C-Reactive Protein as a Diagnostic Marker in Dogs: A Review
Acute phase response is a nonspecific reaction to disturbances in homeostasis during which the production of some Acute Phase Proteins (APPs) is stimulated; they are sensitive but nonspecific markers of systemic inflammatory processes. The major positive APP in dogs is the C-reactive protein (CRP)....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/12/20/2888 |
| _version_ | 1797475927661215744 |
|---|---|
| author | Katarzyna Malin Olga Witkowska-Piłaszewicz |
| author_facet | Katarzyna Malin Olga Witkowska-Piłaszewicz |
| author_sort | Katarzyna Malin |
| collection | DOAJ |
| description | Acute phase response is a nonspecific reaction to disturbances in homeostasis during which the production of some Acute Phase Proteins (APPs) is stimulated; they are sensitive but nonspecific markers of systemic inflammatory processes. The major positive APP in dogs is the C-reactive protein (CRP). The dynamic of its concentration changes fast, rising and decreasing rapidly with the onset and removal of the inflammatory stimulus. It increases within the first 4–24 h after the stimulus and reaches up to a 50–100-fold increase of the baseline level. It has been documented that this APP’s concentration is elevated during several diseases, such as pyometra, panniculitis, acute pancreatitis, polyarthritis, sepsis, immune-mediated hemolytic anemia, and neoplasia in dogs. In clinical practice, canine CRP is mostly measured to detect and monitor systemic inflammatory activity and the efficacy of treatments, because it is a more sensitive marker than shifts in leukocyte counts. Blood serum CRP concentration is becoming a part of routine biochemistry panels in many countries. In this article, changes in CRP concentration and its clinical application in healthy and diseased dogs are discussed. |
| first_indexed | 2024-03-09T20:51:43Z |
| format | Article |
| id | doaj.art-908d7822368c4a398189c232ec71cd7b |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T20:51:43Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-908d7822368c4a398189c232ec71cd7b2023-11-23T22:33:38ZengMDPI AGAnimals2076-26152022-10-011220288810.3390/ani12202888C-Reactive Protein as a Diagnostic Marker in Dogs: A ReviewKatarzyna Malin0Olga Witkowska-Piłaszewicz1Department of Large Animals Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, PolandDepartment of Large Animals Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, PolandAcute phase response is a nonspecific reaction to disturbances in homeostasis during which the production of some Acute Phase Proteins (APPs) is stimulated; they are sensitive but nonspecific markers of systemic inflammatory processes. The major positive APP in dogs is the C-reactive protein (CRP). The dynamic of its concentration changes fast, rising and decreasing rapidly with the onset and removal of the inflammatory stimulus. It increases within the first 4–24 h after the stimulus and reaches up to a 50–100-fold increase of the baseline level. It has been documented that this APP’s concentration is elevated during several diseases, such as pyometra, panniculitis, acute pancreatitis, polyarthritis, sepsis, immune-mediated hemolytic anemia, and neoplasia in dogs. In clinical practice, canine CRP is mostly measured to detect and monitor systemic inflammatory activity and the efficacy of treatments, because it is a more sensitive marker than shifts in leukocyte counts. Blood serum CRP concentration is becoming a part of routine biochemistry panels in many countries. In this article, changes in CRP concentration and its clinical application in healthy and diseased dogs are discussed.https://www.mdpi.com/2076-2615/12/20/2888C-reactive proteinCRPmarkerdiagnosticdog |
| spellingShingle | Katarzyna Malin Olga Witkowska-Piłaszewicz C-Reactive Protein as a Diagnostic Marker in Dogs: A Review Animals C-reactive protein CRP marker diagnostic dog |
| title | C-Reactive Protein as a Diagnostic Marker in Dogs: A Review |
| title_full | C-Reactive Protein as a Diagnostic Marker in Dogs: A Review |
| title_fullStr | C-Reactive Protein as a Diagnostic Marker in Dogs: A Review |
| title_full_unstemmed | C-Reactive Protein as a Diagnostic Marker in Dogs: A Review |
| title_short | C-Reactive Protein as a Diagnostic Marker in Dogs: A Review |
| title_sort | c reactive protein as a diagnostic marker in dogs a review |
| topic | C-reactive protein CRP marker diagnostic dog |
| url | https://www.mdpi.com/2076-2615/12/20/2888 |
| work_keys_str_mv | AT katarzynamalin creactiveproteinasadiagnosticmarkerindogsareview AT olgawitkowskapiłaszewicz creactiveproteinasadiagnosticmarkerindogsareview |