Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels
Engineering biological processes has become a standard approach to produce various commercially valuable chemicals, therapeutics, and biomaterials. Among these products, bacterial cellulose represents major advances to biomedical and healthcare applications. In comparison to properties of plant cell...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/13/7192 |
| _version_ | 1797528003341713408 |
|---|---|
| author | Gizem Buldum Athanasios Mantalaris |
| author_facet | Gizem Buldum Athanasios Mantalaris |
| author_sort | Gizem Buldum |
| collection | DOAJ |
| description | Engineering biological processes has become a standard approach to produce various commercially valuable chemicals, therapeutics, and biomaterials. Among these products, bacterial cellulose represents major advances to biomedical and healthcare applications. In comparison to properties of plant cellulose, bacterial cellulose (BC) shows distinctive characteristics such as a high purity, high water retention, and biocompatibility. However, low product yield and extensive cultivation times have been the main challenges in the large-scale production of BC. For decades, studies focused on optimization of cellulose production through modification of culturing strategies and conditions. With an increasing demand for BC, researchers are now exploring to improve BC production and functionality at different categories: genetic, bioprocess, and product levels as well as model driven approaches targeting each of these categories. This comprehensive review discusses the progress in BC platforms categorizing the most recent advancements under different research focuses and provides systematic understanding of the progress in BC biosynthesis. The aim of this review is to present the potential of ‘modern genetic engineering tools’ and ‘model-driven approaches’ on improving the yield of BC, altering the properties, and adding new functionality. We also provide insights for the future perspectives and potential approaches to promote BC use in biomedical applications. |
| first_indexed | 2024-03-10T09:51:55Z |
| format | Article |
| id | doaj.art-908b8edac92b4f5ebe834f6dac1ceb48 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:51:55Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-908b8edac92b4f5ebe834f6dac1ceb482023-11-22T02:41:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012213719210.3390/ijms22137192Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product LevelsGizem Buldum0Athanasios Mantalaris1Department of Life Sciences, Imperial College London, London SW7 2AZ, UKWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USAEngineering biological processes has become a standard approach to produce various commercially valuable chemicals, therapeutics, and biomaterials. Among these products, bacterial cellulose represents major advances to biomedical and healthcare applications. In comparison to properties of plant cellulose, bacterial cellulose (BC) shows distinctive characteristics such as a high purity, high water retention, and biocompatibility. However, low product yield and extensive cultivation times have been the main challenges in the large-scale production of BC. For decades, studies focused on optimization of cellulose production through modification of culturing strategies and conditions. With an increasing demand for BC, researchers are now exploring to improve BC production and functionality at different categories: genetic, bioprocess, and product levels as well as model driven approaches targeting each of these categories. This comprehensive review discusses the progress in BC platforms categorizing the most recent advancements under different research focuses and provides systematic understanding of the progress in BC biosynthesis. The aim of this review is to present the potential of ‘modern genetic engineering tools’ and ‘model-driven approaches’ on improving the yield of BC, altering the properties, and adding new functionality. We also provide insights for the future perspectives and potential approaches to promote BC use in biomedical applications.https://www.mdpi.com/1422-0067/22/13/7192bacterial cellulosesynthetic biologybioprocessingsynthetic circuit modeling |
| spellingShingle | Gizem Buldum Athanasios Mantalaris Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels International Journal of Molecular Sciences bacterial cellulose synthetic biology bioprocessing synthetic circuit modeling |
| title | Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels |
| title_full | Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels |
| title_fullStr | Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels |
| title_full_unstemmed | Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels |
| title_short | Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels |
| title_sort | systematic understanding of recent developments in bacterial cellulose biosynthesis at genetic bioprocess and product levels |
| topic | bacterial cellulose synthetic biology bioprocessing synthetic circuit modeling |
| url | https://www.mdpi.com/1422-0067/22/13/7192 |
| work_keys_str_mv | AT gizembuldum systematicunderstandingofrecentdevelopmentsinbacterialcellulosebiosynthesisatgeneticbioprocessandproductlevels AT athanasiosmantalaris systematicunderstandingofrecentdevelopmentsinbacterialcellulosebiosynthesisatgeneticbioprocessandproductlevels |