog scale (VAS) score for shoulder stiffness from 42.3 to 32.4 (P=0.009), the VAS score for low back pain from 25.5 to 18.8 (P=0.02), and the VAS score for coldness of the extremities from 33.1 to 25.7 (P=0.002). However, no significant difference was found in the VAS score for headache. After a 4-week course of active placebo, no significant changes in the VAS score were found for any symptoms. The significant improvement in the symptoms secondary to blood flow disturbance was caused by the improvement in blood flow by NKCP®. The use of dietary supplements based on the Japanese traditional food natto helps to relieve subjective symptoms for patients with lifestyle diseases receiving medical care. Keywords: bacillopeptidase F, Japanese traditional food, lifestyle disease, subjective symptom, supplementhttp://www.dovepress.com/effects-of-bacillus-subtilis-var-natto-products-on-symptoms-caused-by--peer-reviewed-article-IJGM |
| spellingShingle | Hitosugi M Hamada K Misaka K Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases International Journal of General Medicine |
| title | Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases |
| title_full | Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases |
| title_fullStr | Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases |
| title_full_unstemmed | Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases |
| title_short | Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases |
| title_sort | effects of bacillus subtilis var natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases |
| url | http://www.dovepress.com/effects-of-bacillus-subtilis-var-natto-products-on-symptoms-caused-by--peer-reviewed-article-IJGM |
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