Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study
Background: Butorphanol was safely used for obstetric analgesia for many years. We attempted to determine if it increases the analgesic effect during patient-controlled epidural labor analgesia (PCEA) and if it affects the labor-process. Methods: Term pregnant women (N = 60) were randomly assigned t...
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IMR Press
2022-03-01
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Series: | Clinical and Experimental Obstetrics & Gynecology |
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Online Access: | https://www.imrpress.com/journal/CEOG/49/3/10.31083/j.ceog4903060 |
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author | Ting Zhou FengYuan Nong MengXia Wang ZhaoJia Liang YaLan Li |
author_facet | Ting Zhou FengYuan Nong MengXia Wang ZhaoJia Liang YaLan Li |
author_sort | Ting Zhou |
collection | DOAJ |
description | Background: Butorphanol was safely used for obstetric analgesia for many years. We attempted to determine if it increases the analgesic effect during patient-controlled epidural labor analgesia (PCEA) and if it affects the labor-process. Methods: Term pregnant women (N = 60) were randomly assigned to two groups, to receive either 1 mg intravenously butorphanol or 10 mL normal saline as placebo at 10 min before intrathecal anesthesia. Pain score, duration of first and second stage of labor, mode of delivery, umbilical artery blood gas, Apgar scores and adverse effects were recorded. Result: Butorphanol shortened the duration of the second stage of labor (t = –2.41, p = 0.019). Women in butorphanol group showed significantly increased incidence of pruritus (x2 = 20.32, p = 0.000), but they also showed significantly increased incidence of the adverse events such as maternal somnolence and dizziness (x2 = 8.366, p = 0.004; x2 = 26.447, p = 0.000 respectively). The pain scores of the two groups showed a linear reduction within 1 h (F = 8.878, p = 0.004), and from intravenous injection of butorphanol to the 5th minute after intrathecal analgesia, the analgesic scores of butorphanol group were significantly lower than those of placebo group (p < 0.05). At the third hour after intrathecal injection, the Visual analogue scale (VAS) score was significantly lower in butorphanol group than placebo group (95% Confidence Interval (CI) –3.02 to –0.28; t = –2.51, p = 0.021). Conclusions: i.v. butorphanol 1 mg alleviates the labor pain during intrathecal puncture, and It will be easier to get the cooperation of pregnant women and shortens the second stage of labor. It effectively relieved the pruritus, but increased the incidence of dizziness and somnolence. |
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issn | 0390-6663 |
language | English |
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publishDate | 2022-03-01 |
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series | Clinical and Experimental Obstetrics & Gynecology |
spelling | doaj.art-908bcc43ed34415bb49d8ee4d0aeb2e92022-12-22T02:11:15ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-03-014936010.31083/j.ceog4903060S0390-6663(22)01712-2Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled studyTing Zhou0FengYuan Nong1MengXia Wang2ZhaoJia Liang3YaLan Li4The Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Jinan University, 510630 Guangzhou, Guangdong, ChinaThe Department of Anesthesiology, Yue Bei People’s Hospital, 512025 Shaoguan, Guangdong, ChinaThe Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Jinan University, 510630 Guangzhou, Guangdong, ChinaThe Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Jinan University, 510630 Guangzhou, Guangdong, ChinaThe Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Jinan University, 510630 Guangzhou, Guangdong, ChinaBackground: Butorphanol was safely used for obstetric analgesia for many years. We attempted to determine if it increases the analgesic effect during patient-controlled epidural labor analgesia (PCEA) and if it affects the labor-process. Methods: Term pregnant women (N = 60) were randomly assigned to two groups, to receive either 1 mg intravenously butorphanol or 10 mL normal saline as placebo at 10 min before intrathecal anesthesia. Pain score, duration of first and second stage of labor, mode of delivery, umbilical artery blood gas, Apgar scores and adverse effects were recorded. Result: Butorphanol shortened the duration of the second stage of labor (t = –2.41, p = 0.019). Women in butorphanol group showed significantly increased incidence of pruritus (x2 = 20.32, p = 0.000), but they also showed significantly increased incidence of the adverse events such as maternal somnolence and dizziness (x2 = 8.366, p = 0.004; x2 = 26.447, p = 0.000 respectively). The pain scores of the two groups showed a linear reduction within 1 h (F = 8.878, p = 0.004), and from intravenous injection of butorphanol to the 5th minute after intrathecal analgesia, the analgesic scores of butorphanol group were significantly lower than those of placebo group (p < 0.05). At the third hour after intrathecal injection, the Visual analogue scale (VAS) score was significantly lower in butorphanol group than placebo group (95% Confidence Interval (CI) –3.02 to –0.28; t = –2.51, p = 0.021). Conclusions: i.v. butorphanol 1 mg alleviates the labor pain during intrathecal puncture, and It will be easier to get the cooperation of pregnant women and shortens the second stage of labor. It effectively relieved the pruritus, but increased the incidence of dizziness and somnolence.https://www.imrpress.com/journal/CEOG/49/3/10.31083/j.ceog4903060butorphanolintrathecal anesthesialabor painpatient controlled epidural analgesiavisual analogue scaleropivacainesufentanyl |
spellingShingle | Ting Zhou FengYuan Nong MengXia Wang ZhaoJia Liang YaLan Li Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study Clinical and Experimental Obstetrics & Gynecology butorphanol intrathecal anesthesia labor pain patient controlled epidural analgesia visual analogue scale ropivacaine sufentanyl |
title | Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study |
title_full | Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study |
title_fullStr | Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study |
title_full_unstemmed | Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study |
title_short | Intravenous butorphanol as an adjunct to patient-controlled epidural analgesia with ropivacaine and sufentanil in labor: a randomized controlled study |
title_sort | intravenous butorphanol as an adjunct to patient controlled epidural analgesia with ropivacaine and sufentanil in labor a randomized controlled study |
topic | butorphanol intrathecal anesthesia labor pain patient controlled epidural analgesia visual analogue scale ropivacaine sufentanyl |
url | https://www.imrpress.com/journal/CEOG/49/3/10.31083/j.ceog4903060 |
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